- 1. 1, 4-Bis[methanesulfonoxy]butane
- [alkylating agent having a selective immunosuppressive effect on bone marrow; has been used in the palliative treatment of chronic myeloid leukemia. ( CSP )] (UMLS (NCI) C0006463) =Organic Chemical; Pharmacologic Substance; Hazardous or Poisonous Substance =Alkylating Activity;
[AN000] ANTINEOPLASTICS;
Butylene Glycols;
Mesylates;
mesylate;
Antineoplastic Alkylating Agent =BUSULFAN 6 MG/ML;
BUSULFAN 2 MG | - 26. Bis(diphenylphosphine)ethane
- (UMLS (NCI) C0053731) =Organophosphorus Compound; Pharmacologic Substance ;
|
- 2. 1,14-bis(ethylamino)-5,10-diazatetradecane
- [A polyamine analogue with antiproliferative and potential anti-diarrheal activities. Diethylhomospermine (DEHSPM) antagonizes polyamine activity via NMDA receptor glutamine binding site, thereby modulating inotropic stasis and reducing stool volume (anti-diarrhea). However, due to the toxic effects from metabolites of DEHSP, other tetramine derivatives with less toxicity are developed. ( NCI )] (UMLS (NCI) C0067118) =Organic Chemical; Pharmacologic Substance ;
| - 27. Bis(gamma-Glutamyl-L-cysteinylglycine) Disulfide
- [The oxidized disulfide form of glutathione (GSH) with potential protective activity. Glutathione disulfide (GSSG) is reduced by glutathione reductase to GSH. GSSG and GSH together play important roles in numerous redox reactions, such as those involved in the detoxification of harmful substances and free radicals, and in reactions preventing oxidative damage in erythrocytes. Upon ocular administration in irrigation solution, glutathione disulfide may exert a beneficial effect on the intracellular redox state of glutathione, thereby protecting the integrity and barrier function of the corneal endothelial cells. ( NCI )] (UMLS (NCI) C0061516) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Biologically Active Substance
|
- 3. 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-(methylaminocarbonyl)hydrazine
- (UMLS (NCI) C1450161) =Organic Chemical; Pharmacologic Substance
| - 28. Bis-(4-O-(2-O-(2-desoxy-2-methylamino-alpha-L-glucopyranosyl)-alpha-L-streptosyl)-L-streptidin)-trisulfat
- [The sulfate salt form of streptomycin, an aminoglycoside antibiotic derived from Streptomyces griseus with antibacterial property. Streptomycin sulfate binds to the S12 protein of the bacterial 30S ribosomal subunit, thereby inhibiting peptide elongation and protein synthesis, consequently leading to bacterial cell death. ( NCI )] (UMLS (NCI) C0038426) =Carbohydrate; Antibiotic ;
=Streptomycin;
=STREPTOMYCIN SULFATE 500 MG/ML;
STREPTOMYCIN SULFATE 5 GM/VIL;
STREPTOMYCIN SULFATE 1 GM/VIL;
|
- 4. 1,3-Bis(2,3-epoxypropoxy)benzene
- [A combustible, yellowish liquid with a slight phenolic odor. Diglycidyl resorcinol ether is used as a liquid spray epoxy resin and in the production of other epoxy resins. Exposure to this substance irritates the eyes, skin and respiratory tract and adversely affects the immune system, central nervous system, liver and gastrointestinal tract. This substance is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05) ( NCI )] (UMLS (NCI) C0058021) =Organic Chemical; Pharmacologic Substance ;
| - 29. Bis-Quinoline Analogue
