UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
B B B0 B1 B4 B7 B8 BA BB BC BD BE BF BG BH BI BK BL BM BN BO BP BR BS BT BU BV BW BX BY BZ
BE BE+ BEA BEB BEC BED BEE BEF BEG BEH BEI BEK BEL BEM BEN BEP BER BES BET BEU BEV BEX
selected terms: 884 page 1 of 9

1. (+)-1-Beta-D-arabinofuranosyl-5-[(E)-2-bromovi- ny1] uracil
[A synthetic thymidine analogue with potent antiviral activity against herpes simplex and varicella zoster viruses. Sorivudine is phosphorylated into triphosphate form within the cells and this metabolite interferes with viral DNA replication by inhibiting DNA polymerase activity without been incorporated into elongating viral DNA. Due to the dangerous effects of drug-drug interactions via its metabolite, sorivudine has been removed from the market. ( NCI )] (UMLS (NCI) C0207628) =Organic Chemical; Pharmacologic Substance ;
51. 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-(2-(di-methylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-(2S-cis)-,(S)-hydoxybutanedioate(1:1)
[A benzothiazepine derivative and a calcium channel blocker with vasodilator, antihypertensive and cardiovascular properties. Diltiazem maleate inhibits the influx of calcium ions of coronary and peripheral vascular smooth muscle. This leads to a dilation of peripheral and coronary blood vessels, and results in a reduction of myocardial oxygen requirement and in an increase in myocardial oxygen delivery. In addition, diltiazem maleate has a potent negative chronotropic effect with only a mild negative inotropic effect. This drug is used as an antiarrhythmic and an antianginal agent. ( NCI )] (UMLS (NCI) C0282138) =Organic Chemical; Pharmacologic Substance ;
2. (11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione
[main glucocorticoid secreted by the adrenal cortex; its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. ( CSP )] (UMLS (NCI) C0020268) =Steroid; Pharmacologic Substance; Hormone =[HS051] GLUCOCORTICOIDS;
Pregnenediones;
[DE200] ANTI-INFLAMMATORY, TOPICAL;
[RS100] ANTI-INFLAMMATORIES, RECTAL;
[RS202] HEMORRHOIDAL PREPARATIONS WITH STEROID;
=hydrocortisone 17-butyrate 21-propionate;
HYDROCORTISONE ACETATE;
11beta,17,21-Trihydroxypregn-4-ene-3,20-dione 17-Valerate;
11-beta,17-alpha,21-Trihydroxy-4-pregnene-3,20-dione 17-alpha-butyrate;
Hydrocortisone Cypionate;
Hydrocortisone Sodium Phosphate;
(11beta)-21-(3-Carboxy-1-oxopropyl)-11,17-dihydroxypregn-4-ene-3,20-dione, Monosodium Salt;
HYDROCORTISONE ACETONIDE;
hydrocortisone 17-butyrate 21-propionate;
HYDROCORTISONE ACETATE;
11beta,17,21-Trihydroxypregn-4-ene-3,20-dione 17-Valerate;
11-beta,17-alpha,21-Trihydroxy-4-pregnene-3,20-dione 17-alpha-butyrate;
Hydrocortisone Cypionate;
Hydrocortisone Sodium Phosphate;
(11beta)-21-(3-Carboxy-1-oxopropyl)-11,17-dihydroxypregn-4-ene-3,20-dione, Monosodium Salt;
HYDROCORTISONE POWDER (GM);
HYDROCORTISONE,NONSTERILE PWDR;
HYDROCORTISONE 10 MG;
HYDROCORTISONE 20 MG;
HYDROCORTISONE 25 MG;
HYDROCORTISONE ACETONIDE;
HYDROCORTISONE 5 MG;
Hydrocortisone 1.67 MG/ML;
HYDROCORTISONE 2.5 %;
HYDROCORTISONE 2 %;
HYDROCORTISONE 0.1 %;
HYDROCORTISONE 1 %;
HYDROCORTISONE 1 %WW;
HYDROCORTISONE 0.25 %;
HYDROCORTISONE 100 %;
HYDROCORTISONE 0.5 %
52. 1-(2-(beta-naphthyloxy)ethyl)-3-methyl-2-pyrazolin-5-one
[A pyrazolinone derivative with potential antimetastatic activities. Nafazatrom, originally developed as an antithrombotic agent, inhibits the key prostaglandin catabolic enzyme, 15-hydroxyprostaglandin dehydrogenase, thereby prolonging the biological half-life of prostacyclin (prostaglandin I2; PGI2) and preventing intravascular coagulation. This agent also serves as a reducing cofactor with the hydroperoxidase moiety of cyclooxygenase and accelerates the conversion of arachidonic acid into precursors of PGI2. Elevated level of PGI2 prevents aggregation of platelets and subsequently, decreases the formation of tumor cell-platelet aggregates as well as their sequestration in blood vessels, which is an important initiating step in the development of metastasis. ( NCI )] (UMLS (NCI) C0053025) =Organic Chemical; Pharmacologic Substance
3. (11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
[synthetic glucocorticoid with the general properties of the corticosteroids. ( CSP )] (UMLS (NCI) C0032950) =Steroid; Pharmacologic Substance ;
=[HS051] GLUCOCORTICOIDS;
Pregnadienetriols;
corticosteroid analog;
=(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione;
Prednicarbate;
PREDNISOLONE ACETATE;
Prednisolone Tebutate;
PREDNISOLONE SODIUM PHOSPHATE;
PREDNISOLONE ACETATE;
Prednisolone Tebutate;
PREDNISOLONE SODIUM PHOSPHATE;
PREDNISOLONE POWDER (GM);
PREDNISOLONE 5 MG;
PREDNISOLONE 15 MG/5ML
53. 1-.beta.-D-Ribofuranosyl-1H-1,2, 4-triazole-3-carboxamide
[1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamid e; antiretroviral agent with potential efficacy against AIDS. ( CSP )] (UMLS (NCI) C0035525) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
=[AM800] ANTIVIRALS;
ribonucleoside;
Reverse Transcriptase Inhibitor;
nucleoside analog =RIBAVIRIN 200 MG;
RIBAVIRIN 42 X 200 MG;
RIBAVIRIN 70 X 200 MG;
RIBAVIRIN 84 X 200 MG;
RIBAVIRIN 6;
4. (11beta)-11,21-Dihydroxypregn-4-ene-3,20-dione
[adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. ( CSP )] (UMLS (NCI) C0010124) =Steroid; Pharmacologic Substance; Hormone =[HS051] GLUCOCORTICOIDS;
54. 1-beta-D-Ribofuranosyl-2(1H)-pyrimidinone
[A synthetic cytidine analogue and a cytidine deaminase inhibitor with anticancer activity. Following metabolic activation by phosphorylation and incorporation into DNA, zebularine inhibits DNA methyltransferase through covalent complex formation between the enzyme and zebularine-substituted DNA, hence resulting in non-specific, genome-wide induction of demethylation including the removal of aberrant methylation of promoter regions of genes critical for normal cellular functions. ( NCI )] (UMLS (NCI) C0084253) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
5. (11beta)-21-(3-Carboxy-1-oxopropyl)-11,17-dihydroxypregn-4-ene-3,20-dione, Monosodium Salt
[The sodium salt of hydrocortisone succinate with glucocorticoid property. Hydrocortisone sodium succinate is chemically similar to the endogenous hormone that stimulates anti-inflammatory and immunosuppressive activities, in addition to exhibit minor mineralocorticoid effects. This agent binds to intracellular glucocorticoid receptors and is translocated into the nucleus, where it initiates the transcription of glucocorticoid-responsive genes such as various cytokines and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both potent mediators of inflammation. ( NCI )] (UMLS (NCI) C0770560) Cortisol Sodium Succinate;
