- 1. Ad CMV I kappaB alpha
- (UMLS (NCI) C1510775) =Pharmacologic Substance
| - 8. Ad5CMV-p53 Gene/Docetaxel/Doxorubicin
- (UMLS (NCI) C1327753) =Therapeutic or Preventive Procedure ;
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- 2. Ad-CD154
- [An adenovirus vector engineered to produce CD40 ligand. For use as a possible gene therapy agent. May induce apoptosis through the TNF pathway. ( NCI )] (UMLS (NCI) C0796342) Ad-CD40 Ligand;
Ad-CD40L;
Adenovirus 5-CD40 Ligand;
=Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
| - 9. ADCC
- [Antibody-dependent target cell killing by a killer cell. An antibody is directed to the target by antigen-binding arms and anchors to the killer cell by an Fc receptor. Antibody-mediated target cell destruction by non-sensitized effector cells. The identity of the target cell varies, but it must possess surface IgG whose Fc portion is intact. The effector "killer" cell possesses Fc receptors. It may be a lymphocyte lacking conventional B- or T-cell markers, or a monocyte, macrophage, or polynuclear leukocyte, depending on the identity of the target cell. The reaction is complement-independent. ( NCI )] (UMLS (CSP) C0003272) =Cell Function ;
|
- 3. AD-CD40-L/IL-2
- (UMLS (NCI) C0796343) Adenovirus 5-CD40-L Vector/Interleukin-2;
=Therapeutic or Preventive Procedure | - 10. ADCC Assay
- [An assay based on Antibody-Dependent Cellular Cytotoxicity which involves the killing of a target cell by a killer cell by means of an antibody directed to the target by the antigen-binding arms and anchored to the killer cell via an Fc receptor. ( NCI )] (UMLS (NCI) C0201624) =Laboratory Procedure
|
- 4. Ad5CMV
- [A recombinant replication-deficient serotype 5 adenovirus. Containing an expression cassette consisting of the human cytomegalovirus (CMV) promoter and the simian virus 40 (SV40) polyadenylation signal, Ad5CMV is used as a transfer vector for inserting genes of interest into target cells for expression. (NCI04) ( NCI )] (UMLS (NCI) C1510774) =Nucleic Acid, Nucleoside, or Nucleotide ;
| - 11. ADCOMP
- (UMLS (NCI) C0279504) =Therapeutic or Preventive Procedure
|
- 5. Ad5CMV p53 Gene
- [A replication-defective adenoviral-CMV vector that encodes a wild-type p53 gene. Ad5CMV-p53 induces tumor cells that have been transfected with the vector to produce wild-type p53, a tumor suppressor gene that is deleted or mutated in a significant number of cancers. In transfected tumor cells, the wild-type p-53 gene product exerts an antitumor effect by blocking cell cycle progression at the G1/S regulation point, activating DNA repair proteins in the presence of DNA damage, and initiating apoptosis when DNA damage is irreparable. (NCI04) ( NCI )] (UMLS (NCI) C0678021) =Pharmacologic Substance
| - 12. ADCY9
- [This gene is involved in nucleotide metabolism and signal transduction. ( NCI )] (UMLS (NCI) C1332025) ADCY9 Gene;
Adenylate Cyclase 9 Gene;
=Gene or Genome ;
|
- 6. Ad5CMV-p53 gene/Cisplatin/Fluorouracil
- (UMLS (NCI) C1134689) =Therapeutic or Preventive Procedure
| - 13. ADCY9
- [Adenylyl cyclases are membrane-associated enzymes of the lyase class that are expressed in most human tissues. These enzymes catalyze the formation of cyclic AMP and pyrophosphate from ATP and are regulated by a family of G protein-coupled receptors, protein kinases, and calcium. Adenylyl cyclase is encoded by the ADCY9 gene and widely distributed. It is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin. It may play a fundamental role in situations where fine interplay between intracellular Ca(2+) and cAMP determines the cellular function. It also may be a physiologically relevant docking site for calcineurin. ( NCI )] (UMLS (NCI) C1382029) Adenyl Cyclase 9;
Adenylate Cyclase;
Adenylyl Cyclase 9;
Adenylylcyclase 9;
ATP Pyrophosphate-Lyase;
EC 4.6.1.1 =Amino Acid, Peptide, or Protein; Enzyme |
- 7. Ad5CMV-p53 gene/Docetaxel
- (UMLS (NCI) C1134690) =Therapeutic or Preventive Procedure
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