- [A polypeptide quinoxaline antineoplastic antibiotic isolated from the bacterium Streptomyces echinatus. Echinomycin intercalates into DNA at two locations simultaneously in a sequence-specific fashion, thereby inhibiting DNA replication and RNA synthesis. (NCI04) ( NCI )] (UMLS (NCI) C0013508) =Amino Acid, Peptide, or Protein; Antibiotic
|
- 5. 1,3-Bis(2-chloroethyl)-1-nitrosourea
- [cell cycle phase nonspecific alkylating antineoplastic agent used in the treatment of brain tumors and various other cancers. ( CSP )] (UMLS (NCI) C0007257) =Organic Chemical; Pharmacologic Substance ;
=[AN000] ANTINEOPLASTICS;
nitrosourea;
Antineoplastic Alkylating Agent;
Unclassified Ingredients;
TO BE DELETED INGREDIENT PREPARATIONS;
=CAMUSTINE 7.7 MG;
CARMUSTINE 100 MG;
| - 30. BISACODYL
- [A synthetic pyridinylmethylene-diacetate ester derivative stimulant laxative, Bisacodyl acts with a parasympathetic effect directly on mucosal sensory nerves, increasing peristaltic contractions. It is used for occasional constipation, in pre- and postoperative treatment, and in conditions that require facilitation of defecation. (NCI04) ( NCI )] (UMLS (NCI) C0005632) =Organic Chemical; Pharmacologic Substance
|
- 6. 1,4-bis[[2-[(2-Hydroxyethyl)amino]ethyl]amino]9,10-anthracenedione
- [A topoisomerase II inhibitor of the anthrapyrazole family that causes covalent cross-links in DNA of tumor cells. ( NCI )] (UMLS (NCI) C0102923) =Organic Chemical; Pharmacologic Substance
| - 31. Bisantrene Dihydrochloride
- (UMLS (NCI) C0955176) Bisantrene HCL;
Bisantrene Hydrochloride;
=Organic Chemical; Pharmacologic Substance |
- 7. 1-bis(2-chloroethyl)-amino-1-oxo-2-aza-5-oxaphosphoridin monohydrate
- (UMLS (NCI) C0887682) 2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide monohydrate;
2-[bis(b-chloroethyl)amino]-1-oxa-3-aza-2-phosphacyclohexane-2-oxide monohydrate;
2-[di(chloroethyl)amino]-1-oxa-3-aza-2-phosphacyclohexane 2-oxide monohydrate;
2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate;
bis(2-chloroethyl)phosphamide cyclic propanolamide ester monohydrate;
Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester monohydrate;
CP monohydrate;
Cyclophosphamid monohydrate;
N,N-bis(2-chloroethyl)-N'-(3-hydroxypropyl)phosphorodiamidic acid intramolecular ester monohydrate;
N,N-bis(2-chloroethyl)-N',O-propylenephosphoric acid ester diamide monohydrate;
N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide monohydrate;
N,N-bis(b-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide monohydrate;
N,N-bis(beta-chloroethyl)-N',O-propylenephosphoric acid ester diamide monohydrate;
N,N-bis(beta-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide monohydrate =Organophosphorus Compound; Pharmacologic Substance ;
| - 32. Bisbenzimidazole
- [A fluorescent dye of benzimidazole derivative. Pibenzimol binds to AT-specific sites in the minor groove of duplex DNA and inhibits topoisomerase I, and DNA polymerase, thereby preventing DNA replication. This agent prolongs the G2 phase of the cell cycle and initiates apoptosis in tumor cells. (NCI04) ( NCI )] (UMLS (NCI) C0019832) =Organic Chemical; Pharmacologic Substance; Indicator, Reagent, or Diagnostic Aid
|
- 8. 2,2-bis(Bromomethyl)-1,3-Propanediol
- [A solid, white, organo-halide carcinogen with a musty odor that consists for 78% of 2,2-Bis(Bromomethyl)-1,3-Propanediol. BBMP is used in industry as a flame retardant in unsaturated polyester resins, in molded products and in rigid polyurethane foam. BBMP is mutagenic and carcinogenic in animals and is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0045288) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 33. bisexual