Hydrocortisone 21-Sodium Succinate;
Hydrocortisone Na Succinate;
Hydrocortisone Sodium Succinate;
HYDROCORTISONE SODIUM SUCCINATE PREPARATION;
Sodium hydrocortisone succinate =Steroid; Pharmacologic Substance ;
=(11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione;
=HYDROCORTISONE SODIUM SUCCINATE 125 MG/ML;
HYDROCORTISONE SODIUM SUCCINATE 250 MG;
HYDROCORTISONE SODIUM SUCCINATE 50 MG/ML;
HYDROCORTISONE SODIUM SUCCINATE 500 MG;
HYDROCORTISONE SODIUM SUCCINATE 100 MG;
HYDROCORTISONE SODIUM SUCCINATE 1000 MG
55. 10,11-Benzofluoranthene
[A yellowish, aromatic hydrocarbon consisting of five fused rings and formed by the incomplete combustion of organic matter. Benzo(j)fluoranthene is primarily found in certain foods, cigarette smoke, gasoline exhaust, coal tar, coal smoke, oil heat emissions, crude oils and used motor oils. This substance is used only for research purposes. Benzo(j)fluoranthene is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0053206) =Organic Chemical; Pharmacologic Substance; Hazardous or Poisonous Substance
6. (11beta,16alpha)-21-(3,3-Dimethyl-1-oxobutoxy)-9-fluoro-11-hydroxy-16,17-((1-methylethylidene)bis(oxy))pregna-1,4-diene-3,20-dione
[The hexacetonide salt form of triamcinolone, a synthetic glucocorticosteroid with immunosuppressive and anti-inflammatory activity. Triamcinolone hexacetonide binds to specific cytosolic glucocorticoid receptors and subsequently interacts with glucocorticoid receptor response element on DNA and alters gene expression. This results in an induction of the synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. Consequently, an overall reduction in chronic inflammation and autoimmune reactions are accomplished. ( NCI )] (UMLS (NCI) C0077004) =Steroid; Pharmacologic Substance ;
=(11beta,16alpha)-9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione;
9-alpha-Fluoro-11-beta,21-dihydroxy-16-alpha-isopropylidenedioxy-1,4-pregnadiene,3,20-dione =TRIAMCINOLONE HEXACETONIDE 5 MG/ML;
TRIAMCINOLONE HEXACETONIDE 20 MG/ML;
56. 11,12-Benzo[k]fluoranthene
[A pale yellow aromatic hydrocarbon consisting of five fused rings and is produced by the incomplete combustion of organic matter. Benzo(k)fluoranthene is primarily found in gasoline exhaust, cigarette smoke, coal tar, coal and oil combustion emissions, lubricating oils, used motor oils and crude oils. This substance is used only for research purposes. Benzo(k)fluoranthene is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0053207) =Organic Chemical; Hazardous or Poisonous Substance ;
7. (11beta,16alpha)-9,21-Dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione
[The furoate salt form of mometasone, a synthetic topical glucocorticosteroid receptor agonist with anti-inflammatory, anti-pruritic and vasoconstrictive properties. Mometasone furoate exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. This results in synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators.. Specifically, mometasone furoate appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from phospholipid membrane by phospholipase A2. ( NCI )] (UMLS (NCI) C0066700) =Steroid; Pharmacologic Substance =Pregnadienediols;
MOMETASONE =MOMETASONE FUROATE 0.1 %
57. 11-beta,17-alpha,21-Trihydroxy-4-pregnene-3,20-dione 17-alpha-butyrate
[The butyrate salt form of hydrocortisone, a synthetic glucocorticoid receptor agonist with antiinflammatory, antipruritic and vasoconstrictive effects. Binding and activation of the glucocorticoid receptor results in the activation of lipocortin that in turn inhibits cytosolic phospholipase A2. Lack of phospholipase A2 prevents the release of arachidonic acid, precursor for inflammatory mediator prostaglandins and leukotrienes, from the cell membrane. Secondly, mitogen-activated protein kinase (MAPK) phosphatase 1 is induced, thereby leading to dephosphorylation and inactivation of Jun N-terminal kinase directly inhibiting c-Jun mediated transcription. Finally, transcriptional activity of nuclear factor (NF)-kappa-B is blocked, thereby inhibits the transcription of cyclooxygenase 2, which is essential for prostaglandin production. ( NCI )] (UMLS (NCI) C0352536) =Steroid; Pharmacologic Substance =(11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione;
=HYDROCORTISONE BUTYRATE 0.1 %
8. (11beta,16alpha)-9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
[synthetic glucocorticoid used in replacement therapy for adrenal insufficiency and as an anti-inflammatory and immunosuppressant in a variety of disorders. ( CSP )] (UMLS (NCI) C0040864) =Steroid; Pharmacologic Substance ;
=[HS051] GLUCOCORTICOIDS;
Pregnadienes;
Steroids, Fluorinated;
corticosteroid analog =9-alpha-Fluoro-11-beta,21-dihydroxy-16-alpha-isopropylidenedioxy-1,4-pregnadiene,3,20-dione;
TRIAMCINOLONE DIACETATE;
1,4-Pregnadiene-2,20-dione-16,17-cyclopentylidenedioxy-9-fluoro-11,21-dihydroxy-21-acetate;
9-alpha-Fluoro-11-beta,21-dihydroxy-16-alpha-isopropylidenedioxy-1,4-pregnadiene,3,20-dione;
TRIAMCINOLONE DIACETATE;
(11beta,16alpha)-21-(3,3-Dimethyl-1-oxobutoxy)-9-fluoro-11-hydroxy-16,17-((1-methylethylidene)bis(oxy))pregna-1,4-diene-3,20-dione;
TRIAMCINOLONE 2 MG;
TRIAMCINOLONE 8 MG;
TRIAMCINOLONE 40 MG/ML;
TRIAMCINOLONE 4 MG;
TRIAMCINOLONE 1 MG
58. 11-beta-Hydroxy-6-alpha-methylpregn-4-ene-3,20-dione
[A topical, synthetic glucocorticoid with metabolic, anti-inflammatory and anti-allergic properties. Medrysone exerts its effect by interacting with specific intracellular glucocorticoid receptors and subsequently binds to DNA to modify gene expression. This results in an induction of the synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. Consequently, an overall reduction in chronic inflammation and autoimmune reactions is accomplished. ( NCI )] (UMLS (NCI) C0065865) =Steroid; Pharmacologic Substance ;
=Pregnenediones;
[OP300] ANTI-INFLAMMATORIES, TOPICAL OPHTHALMIC =MEDRYSONE 1 %;
9. (11Beta,16alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
[anti-inflammatory 9-fluoro-glucocorticoid. ( CSP )] (UMLS (NCI) C0011777) =Steroid; Pharmacologic Substance ;
=[HS051] GLUCOCORTICOIDS;
Pregnadienetriols;
Steroids, Fluorinated;
corticosteroid analog;
[DE200] ANTI-INFLAMMATORY, TOPICAL;
[OP300] ANTI-INFLAMMATORIES, TOPICAL OPHTHALMIC =9-Fluoro-11-beta,21-dihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione;
Dexamethasone acetate;
DEXAMETHASONE SODIUM PHOSPHATE;
Dexamethasone acetate;
DEXAMETHASONE SODIUM PHOSPHATE;
Dexamethasone 0.1 MG/ML;
DEXAMETHASONE 0.25 MG;
DEXAMETHASONE 0.5 MG;
DEXAMETHASONE 1 MG;
DEXAMETHASONE 1.5 MG;
DEXAMETHASONE 4 MG;
DEXAMETHASONE 6 MG;
DEXAMETHASONE 2 MG;
