- 1. ABI 007
- (UMLS (NCI) C1134696) ABI-007 =Organic Chemical; Pharmacologic Substance
| - 3. ABI2
- [The ABL protein is a constitutively active tyrosine kinase that may regulate signal transduction events in the cytoplasm and processes in the nucleus. It is repressed by SH3 domains and possibly by other regions. ABL-Interactor 2, encoded by the ABI-2 gene, is the substrate for ABL. This protein has an SH3 domain and interacts with the ABL. ABI-2 may function to coordinate the cytoplasmic and nuclear functions of the ABL. It modulates ABL transforming activity and functions as a tumor suppressor in mammalian cells. (From LocusLink, OMIM) ( NCI )] (UMLS (NCI) C0384027) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
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- 2. ABI1
- [This gene plays a role in signal transduction and negative regulation of cell proliferation. ( NCI )] (UMLS (NCI) C1335864) ABl1 Gene;
ABL-Interactor 1 Gene =Gene or Genome ;
◊ [Encoded by human SSH3BP1 Gene, Spectrin SH3 Domain Binding Protein 1 contains similarity to homeotic proteins, several polyproline stretches, and a C terminal SH3 domain required for binding to ABL proteins. Binding SH3 domains of EPS8, SSH3BP1 adaptor protein holds EGFR substrate EPS8 in complex with SOS1, mediating RAS signal transduction to RAC (activation) by regulating RAC-specific GEF activity. Depending on its association with SSH3BP1 or RNTRE, EPS8 participates in EGFR signaling through RAC or in EGFR trafficking through RAB5. EPS8 interacts through its SH3 domain with the EGFR-regulated RAB5 GAP RNTRE, which inhibits EGFR internalization. EPS8 diversion from RAC-activation by RNTRE, results in RAC signaling attenuation. (NCI) ( NCI )] (UMLS (NCI) C1447504) ABL-Interactor Protein 1; E3B1; EPS8 Binding Protein; Interactor Protein ABLBP4; NAP1; NAP1 Binding Protein; Spectrin SH3 Binding Protein; Spectrin SH3 Domain Binding Protein 1; SSH3BP1; Amino Acid, Peptide, or Protein; Biologically Active Substance | - 4. ABI2
- [This gene is involved in the regulation of signal transduction events. ( NCI )] (UMLS (NCI) C1332005) ABI2 Gene;
ABL Interactor 2 Gene;
=Gene or Genome ;
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