- 1. AH receptor
- [The aryl hydrocarbon receptor (AhR) is a ligand-activated helix/loop/helix transcription factor found in a variety of vertebrate species. Many foreign planar aromatic compounds, such as polycyclic aromatic compounds and halogenated aromatic compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are ligands of AhR. Unlike the steroid/thyroid hormone receptors, there is no known physiological ligand for the AhR. ( NCI )] (UMLS (CSP) C0052441) =Amino Acid, Peptide, or Protein; Receptor
| - 3. AHR
- [This gene is involved in the regulation of xenobiotic-metabolizing enzymes. ( NCI )] (UMLS (NCI) C0596123) =Gene or Genome ;
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- 2. AHR
- [approximately 280kD soluble protein complex; binds and mediates carcinogenesis by polycyclic aromatic hydrocarbons, heterocyclic amines, and chlorinated aromatic compounds. ( CSP )] (UMLS (CSP) C1384603) aromatic hydrocarbon receptor =Amino Acid, Peptide, or Protein; Receptor =Nuclear Receptor;
| - 4. Ahr Signal Transduction Pathway
- [The Ah receptor, bHLH/PAS transcription factor, upon binding of an agonist such as 2,3,7,8-tetrachlorodibenzo-p-dioxin translocates into the nucleus and heterodimerizes with the transcription factor ARNT. The Ahreceptor/ARNT heterodimer binds to dioxin-responsive elements and alters expression of a number of genes including; CYP1A1, CYP1A2, CYP1B1, and NAD(P)H quinone oxidoreductase. The inactive form of the Ah receptor exists in the cytoplasm as a tetrameric complex composed of the ligand binding subunit, a dimer of the 90-kDa heat shock protein, and X-associated protein 2 (also refered to as AIP or ARA9). (BioCarta) ( NCI )] (UMLS (NCI) C1510689) =Molecular Function ;
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