- 1. 7a-[9-[(4,4,5,5,5,-Pentafluoropentyl)sulphinyl]nonyl]-estra-1,3,5(10)-triene-3,17b-diol
- [A synthetic estrogen receptor antagonist. Unlike tamoxifen (which has partial agonist effects) and the aromatase inhibitors (which reduce the estrogen available to tumor cells), fulvestrant binds competitively to estrogen receptors in breast cancer cells, resulting in estrogen receptor deformation and decreased estrogen binding. In vitro studies indicate that fulvestrant reversibly inhibits the growth of tamoxifen-resistant, estrogen-sensitive, human breast cancer cell lines. (NCI04) ( NCI )] (UMLS (NCI) C0935916) FULVESTRANT;
FULVESTRANT PREPARATION =Steroid; Pharmacologic Substance ;
=[AN500] ANTINEOPLASTIC HORMONES;
Unclassified Ingredients =FULVESTRANT 50 MG/ML;
| - 7. Apex of the Heart
- (UMLS (NCI) C0225811) =Body Location or Region
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- 2. AP Endonuclease Class I
- [APEX Nuclease, encoded by the APE1 gene, is a ubiquitous monomeric apurinic/apyrimidinic DNA repair endonuclease (AP/EXOA family) with 3-prime-, 5-prime-exonuclease, DNA 3-prime repair diesterase, and DNA 3-prime-phosphatase activities. The constitutive gene contains five exons spanning 2.64 kb; the first exon is untranslated. The 0.5 kb upstream DNA contains only a possible CCAAT box and no other regulatory sites or a TATA box. A potent activator of p53 protein, APE1 may protect against cell lethality and suppress mutations produced by spontaneous hydrolysis, by chemicals and radiation, or by DNA glycosylases that remove abnormal bases from DNA. Abasic sites that can block DNA replication and cause mutations must be corrected to restore genetic integrity. A repressor of the PTH gene, APE binds to promoter negative Ca(2+)-response elements, which are also present in the APE1 gene. ( NCI )] (UMLS (NCI) C0140145) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 8. Apex of the Lung
- (UMLS (NCI) C0225703) =Body Location or Region
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- 3. APEH
- [This gene plays a role in the degradation of oxidatively-damaged proteins in living cells. ( NCI )] (UMLS (NCI) C1332101) APEH Gene;
N-Acylaminoacyl-Peptide Hydrolase Gene =Gene or Genome ;
| - 9. Apex of the Prostate
- [THe uppermost part of the prostate gland. ( NCI )] (UMLS (NCI) C0227959) =Body Part, Organ, or Organ Component
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- 4. APEX Nuclease (Apurinic/Apyrimidinic Endonuclease) 2 Gene
- [This gene plays a role in DNA recognition and repair. ( NCI )] (UMLS (NCI) C1425157) APEX2;
APEX2 Gene =Gene or Genome | - 10. Apex of the Tongue
- (UMLS (NCI) C0226946) =Body Location or Region
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- 5. APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 Gene
- [This gene is involved in DNA repair processes. ( NCI )] (UMLS (NCI) C1332102) APEX1;
APEX1 Gene =Gene or Genome ;
| - 11. APEXCARDIOGRAM
- [ ] (UMLS (ICD9CM) C0199612) =Diagnostic Procedure
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- 6. APEX Nuclease-Like 2
- [Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. Apurinic/Apyrimidinic Endonuclease 2, a protein encoded by the APEXL2 gene, has a weak class II AP endonuclease activity. Most of this protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair (BER). (From LocusLink 27301) ( NCI )] (UMLS (NCI) C1332330) APEXL2;
Apurinic/Apyrimidinic Endonuclease 2;
Apurinic/Apyrimidinic Endonuclease-Like 2 =Amino Acid, Peptide, or Protein; Enzyme | |
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