DEXAMETHASONE 0.5 MG/0.5ML;
DEXAMETHASONE 0.75 MG;
DEXAMETHASONE SODIUMPHOSPHATE;
DEXAMETHASONE 0.1 %;
DEXAMETHASONE 0.04 %;
DEXAMETHASONE 0.012 %
59. 11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-Acetate
[The acetate salt of a synthetic glucocorticoid receptor agonist with immunosuppressive and antiinflammatory effects. Methylprednisolone acetate is converted into active prednisolone in the body, which activates glucocorticoid receptor mediated gene expression. This includes inducing synthesis of anti-inflammatory protein IkappaB-alpha and inhibiting synthesis of nuclear factor kappaB (NF-kappaB). As a result, proinflammatory cytokine production such as IL-1, IL-2 and IL-6 is down-regulated and cytotoxic T-lymphocyte activation is inhibited. Therefore, an overall reduction in chronic inflammation and autoimmune reactions may be achieved. ( NCI )] (UMLS (NCI) C0600901) =Steroid; Pharmacologic Substance ;
=(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione;
[DE200] ANTI-INFLAMMATORY, TOPICAL;
[RS100] ANTI-INFLAMMATORIES, RECTAL;
Unclassified Ingredients =METHYLPREDNISOLONE ACETATE 40 MG/ML;
METHYLPREDNISOLONE ACETATE 0.25 %;
METHYLPREDNISOLONE ACETATE 1 %;
METHYLPREDNISOLONE ACETATE 10 MG;
METHYLPREDNISOLONE ACETATE 20 MG/ML;
METHYLPREDNISOLONE ACETATE 80 MG/ML;
METHYLPREDNISOLONEACETATE 0.25 %
10. (11beta,16alpha,17beta)-11-Hydroxy-16,17-dimethyl-17-(1-oxopropyl)androsta-1,4-dien-3-one
[A derivative of prednisolone, a synthetic glucocorticoid with anti-inflammatory and immunosuppressive property. Upon binding to the cytosolic glucocorticoid receptor and cell entry, rimexolone activates specific glucocorticoid response elements, resulting in altered gene expression. These include induction of synthesis of anti-inflammatory protein IkappaB-alpha and inhibition of synthesis of nuclear factor kappaB (NFkappa B). As a result, pro-inflammatory cytokine production such as interleukin-1 (IL-1), IL-2 and IL-6 is down-regulated and cytotoxic T-lymphocyte activation inhibited. Therefore, an overall reduction in chronic inflammation and autoimmune reactions may be achieved. ( NCI )] (UMLS (NCI) C0140594) =Steroid; Pharmacologic Substance ;
=Pregnadienes;
[OP300] ANTI-INFLAMMATORIES, TOPICAL OPHTHALMIC;
Unclassified Ingredient Preparations;
=RIMEXOLONE 1 %
60. 11beta,17,21-Trihydroxypregn-4-ene-3,20-dione 17-Valerate
[The valerate salt form of hydrocortisone, a synthetic glucocorticoid receptor agonist with antiinflammatory, antipruritic and vasoconstrictive effects. Binding and activation of the glucocorticoid receptor results in the activation of lipocortin that in turn inhibits cytosolic phospholipase A2. Lack of phospholipase A2 prevents the release of arachidonic acid, precursor for inflammatory mediator prostaglandins and leukotrienes, from the cell membrane. Secondly, mitogen-activated protein kinase (MAPK) phosphatase 1 is induced, thereby leads to dephosphorylation and inactivation of Jun N-terminal kinase directly inhibiting c-Jun mediated transcription. Finally, transcriptional activity of nuclear factor (NF)-kappa-B is blocked, thereby inhibits the transcription of cyclooxygenase 2, which is essential for prostaglandin production. ( NCI )] (UMLS (NCI) C0063079) =Steroid; Pharmacologic Substance ;
=(11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione;
=HYDROCORTISONE VALERATE 0.2 %
11. (11beta,16beta)-9-Chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione
[A drug being studied in the treatment of graft-versus-host disease. It belongs to a family of drugs called corticosteroids. ( NCI )] (UMLS (NCI) C0004905) =Steroid; Pharmacologic Substance; Hormone
61. 17 Beta-hydroxy-2 alpha-methyl-5 alpha-androstan-3-one
(UMLS (NCI) C0960041) 2 Alpha-5 alpha-17 beta-17-hydroxy-2-methyl-androstan-3-one;
2 Alpha-methylandrostan-17 beta-ol-3-one;
2 Alpha-methyldihydrotestosterone;
2.alpha.-Methyldihydrotestosterone;
5.alpha.-Androstan-3-one, 17.beta.-hydroxy-2.alpha.-methyl- =Steroid; Pharmacologic Substance
12. (11beta,16beta)-9-Chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione Dipropionate
[The dipropionate salt of a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, beclomethasone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. ( NCI )] (UMLS (NCI) C0004906) =Steroid; Pharmacologic Substance ;
62. 17 Beta-Hydroxysteroid Dehydrogenase Type 7
[Encoded by human HSD17B7 Gene (SDR Family) and expressed in breast, ovaries, pregnant uterus, placenta, testis, thymus, prostate, fetal liver, and some neural tissues, 341-amino acid 38-kD 17-Beta-Hydroxysteroid Dehydrogenase 7 oxidizes or reduces estrogens and androgens. Responsible for biosynthesis of estradiol in the corpus luteum during pregnancy, the membrane-associated phosphorylated enzyme is nearly 75% identical to rodent proteins and contains a short chain dehydrogenase domain. Close to the transmembrane domain, HSD17B7 contains a 28-residue superficial loop: a candidate prolactin receptor (PRLR)-binding domain. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C1334066) 17 Beta-Hydroxysteroid Dehydrogenase Type VII;
17-Beta-HSD 7;
17-Beta-Hydroxysteroid Dehydrogenase 7;
EC 1.1.1.51;
Estradiol 17 Beta-Dehydrogenase 7;
HSD17B7;
Hydroxysteroid (17-Beta) Dehydrogenase 7 =Amino Acid, Peptide, or Protein; Enzyme
13. (11Beta,17beta)-9-fluoro-11,17-dihydroxy-17-methylandrost-4-en-3-one
[A halogenated derivative of 17-alpha-methyltestosterone. Similar to testosterone, fluoxymesterone binds to and activates specific nuclear receptors, resulting in an increase in protein anabolism, a decrease in amino acid catabolism, and retention of nitrogen, potassium, and phosphorus. This agent also may competitively inhibit prolactin receptors and estrogen receptors, thereby inhibiting the growth of hormone-dependent tumor lines. Fluoxymesterone is approximately five times more potent than methyltestosterone. (NCI04) ( NCI )] (UMLS (NCI) C0016366) =Steroid; Pharmacologic Substance; Hormone =Androstenediols;
Steroids, Fluorinated;
[HS100] ANDROGENS/ANABOLICS;
=FLUOXYMESTERONE 10 MG;
FLUOXYMESTERONE 2 MG;
FLUOXYMESTERONE 5 MG;
63. 17 Beta-OH-7 beta, 17 alpha-dimethyl-androst-4-ene-3-one
[A 17-alkylated orally active androgenic steroid. Calusterone may alter the metabolism of estradiol and reduce estrogen production. (NCI04) ( NCI )] (UMLS (NCI) C0006790) =Steroid; Pharmacologic Substance
14. (11beta-21-[4-[4-[bis(2-chloroethyl)amino]phenyl]-1-oxobutoxy]-11,17-dihydroxypregna-1,4-diene-3,20-dione
[Ester of CHLORAMBUCIL and PREDNISOLONE used as a combination alkylating agent and synthetic steroid to treat various leukemias and other neoplasms. It causes gastrointestinal and bone marrow toxicity. ( MSH )] (UMLS (NCI) C0032949) =Steroid; Pharmacologic Substance ;
