- 1. A Kinase (PRKA) Anchor Protein (Gravin) 12 Gene
- [This gene plays a role in signal transduction and angiogenesis. ( NCI )] (UMLS (NCI) C1332070) AKAP12;
AKAP12 Gene;
=Gene or Genome | - 12. Akiak Native Community
- (UMLS (HL7) C1550797) =Population Group =NativeEntityAlaska;
|
- 2. A Kinase (PRKA) Anchor Protein (Yotiao) 9
- [The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in many isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3. (from LocusLink) ( NCI )] (UMLS (NCI) C0672770) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 13. akinetic epilepsy
- [ ] (UMLS (CSP) C0347869) =Disease or Syndrome
|
- 3. A Kinase (PRKA) Anchor Protein (Yotiao) 9 Gene
- [This gene plays a role in signal transduction and modulates synaptic transmission. ( NCI )] (UMLS (NCI) C1332072) AKAP9;
AKAP9 Gene;
=Gene or Genome | - 14. AKR
- (UMLS (NCI) C0025918) =Mammal
|
- 4. A Kinase (PRKA) Anchor Protein 12
- [The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. (from LocusLink) ( NCI )] (UMLS (NCI) C0289793) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 15. AKR7A2
- [This gene is involved in the detoxification of xenobiotics. ( NCI )] (UMLS (NCI) C1332073) AKR7A2 Gene;
Aldo-Keto Reductase Family 7, Member A2 (Aflatoxin Aldehyde Reductase) Gene;
=Gene or Genome |
- 5. A Kinase (PRKA) Anchor Protein 13 Gene
- [This gene is involved in signal transduction and protein trafficking. ( NCI )] (UMLS (NCI) C1332071) AKAP13;
AKAP13 Gene;
=Gene or Genome | - 16. AKT
- [Expressed in diverse tissues, Protein Kinase B (AKT/RAC Family) is a group (Alpha, Beta and Gamma) of cytoplasmic serine/threonine enzymes that covalently transfer the terminal, gamma phosphate group from ATP to a variety of substrate proteins and regulate cell signaling responses to insulin, PDGF, and IGF1 (through PI3K) involved in cell survival, cell proliferation, differentiation, apoptosis, glycogen synthesis, and glucose uptake. ( NCI )] (UMLS (NCI) C0164786) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 6. A Kinase Anchor Protein 13
- [Encoded by human oncogene AKAP13 Gene, 424-amino acid 49 kD A Kinase Anchor Protein 13 is a signal transduction RHO/RAC GEF involved in cytoskeletal organization and cell cycle progression. Alpha helical hydrophilic LBC is conserved among vertebrates and expressed in skeletal muscle, heart, lung, and hematopoietic cells. It contains phosphorylation sites, N-terminal DH and PH domains, and an N-terminal EF-hand motif. LBC binds to PKA RII tethering it near substrates. AKAP13 stimulates RHO/RAC, but not CDC42 or RAS. In ovary, placenta, breast, and testis, 170 kD BRX contains a LBC region preceded by 3 novel regions; C-terminal regions 4 and 5 bind to the ESR1 ligand-binding domain. BRX also binds RXR, PPAR, and THR. Chimeric onco-LBC lacks the C-terminus, which promotes transforming activity. Proto-LBC is membrane bound; onco-LBC is cytosolic. (OMIM, Swiss-Prot, and NCI) ( NCI )] (UMLS (NCI) C1318045) AKAP13;
A-Kinase (PRKA) Anchor Protein 13;
BRX;
HT31;
LBC;
P47 =Amino Acid, Peptide, or Protein; Biologically Active Substance | - 17. AKT1
- [RAC-Alpha Serine/Threonine Kinase (AKT1) encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. The activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. AKT1 also promotes cell survival and regulates nitric oxide from endothelium, target of the PDGF-activated phosphatidylinositol 3-kinase. (From LocusLink and NCI) ( NCI )] (UMLS (NCI) C0285558) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 7. A kinase anchoring protein
- [class of proteins that target cAMP dependent protein kinase to various sites within the cell. ( CSP )] (UMLS (CSP) C0872014) AKAP;
=Amino Acid, Peptide, or Protein; Biologically Active Substance =binding protein;
| - 18. AKT1
- [This gene is involved in signal transduction and negative regulation of apoptosis. It also plays a role in glucose transport, glycogen synthesis, protein synthesis and neuronal survival. ( NCI )] (UMLS (NCI) C0812228) AKT1 Gene;
v-akt Murine Thymoma Viral Oncogene Homolog 1 Gene =Gene or Genome |
- 8. AK
- [constituent state of the United States of America; it lies at the extreme northwest of the North American continent and is the largest peninsula in the Western Hemisphere. ( CSP )] (UMLS (NCI) C0001905) =Geographic Area ;
| - 19. AKT2
- [The AKT2 oncogene encodes RAC-beta protein kinase, belonging to a serine/threonine kinase subfamily containing SH2-like domains. The AKT2 isoform of PI-dependent protein kinase Akt is enriched in insulin-responsive tissues and may function in the metabolic actions of that hormone. Glucose homeostasis depends on insulin responsiveness in target tissues. Insulin induces phosphorylation of scaffolding proteins and activation of PI3-kinase, which activate Akt. A deficiency of Akt2 impairs the ability of insulin to lower blood glucose and may function in the maintenance of normal glucose homeostasis. (from OMIM 164731 and NCI) ( NCI )] (UMLS (NCI) C0166559) =Amino Acid, Peptide, or Protein; Enzyme
|
- 9. Ak Chin Indian Community of the Maricopa (Ak Chin)
- (UMLS (HL7) C1554221) =Population Group =NativeEntityContiguous;
| - 20. AKT2
- [This gene plays a role in glucose homeostasis and the inhibition of apoptosis. ( NCI )] (UMLS (NCI) C0812230) AKT2 Gene;
v-akt MurineThymoma Viral Oncogene Homolog 2 Gene =Gene or Genome |
- 10. Ak-Pred
- (UMLS (NCI) C0305116) =Steroid; Pharmacologic Substance ;
| - 21. AKT3
- [Highly expressed in brain, lung, kidney and fetal heart, liver, brain by human AKT3 Gene (AKT/RAC Family) as alternative isoforms 1 (479-aa, 55.8-kD) and 2 (465-aa; shorter C-terminus), cytoplasmic Protein Kinase B Gamma contains a PH domain that binds PI(3)K alpha and promotes plasma membrane translocation after cell stimulation. Fully active when phosphorylated on threonine and serine residues, AKT3 phosphorylates several proteins to regulate cell signaling responses to insulin, PDGF, and IGF1 involved in cell proliferation, differentiation, apoptosis, glycogen synthesis, and glucose uptake. (NCI) ( NCI )] (UMLS (NCI) C0673232) =Amino Acid, Peptide, or Protein; Enzyme
|
- 11. Akiachak Native Community
- (UMLS (HL7) C1550796) =Population Group =NativeEntityAlaska;
| - 22. AKT3
- [This gene is involved in signal transduction and the inhibition of apoptosis. ( NCI )] (UMLS (NCI) C1332074) AKT3 Gene;
v-akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma) Gene;
=Gene or Genome |
home