64. 17-Beta Hydroxysteroid Dehydrogenase
[Expressed in many peripheral tissues (high in placenta) by human HSD17B2 Gene (SDR Family), 387-aa 43-kDa Hydroxysteroid 17-Beta Dehydrogenase 2 is a potential type II membrane protein enzyme with an N-terminal type II signal-anchor motif and a C-terminal ER retention motif, likely associated with ER membranes, that uses NADH in the oxidative inactivation metabolism of testosterone and androstenedione, as well as estradiol and estrone. HSD17B2 also has 3-beta-HSD activity and 20-alpha-HSD activity toward 20-alpha-dihydroprogesterone. (NCI) ( NCI )] (UMLS (NCI) C0014914) =Amino Acid, Peptide, or Protein; Enzyme ;
15. (17beta)-17-(1-Oxopropoxy)androst-4-en-3-one
[A short acting oil-based injectable formulation of testosterone. Testosterone inhibits gonadotropin secretion from the pituitary gland and ablates estrogen production in the ovaries, thereby decreasing endogenous estrogen levels. In addition, this agent promotes the maintenance of male sex characteristics and is indicated for testosterone replacement in hypogonadal males. (NCI04) ( NCI )] (UMLS (NCI) C0039607) =Steroid; Pharmacologic Substance; Hormone =(17Beta)-17-hydroxyandrost-4-en-3-one;
=TESTOSTERONE PROPIONATE POWDER (GM);
TESTOSTERONE PROPIONATE 100 MG/ML;
TESTOSTERONE PROPIONATE 50 MG/ML;
TESTOSTERONE PROPIONATE 25 MG;
TESTOSTERONE PROPIONATE 25 MG/ML
65. 17beta-(estra-1,3,5(10)-triene-3,17-diol 3-[bis(2-chloroethyl)carbamate]
[A combination of the hormone estradiol (an estrogen) and nitrogen mustard (an anticancer drug). Used in the palliative therapy of prostate cancer. ( NCI )] (UMLS (NCI) C0014921) =Steroid; Pharmacologic Substance ;
=[AN000] ANTINEOPLASTICS;
(17beta)-Estra-1,3,5(10)-triene-3,17-diol;
Nitrogen Mustard Compound;
=Estramustine 17-(Dihydrogenphosphate) Disodium Salt;
16. (17Beta)-17-hydroxy-17-methylandrost-4-en-3-one
[A methylated synthetic androgen receptor agonist with anabolic effects. Methyltestosterone, mimicking testosterone, binds to cytosolic androgen receptors, and the subsequent nuclear transfer of the ligand-receptor complex induces transcription initiation of androgen responsive genes. The gene products are responsible for normal growth and development of male sex organs and secondary sex characteristics. The agent also causes retention of nitrogen, sodium, potassium, phosphorus, as well as calcium. ( NCI )] (UMLS (NCI) C0025826) =Steroid; Pharmacologic Substance; Hormone =(17Beta)-17-hydroxyandrost-4-en-3-one;
[HS100] ANDROGENS/ANABOLICS =METHYLTESTOSTERONE POWDER (GM);
METHYLTESTOSTERONE 1.25 MG;
METHYLTESTOSTERONE 2.5 MG;
METHYLTESTOSTERONE 25 MG;
METHYLTESTOSTERONE 5 MG;
METHYLTESTOSTERONE 10 MG;
66. 17Beta-Cyclopentanepropionate
[An eight-carbon ester form of Testosterone. The number of ester carbon atoms correlate with the half-life of the prodrug. Testosterone inhibits gonadotropin secretion from the pituitary gland and ablates estrogen production in the ovaries, thereby decreasing endogenous estrogen levels. In addition, this agent promotes the maintenance of male sex characteristics and is indicated for testosterone replacement in hypogonadal males. (NCI04) ( NCI )] (UMLS (NCI) C0076181) =Steroid; Pharmacologic Substance ;
=(17Beta)-17-hydroxyandrost-4-en-3-one;
=TESTOSTERONE CYPIONATE 100 MG/ML;
TESTOSTERONE CYPIONATE 50 MG/ML;
TESTOSTERONE CYPIONATE 200 MG/ML
17. (17Beta)-17-hydroxyandrost-4-en-3-one
[major androgenic hormone produced by the Leydig cells of the testes. ( CSP )] (UMLS (NCI) C0039601) =Steroid; Pharmacologic Substance; Hormone =androgen;
Androstenols;
[HS100] ANDROGENS/ANABOLICS;
=(17Beta)-17-hydroxy-17-methylandrost-4-en-3-one;
(17beta)-17-(1-Oxopropoxy)androst-4-en-3-one;
17Beta-Cyclopentanepropionate;
Testosterone enanthate;
(17beta)-17-(1-Oxopropoxy)androst-4-en-3-one;
17Beta-Cyclopentanepropionate;
Testosterone enanthate;
TESTOSTERONE POWDER (GM);
TESTOSTERONE 100 MG/ML;
TESTOSTERONE 25 MG;
TESTOSTERONE 25 MG/ML;
TESTOSTERONE 75 MG;
TESTOSTERONE 50 MG/ML;
TESTOSTERONE 5 GM;
TESTOSTERONE 2.5 GM;
TESTOSTERONE 4 MG;
TESTOSTERONE 6 MG;
TESTOSTERONE 2.5 MG;
TESTOSTERONE 5 MG
67. 17beta-Estradiol 17-Cyclopentylpropionate
[The cypionate salt form of estradiol, the most potent, naturally produced estrogen. Estradiol cypionate diffuses through the cell membrane and binds to and subsequently activates the nuclear estrogen receptor found in the reproductive tract, breast, pituitary, hypothalamus, liver, and bone. The activated complex binds to the estrogen response element on the DNA and activates the transcription of genes involved in the functioning of the female reproductive system and secondary sex characteristics. ( NCI )] (UMLS (NCI) C0059610) =Steroid; Pharmacologic Substance; Hormone =(17beta)-Estra-1,3,5(10)-triene-3,17-diol;
=ESTRADIOL CYPIONATE 5 MG;
ESTRADIOL CYPIONATE 2 MG/ML;
ESTRADIOL CYPIONATE 5 MG/ML;
18. (17beta)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol
[2ME2. A drug derived from estrogen that belongs to the family of drugs called angiogenesis inhibitors. It prevents the formation of new blood vessels that tumors need in order to grow. ( NCI )] (UMLS (NCI) C0046319) =Steroid; Pharmacologic Substance
68. 17Beta-hydroxyestra-1,3,5(10)-trien-3-yl Acetate
[The acetate salt form of estradiol, the most potent, naturally produced estrogen. Estradiol acetate diffuses through the cell membrane and binds to and subsequently activates the nuclear estrogen receptor found in the reproductive tract, breast, pituitary, hypothalamus, liver, and bone. The activated complex binds to the estrogen response element on the DNA and activates the transcription of genes involved in the functioning of the female reproductive system and secondary sex characteristics. ( NCI )] (UMLS (NCI) C1330622) Estradiol Acetate;
ESTRADIOL ACETATE UNIDENTIFIED;
ESTRADIOL ACETATE UNIDENTIFIED =Steroid; Pharmacologic Substance; Hormone
19. (17beta)-Estra-1,3,5(10)-triene-3,17-diol
[generally refers to the 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position; estradiol-17-beta is the most potent form of mammalian estrogenic steroids. ( CSP )] (UMLS (NCI) C0014912) =Steroid; Pharmacologic Substance; Hormone =(17beta)-Estra-1,3,5(10)-triene-3,17-diol;
Estrenes;
[HS300] ESTROGENS;
[GU500] ESTROGENS, VAGINAL =17beta-(estra-1,3,5(10)-triene-3,17-diol 3-[bis(2-chloroethyl)carbamate];
17beta-Estradiol 17-Cyclopentylpropionate;
ESTRADIOL VALERATE;
Estradiol Phosphate Polymer;
ESTRADIOL 17-BETA 1 MG;
(17beta)-Estra-1,3,5(10)-triene-3,17-diol;
17beta-Estradiol 17-Cyclopentylpropionate;
ESTRADIOL VALERATE;
84 HR Estradiol 0.00156 MG/HR Transdermal Patch [Vivelle-Dot];
84 HR Estradiol 0.00312 MG/HR Transdermal Patch [Vivelle-Dot];
84 HR Estradiol 0.00417 MG/HR Transdermal Patch [Vivelle-Dot];
84 HR Estradiol 0.00208 MG/HR Transdermal Patch [Vivelle-Dot];
ESTRADIOL MISC. POWDER (GM);
ESTRADIOL 0.5 MG;
ESTRADIOL 1 MG;
ESTRADIOL 2 MG;
ESTRADIOL 0.025 MG;
84 HR Estradiol 0.00104 MG/HR Transdermal Patch [Vivelle-Dot];
ESTRADIOL 0.01 %;
ESTRADIOL 0.0375 MG;
ESTRADIOL 0.05 MG;
ESTRADIOL 0.075 MG;
ESTRADIOL 0.1 MG;
ESTRADIOL 25 MCG
69. 2 benzazine
[bicyclic aromatic ring structure with one meta nitrogen. ( CSP )] (UMLS (CSP) C0022248) =Organic Chemical =2-Ring Heterocyclic Compound;
nitrogenous heterocyclic compound =bicuculline;
debrisoquin;
PAPAVERINE;
NELFINAVIR;
Atracurium;
emetine;
PAPAVERINE;
4H-Pyrazino(2,1-a)isoquinolin-4-one, 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-;
doxacurium;
mivacurium;
moexipril;
QUINAPRIL;
SAQUINAVIR;
NELFINAVIR
20. (17beta)-Estra-1,3,5(10)-triene-3,17-diol 3-Benzoate
[The synthetic benzoate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. As the primary, most potent estrogen hormone produced by the ovaries, estradiol binds to and activates specific nuclear receptors. This agent exhibits mild anabolic and metabolic properties, and increases blood coagulability. (NCI04) ( NCI )] (UMLS (NCI) C0167626) =Steroid; Pharmacologic Substance; Hormone
70. 2'-Beta-Fluoro-2',3'-Dideoxyadenosine
[A synthetic purine fluoro-dideoxyadenosine derivative, antiviral Lodenosine acts as a reverse transcriptase inhibitor. Although used in clinical trials for treatment of human immunodeficiency (HIV), Lodenosine induces liver or kidney damage and its use has been reconsidered. (NCI04) ( NCI )] (UMLS (NCI) C0649962) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
21. (17beta)-Estra-1,3,5(10)-triene-3,17-diol Dipropanoate
[The synthetic dipropionate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. As the primary, most potent estrogen hormone produced by the ovaries, estradiol binds to and activates specific nuclear receptors. This agent exhibits mild anabolic and metabolic properties, and increases blood coagulability. (NCI04) ( NCI )] (UMLS (NCI) C0059618) =Steroid; Pharmacologic Substance; Hormone
71. 2,1,3-Benzothiadiazol-4-amine, 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-, Monohydrochloride
[The hydrochloride salt form of tizanidine, an imidazoline derivative structurally similar to clonidine and an adrenergic agonist with muscle relaxant property. Tizanidine stimulates alpha2-adrenergic receptors in the central nervous system, thereby inhibiting presynaptic release of norepinephrine and increasing the inhibitory effect on alpha motor neurons and motor reflexes. Tizanidine exerts some activity at the postsynaptic excitatory amino acid receptors and imidazoline receptors which may contribute to the overall reduction in facilitation of spinal motor neurons. Overall, tizanidine hydrochloride causes muscle relaxation, reduces spasticity and antinociceptive effects. ( NCI )] (UMLS (NCI) C0771735) 5-Chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole Hydrochloride;
Tizanidine Hydrochloride;
TIZANIDINE HYDROCHLORIDE PREPARATION =Organic Chemical; Pharmacologic Substance =TIZANIDINE;
=TIZANIDINE HYDROCHLORIDE 4 MG;
TIZANIDINE HYDROCHLORIDE 2 MG
22. (3-beta)-cholest-5-en-3-ol 4-(bis(2-chloroethyl)amino)benzeneacetate
[A steroidal nitrogen mustard with antineoplastic and mutagenic activities. After attachment to cell-surface steroid receptors and uptake, phenesterin enters the nucleus where it alkylates macromolecules, resulting in decreased cell proliferation. (NCI04) ( NCI )] (UMLS (NCI) C0070556) =Organic Chemical; Pharmacologic Substance ;
72. 2,3-Benzfluoranthene
[A colorless, aromatic hydrocarbon consisting of five fused rings and formed by the incomplete burning of organic matter. Benzo(b)fluoranthene is primarily found in gasoline exhaust, tobacco and cigarette smoke, coal tar, soot, amino acids and fatty acid pyrolysis products. This substance is used only for research purposes. Benzo(b)fluoranthene is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0053199) =Organic Chemical; Hazardous or Poisonous Substance ;
23. (3-beta,17-alpha)-19-Norpregn-4-en-20-yne-3,17-diol Diacetate
[The diacetate salt form of ethynodiol, a semi-synthetic progestational hormone agonist. Ethynodiol diacetate binds to cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor mediated gene expression. As a result of the negative feedback mechanism, luteinizing hormone (LH) release is inhibited, which leads to an inhibition of ovulation and an alteration in the cervical mucus and endometrium. In addition, ethynodiol diacetate has weak oestrogenic and androgenic properties. ( NCI )] (UMLS (NCI) C0015117) =Steroid; Pharmacologic Substance ;
=Norpregnenes;
ETHYNODIOL =ETHYNODIOL DIACETATE 1 MG
73. 2-.beta.-D-Ribofuranosyl-4-thiazolecarboxamide
(UMLS (NCI) C0092663) =Organic Chemical; Pharmacologic Substance
24. (3beta)-3-Hydroxy-lup-20(29)-en-28-oic Acid
[A pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) with antiinflammatory, anti-HIV and antineoplastic activities. Betulinic acid induces apoptosis through induction of changes in mitochondrial membrane potential, production of reactive oxygen species, and opening of mitochondrial permeability transition pores, resulting in the release of mitochondrial apogenic factors, activation of caspases, and DNA fragmentation. Although originally thought to exhibit specific cytotoxicity against melanoma cells, this agent has been found to be cytotoxic against non-melanoma tumor cell types including neuroectodermal.and brain tumor cells. ( NCI )] (UMLS (NCI) C0053530) =Organic Chemical; Pharmacologic Substance ;
74. 2-Benzimidazolinebutryric acid, 1-methyl-5-bis(2-chloroethyl)amino-, hydrochloride
[The hydrochloride salt of bendamustine, a novel alkylating agent of the nitrogen mustard family with antitumor activity. Bendamustine, chemically related to the alkylator chlorambucil, has three active moieties: an alkylating group, in common with the nitrogen mustard family; a benzimidazole ring, which may act as a purine analog; and a butyric acid side-chain. This agent undergoes extensive first-pass metabolism by cytochrome p450 enzymes in vivo. One of the hydroxy metabolites, beta-hydroxybendamustine, alkylates and crosslinks macromolecules, thereby resulting in DNA, RNA and protein synthesis inhibition, and subsequently inducing apoptosis. ( NCI )] (UMLS (NCI) C0772139) Bendamustin Hydrochloride;
Bendamustine Hydrochloride =Organic Chemical; Pharmacologic Substance ;
25. (3beta)-Stigmast-5-en-3-ol
(UMLS (NCI) C0106127) =Steroid; Pharmacologic Substance
75. 2-benzofurancarboximide,N-(2-((1-(chloromethyl)-1,6-dihydro-8-methyl-5-(((phenylamino)carbonyl0oxy0benzo(1,2-b:4,3-b')dipyrrol-3(2H0-yl)carbonyl-1H-indol-5-yl)-6-(diethylamino)-,(S)
[An anticancer drug that belongs to the family of drugs called alkylating agents. ( NCI )] (UMLS (NCI) C0172048) =Organic Chemical; Pharmacologic Substance ;
26. (3beta,16beta,17alpha,18beta,20alpha)-11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic Acid Methyl Ester
[alkaloid isolated from the root of Rauwolfia species, used as an antihypertensive and sedative. ( CSP )] (UMLS (NCI) C0035179) =Organic Chemical; Pharmacologic Substance =rauwolfia alkaloid;
tranquilizer;
[CV490] ANTIHYPERTENSIVES, OTHER;
=RESCINNAMINE;
DESERPIDINE;
RESERPINE 0.25 MG;
RESERPINE 0.1 MG;
RESERPINE 0.125 MG
76. 2beta,16beta-Dipiperidino-5alpha-androstane-3alpha,17beta-diol Diacetate Dimethobromide
[The bromide salt form of pancuronium, a synthetic, long-acting ammonio steroid muscle relaxant with curarimimetic, some antimuscarinic and sympathomimetic effects. Pancuronium bromide competitively binds to the nicotinic receptor at the neuromuscular junction, thereby preventing acetylcholine binding and resulting in skeletal muscle relaxation and paralysis. ( NCI )] (UMLS (NCI) C0030311) =Steroid; Pharmacologic Substance ;
=PANCURONIUM;
=PANCURONIUM BROMIDE 1 MG/ML;
PANCURONIUM BROMIDE 2 MG/ML
27. (3beta,20beta)-20-Carboxy-11-oxo-30-norolean-12-en-3-yl-2-O-beta-D-glucopyranuronosyl-alpha-D-glucopyranosiduronic Acid
[A widely used anti-inflammatory agent isolated from the licorice root. It is metabolized to GLYCYRRHETINIC ACID, which inhibits 11-BETA-HYDROXYSTEROID DEHYDROGENASES and other enzymes involved in the metabolism of CORTICOSTEROIDS. Therefore, glycyrrhizic acid, which is the main and sweet component of licorice, has been investigated for its ability to cause hypermineralocorticoidism with sodium retention and potassium loss, edema, increased blood pressure, as well as depression of the renin-angiotensin-aldosterone system. ( MSH )] (UMLS (NCI) C0061751) =Organic Chemical; Pharmacologic Substance ;
77. 3,4-Benzpyrene
[A crystalline, aromatic hydrocarbon consisting of five fused benzene rings and formed during the incomplete combustion of organic matter. 3,4-Benzpyrene is primarily found in gasoline and diesel exhaust, cigarette smoke, coal tar and coal tar pitch, charcoal-broiled foods and certain other foods, amino acids, fatty acids and carbohydrate pyrolysis products, soot smoke, creosote oil, petroleum asphalt and shale oils. This substance is used only for research purposes. 3,4-Benzpyrene is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0005052) =Organic Chemical; Hazardous or Poisonous Substance
28. (3beta,20beta)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oic Acid
[An agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise the drug is low in toxicity. ( MSH )] (UMLS (NCI) C0006979) =Steroid; Pharmacologic Substance
78. 3beta-Hydroxy-11-oxoolean-12-en-30-oic Acid Hydrogen cis-1,2-cyclohexanedicarboxylate
(UMLS (NCI) C0055717) =Organic Chemical; Pharmacologic Substance ;
29. (3beta,20beta)-3-Hydroxy-11-oxoolean-12-en-29-oic Acid
[An oleanolic acid from GLYCYRRHIZA that has some antiallergic, antibacterial, and antiviral properties. It is used topically for allergic or infectious skin inflammation and orally for its aldosterone effects in electrolyte regulation. ( MSH )] (UMLS (NCI) C0017986) =Organic Chemical; Pharmacologic Substance
79. 3beta-Hydroxyandrost-5-en-17-one
[major C19 steroid produced by the adrenal cortex; also produced in small quantities in the testis and the ovary; dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone; most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. ( CSP )] (UMLS (NCI) C0011185) =Steroid; Pharmacologic Substance; Hormone =adrenal cortex hormone;
androgen;
[HS000] HORMONES / SYNTHETICS / MODIFIERS;
Unclassified Ingredients =DEHYDROEPIANDROSTERONE (DHEA) CAP/TAB;
30. (3beta,5beta)-3-[(O-2,6-Dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy]-14-hydroxycard-20(22)-enolide
[A lipid soluble cardiac glycoside that inhibits the plasma membrane sodium potassium ATPase, leading to increased intracellular sodium and calcium levels and decreased intracellular potassium levels. In studies increased intracellular calcium precedes cell death and decreased intracellular potassium increase caspase activation and DNA fragmentation, causing apoptosis and inhibition of cancer cell growth. (NCI) ( NCI )] (UMLS (NCI) C0012258) =Steroid; Carbohydrate; Pharmacologic Substance; Biologically Active Substance =cardenolide;
[CV050] DIGITALIS GLYCOSIDES
80. 3beta-N-1-(N-(3-(4-Aminobutyl))-1,3-diaminopropane)-7alpha,24-dihydroxy-5alpha-cholestane 24-sulfate
(UMLS (NCI) C0213314) =Steroid; Pharmacologic Substance
31. (3beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol
[produced in human and other animal tissue by photoactivation (normally sunlight on skin) of 7-dehydrocholesterol. ( CSP )] (UMLS (NCI) C0008318) =Steroid; Pharmacologic Substance; Vitamin =Cholestenes;
Secosteroids;
sterol;
[VT500] VITAMIN D;
[VT509] VITAMIN D, OTHER;
TO BE DELETED INGREDIENT PREPARATIONS =Hydroxycholecalciferols;
CHOLECALCIFEROL/FISH LIVER OIL OINT,TOP;
CRITICARE HN LIQUID;
THICKENUP POWDER;
ULTRACAL TUBE-FEEDING LIQUID;
CHOLECALCIFEROL 133 UNT;
CHOLECALCIFEROL 400 IU;
CHOLECALCIFEROL 400 UNT/ML;
81. 5-(2-(4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2H-Indol-2-one Monohydrochloride
[The hydrochloride salt form of ziprasidone, a benzothiazolylpiperazine derivative and an atypical antipsychotic agent with an antischizophrenic property. Ziprasidone hydrochloride functions as an antagonist at the dopamine D2 and serotonin 5-HT2A and 5-HT1D receptors, and as an agonist at the 5-HT1A receptor. Ziprasidone hydrochloride also inhibits synaptic reuptake of serotonin and norepinephrine. The mechanism of action by which ziprasidone hydrochloride exerts its antischizophrenic effect is unknown but is potentially mediated through a combination of dopamine D2 and serotonin 5-HT2 antagonism. This agent also has antagonistic activity against histamine H1 and alpha-1-adrenergic receptors. ( NCI )] (UMLS (NCI) C0380392) =Organic Chemical; Pharmacologic Substance ;
32. (5-Benzoyl-1H-benzimidazol-2-yl)-carbamic Acid Methyl Ester
[A synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake. This results in a depletion of glycogen stores and leads to reduced formation of ATP required for survival and reproduction of the helminth. This eventually causes the helminths death. ( NCI )] (UMLS (NCI) C0025023) =Organic Chemical; Pharmacologic Substance ;
=Anthelminthics;
benzimidazole =MEBENDAZOLE 100 MG
82. 6,7 benzomorphan
[ ] (UMLS (CSP) C0178433) =Organic Chemical ;
=morphinan;
=cyclazocine;
PENTAZOCINE
33. (9beta,10alpha)-17-(Acetyloxy)-6-methylpregna-4,6-diene-3,20-dione
[The acetate salt form of megestrol, a synthetic derivative of the naturally occurring female sex hormone progesterone with potential anti-estrogenic and antineoplastic activity. Mimicking the action of progesterone, megestrol acetate binds to and activates nuclear progesterone receptors in the reproductive system, and causes the ligand-receptor complex to be translocated to the nucleus where it binds to and promotes expression of target genes. This leads to an alteration in protein synthesis, which modulates cell growth of reproductive tissues. Due to the negative feedback mechanism seen with progesterone, megestrol also blocks luteinizing hormone (LH) release from the pituitary gland, thereby leading to an inhibition of ovulation and an alteration in the cervical mucus and endometrium. Furthermore, without stimulation of LH, estrogen release from the ovaries is stopped, hence impedes the growth of estrogen-sensitive tumor cells. ( NCI )] (UMLS (NCI) C0065879) =Steroid; Pharmacologic Substance; Hormone =MEG;
=Megestrol 20 MG;
MEGESTROL ACETATE 200 MG/5ML;
MEGESTROL ACETATE 40 MG;
83. 9-Beta-D-arabinofuranosyl-9H-purine-6-amine Monohydrate
[A nucleoside antibiotic isolated from the bacterium Streptomyces antibioticus with antineoplastic activity. Vidarabine inhibits DNA polymerase, resulting in the inhibition of DNA replication in tumor cells. (NCI04) ( NCI )] (UMLS (NCI) C0042646) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
=adenosine;
arabinonucleoside;
[OP203] ANTIVIRALS, TOPICAL OPHTHALMIC;
=2-Fluoro-9-beta-arabinofuranosyladenine;
VIDARABINE 3 %;
34. (betaR,deltaR)-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid
[a synthetic lipid-lowering agent; an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase that catalyzes the conversion of HMG-CoA to mevalonate, an early and rate-limiting step in cholesterol biosynthesis. ( CSP )] (UMLS (NCI) C0286651) =Organic Chemical; Pharmacologic Substance =antihypercholesterolemic agent;
[CV350] ANTILIPEMIC AGENTS;
Heptanoic Acids;
pyrrole =Atorvastatin Calcium
84. BE
[A country in Western Europe, bordering the North Sea, between France and the Netherlands. (NCI) ( NCI )] (UMLS (NCI) C0004950) =Geographic Area
35. .beta.,.beta.'-Dichlorodiethylaniline
[An alkylating mustard with antineoplastic activity. Aniline mustard forms covalent linkages with nucleophilic centers, resulting in depurination, base miscoding and strand scission, and crosslinking of DNA strands, all of which contribute to its cytotoxicity. (NCI04) ( NCI )] (UMLS (NCI) C0003040) =Organic Chemical; Pharmacologic Substance
85. Be
[metallic element with the atomic symbol Be, atomic number 4, and atomic weight 9.01218; used in electronic devices and lasers and for windows in X-ray tubes, as well as in spacecraft construction for its high ratio of strength to weight; exposure to the element or its salts can lead to berylliosis. ( CSP )] (UMLS (NCI) C0005139) =Hazardous or Poisonous Substance; Element, Ion, or Isotope ;
36. .beta.,.beta.-Dimethylcysteine
[beta dimethyl analog of cysteine; USP lists as a chelating agent. ( CSP )] (UMLS (NCI) C0030817) =Amino Acid, Peptide, or Protein; Pharmacologic Substance =Amino Acids, Sulfur;
[MS100] ANTIRHEUMATICS;
chelating agent;
.beta.,.beta.-Dimethylcysteine =PENICILLAMINE 125 MG;
PENICILLAMINE 250 MG;
.beta.,.beta.-Dimethylcysteine;
86. Be++ element
[ ] (UMLS (CSP) C0920764) =Element, Ion, or Isotope
37. .beta.-2'-Deoxy-6-thioguanosine
[A thiopurine nucleoside derivative with antineoplastic activity. After conversion to the triphosphate, beta-thioguanine deoxyriboside is incorporated into DNA, resulting in inhibition of DNA replication. This agent is cytotoxic against leukemia cell lines and has demonstrated some activity against leukemia cells in vivo. Beta-thioguanine deoxyriboside demonstrates antineoplastic activity against 6-thioguanine-resistant tumor cells. (NCI04) ( NCI )] (UMLS (NCI) C0053376) =Organic Chemical; Pharmacologic Substance; Biologically Active Substance
87. BEACOPP
(UMLS (NCI) C0879265) Bleomycin/Cyclophosphamide/Doxorubicin/Etoposide/Prednisone/Procarbazine/Vincristine =Therapeutic or Preventive Procedure
38. .beta.-Carotene
[A vitamin A precursor. Beta carotene belongs to the family of fat-soluble vitamins called carotenoids. ( NCI )] (UMLS (NCI) C0053396) =Organic Chemical; Pharmacologic Substance; Vitamin =carotene;
[VT050] VITAMIN A;
TO BE DELETED INGREDIENT PREPARATIONS;
=VITAMIN A (AS ACETATE & BETA CAROTENE);
VITAMIN A (AS PALMITATE & BETA CAROTENE);
BETA CAROTENE 0.25 MG/240ML;
BETA CAROTENE 1.06 MG/L;
BETA CAROTENE 400 UNT;
BETA CAROTENE 6000 UNT;
Beta Carotene 25000 UNT;
Beta Carotene 1000 UNT;
Beta Carotene 50 MG;
Beta Carotene 10000 UNT;
Beta Carotene 30 MG;
Beta Carotene 25 MG
88. BEAD
[A solid dosage form in the shape of a small ball. (NCI) ( NCI )] (UMLS (NCI) C0991566) Bead Dosage Form;
Bead Dose Form;
Beads =Biomedical or Dental Material =Solid;
SolidDrugForm
39. .beta.-Cytosine arabinoside
[class of pyrimidine nucleoside analogs used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia; antimetabolite antineoplastic agents that inhibit the synthesis of DNA with actions specific for the S phase of the cell cycle; also have antiviral and immunosuppressant properties. ( CSP )] (UMLS (NCI) C0010711) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
=[AN300] ANTINEOPLASTICS, ANTIMETABOLITES;
arabinonucleoside;
cytidine;
cytosine nucleoside =1,3, 5-Triazin-2(1H)-one, 4-amino-1-.beta.-D- arabinofuranosyl- (9CI);
Cytarabine Liposome;
CYTARABINE 2 GM/VIL;
CYTARABINE 1 GM/VIL;
CYTARABINE 100 MG;
CYTARABINE 500 MG;
89. Bead-Like Arrangement of Elastic Fibers
(UMLS (NCI) C1332548) =Finding
40. .beta.-Pyrazomycin
[A nucleoside analog. Pyrazofurin potently inhibits orotidine 5'-monophosphate (OMP) decarboxylase, thereby interfering with de novo synthesis of uridine nucleotides and resulting in cytotoxicity. This agent also causes a rapid depletion of the pyrimidine deoxynucleotide pool, thereby inhibiting DNA synthesis and cell replication. (NCI04) ( NCI )] (UMLS (NCI) C0072661) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
90. Beagle
[The Beagle is a hardy, sturdy squarely-built, small hound, with a short coat in tri-color, red and white, orange and white, or lemon and white. The ears are long, wide and pendant. There are two height classes, 13-15 inches (33-38 cm.) and under 13 inches (33 cm.) Weight: 20-25 pounds (9-11 kg.) ( NCI )] (UMLS (NCI) C0324306) =Mammal
41. 06-Benzyl Guanine
[A drug that may improve the response of cancer cells to chemotherapy. ( NCI )] (UMLS (NCI) C0083812) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
91. beam line
[ ] (UMLS (CSP) C1655209) =Manufactured Object ;
42. 1 benzazine
[bicyclic aromatic ring structure with one ortho nitrogen. ( CSP )] (UMLS (CSP) C0034424) =Organic Chemical =2-Ring Heterocyclic Compound;
nitrogenous heterocyclic compound =chloroquine;
PRIMAQUINE;
quinolinate;
kynurenate;
cyanine;
Aminoquinolines;
Hydroxyquinolines;
MEFLOQUINE;
Nitroquinolines;
QUINIDINE;
(-)-Quinine;
Quinolones;
flosequinan;
SAQUINAVIR;
MONTELUKAST
92. beamline
[ ] (UMLS (CSP) C0872107) =Manufactured Object ;
43. 1, 4-Benzenedicarboximidamide, N, N''-bis[4-[imino(methylamino)methyl]phenyl]-, tetrahydrochloride
[One of 800 terephthalanilides synthesized and tested preclinically in the late 1950's and early 1960's. Chosen in the 1990's for further clinical investigation by the NCI's Project for the Review of Old Drugs because of its structure and activity spectrum. ( NCI )] (UMLS (NCI) C1510442) Amidino TIC;
Terephthalamidine, N, N''-bis[p-(methylamidino)phenyl]-, tetrahydrochloride =Organic Chemical; Pharmacologic Substance ;
93. bean
[ ] (UMLS (CSP) C0004896) =Food
44. 1,2-Benz(a)anthracene
[A crystalline, aromatic hydrocarbon consisting of four fused benzene rings, produced by incomplete combustion of organic matter. Benz(a)anthracene is primarily found in gasoline and diesel exhaust, tobacco and cigarette smoke, coal tar and coal tar pitch, coal combustion emissions, charcoal-broiled foods, amino acids, fatty acids and carbohydrate pyrolysis products, wood and soot smoke, and creosote, asphalt and mineral oils. This substance is used only for research purposes. Benz(a)anthracene is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0220794) =Organic Chemical; Hazardous or Poisonous Substance ;
94. bean pod mottle virus
[ ] (UMLS (CSP) C0598202) =Virus
45. 1,2-Benzenedicarboxylic Acid, Bis(2-ethylhexyl)
[listed as a plasticizer by USP and MeSH. ( CSP )] (UMLS (NCI) C0012197) =Organic Chemical; Pharmacologic Substance; Biomedical or Dental Material =phthalate;
95. bean rugose mosaic virus
[ ] (UMLS (CSP) C0598203) =Virus
46. 1,2-Benzisoxazole-3-methanesulfonamide
[A sulfonamide derivative with an anticonvulsant property. The exact mechanism of action remains to be elucidated. Zonisamide appears to block sodium and calcium channels, thereby stabilizing neuronal membranes and suppressing neuronal hypersynchronization. Although zonisamide shows affinity for the gamma-aminobutyric acid (GABA) /benzodiazepine receptor ionophore complex, it does not potentiate the synaptic activity of GABA. In addition, this agent also facilitates both dopaminergic and serotonergic neurotransmission. ( NCI )] (UMLS (NCI) C0078844) =Organic Chemical; Pharmacologic Substance =[CN400] ANTICONVULSANTS;
isoxazole =ZONISAMIDE 100 MG
96. Bean Syndrome
[A hemangioma present at birth. It is characterized by the presence of rubbery skin lesions. ( NCI )] (UMLS (NCI) C0346072) =Congenital Abnormality
47. 1,3-Benzenediol, 5-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-, Sulfate(2:1)(Salt)
[The sulfate salt form of metaproterenol, a short-acting and selective sympathomimetic beta-receptor agonist with bronchodilator activity. Metaproterenol sulfate binds beta-2 adrenergic receptors in bronchial smooth muscle and stimulates intracellular adenyl cyclase, thereby increasing the production of cyclic adenosine monophosphate (cAMP). Increased cAMP levels cause relaxation of bronchial smooth muscle, improve mucocliary clearance and reduce inflammatory cell mediator release, especially from mast cells. ( NCI )] (UMLS (NCI) C0025573) =Organic Chemical; Pharmacologic Substance =METAPROTERENOL;
=METAPROTERENOL SULFATE 0.4 %;
METAPROTERENOL SULFATE 0.6 %;
METAPROTERENOL SULFATE 0.65 MG/ACTUAT;
METAPROTERENOL SULFATE 10 MG;
METAPROTERENOL SULFATE 10 MG/5ML;
METAPROTERENOL SULFATE 20 MG;
METAPROTERENOL SULFATE 5 %;
97. bear
[The family of carnivorous or omnivorous bears, having massive bodies, coarse heavy fur, relatively short limbs, and almost rudimentary tails. ( MSH )] (UMLS (CSP) C0004897) =Mammal
48. 1,4 benzenediol
[1,4-dihydroxybenzene. ( CSP )] (UMLS (CSP) C0020306) =Organic Chemical; Pharmacologic Substance ;
=Hydroquinones;
phenol;
[DE900] DERMATOLOGICALS, TOPICAL OTHER;
=HYDROQUINONE 2 %;
HYDROQUINONE 3.3 %;
HYDROQUINONE 4 %;
98. Bear River Band of the Rohnerville Rancheria, Cali
(UMLS (HL7) C1554232) =Population Group =NativeEntityContiguous;
49. 1,4-Benzenediamine, 2,6-Dichloro-N(sup 1)-(4,5-dihydro-1H-imidazol-2-yl), Monohydrochloride
[The hydrochloride salt form of apraclonidine, a clonidine derivative with selective alpha-2-adrenergic agonistic property. When administered directly to teyes, apraclonidine hydrochloride enhances aqueous humor outflow and decreases aqueous production by vasoconstriction. It is used mostly in ophthalmic preparations for decreasing intraocular pressure. ( NCI )] (UMLS (NCI) C0304657) =Organic Chemical; Pharmacologic Substance ;
=4-aminoclonidine;
=APRACLONIDINE HYDROCHLORIDE 0.5 %;
APRACLONIDINE HYDROCHLORIDE 1 %
99. Beard's disease
[A mental disorder characterized by chronic fatigue and concomitant physiologic symptoms. ( MSH )] (UMLS (CSP) C0027804) =Mental or Behavioral Dysfunction ;
=Somatoform Disorders;
50. 1,4-Benzenedicarboximidamide
[A derivative of the phthalanilide compounds. Terephthalamidine belongs to a family of compounds which appear to reversibly bind to the minor groove of the DNA double helix but not intercalate DNA. This agent also has been suggested to form ionic complexes with many biological components in vitro, including nucleic acids, proteins and lipids. ( NCI )] (UMLS (NCI) C0076116) =Organic Chemical; Pharmacologic Substance
100. Bearded Collie
[The Bearded Collie is a medium-sized herding dog with a shaggy coat. This breed has a broad head, short muzzle and a shaggy coat all over the body, even under the chin. The color of the coat changes several times over the life of the dog. The adult coats come in any of the four colors, black, brown, blue, or fawn. Height: 20-22 inches (51-56 cm.) Weight: 40-60 pounds (18-27 kg.) ( NCI )] (UMLS (NCI) C0324337) =Mammal

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