- [possessing both homosexual and heterosexual preferences; or true hermaphroditism, having gonads of both sexes. ( CSP )] (UMLS (CSP) C0178515) =Population Group ;
=sexual orientation;
|
- 9. 2,6-Bis(1,1-dimethylethyl)-4-methylphenol
- [2,6-di-tert-butyl-4-methylphonol, a perservative commonly used in packaged foods. ( CSP )] (UMLS (NCI) C0006507) =Organic Chemical; Pharmacologic Substance =Cresols;
food additive;
phenol;
Unclassified Ingredient Preparations =AQUA-A CREAM;
AQUADERM CREAM;
AQUADERM LOTION;
ALPHA KERI BAR SOAP;
KERI FACIAL SOAP;
BUTYLATED HYDROXYTOLUENE 100 GM | - 34. Bismuth Bi213 Monoclonal Antibody M195
- [A radioimmunoconjugate consisting of murine monoclonal antibody (M195) and bismuth 213 (Bi213). Monoclonal antibody M195 binds to CD33, a surface antigen expressed by myelogenous leukemia cells. Bismuth 213 is an isotope that emits short-ranged high-energy alpha particles. This radioimmunoconjugate selectively delivers alpha particle-mediated cytotoxicity to leukemic cells, thereby limiting the exposure of normal tissues to ionizing radiation. (NCI04) ( NCI )] (UMLS (NCI) C0935824) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Immunologic Factor
|
- 10. 2-bis[Cyclo(N-methyl-L-valyl-sarcosyl-L-prolyl-D-valyl-L-threonyl)]-1,9 dimethyl-4,6 3H-phenoxazinone-3
- [An anticancer drug that belongs to the family of drugs called antitumor antibiotics. ( NCI )] (UMLS (NCI) C0010934) =Amino Acid, Peptide, or Protein; Antibiotic =antineoplastic antibiotics;
Heterocyclic Compounds, 3-Ring;
cyclic peptide;
=DACTINOMYCIN 0.5 MG;
| - 35. Bismuth Bi213 Monoclonal Antibody M195/Cytarabine/Filgrastim
- (UMLS (NCI) C0935825) =Therapeutic or Preventive Procedure
|
- 11. 2-[bis(2-chloroethyl)amino]-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxaphosphorine 2-oxide
- [An orally bioavailable oxazaphosphorine prodrug with antineoplastic activity. Trofosfamide (TFF) is metabolized predominantly to the cyclophosphamide analogue ifosfamide (IFO), which is then metabolized by liver cytochrome P450s to the active isophosphoramide mustard (IPM). IPM alkylates DNA to form DNA-DNA cross-links, which may result in inhibition of DNA, RNA and protein synthesis, and ultimately lead to tumor cell apoptosis. ( NCI )] (UMLS (NCI) C0077375) =Organic Chemical; Pharmacologic Substance ;
| - 36. Bismuth Subcitrate
- [A mineral compound that is used to treat duodenal and gastric ulcers associated with Helicobacter pylori. (NCI) ( NCI )] (UMLS (NCI) C0106556) =Organic Chemical; Pharmacologic Substance
|
- 12. 2-[bis(2-chloroethyl)amino]-4-hydroperoxytetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
- [The active metabolite of the nitrogen mustard cyclophosphamide with potent antineoplastic and immunosuppressive properties. Perfosfamide alkylates DNA, thereby inhibiting DNA replication and RNA and protein synthesis. (NCI04) ( NCI )] (UMLS (NCI) C0163054) =Organophosphorus Compound; Pharmacologic Substance ;
| - 37. Bismuth Subcitrate/Metronidazole/Omeprazole/Tetracycline
- (UMLS (NCI) C0677813) =Therapeutic or Preventive Procedure
|
- 13. 3,5-Bis(acetylamino)-2,4,6-triiodobenzoic Acid
- [A commonly used x-ray contrast medium. As DIATRIZOATE MEGLUMINE and as Diatrizoate sodium, it is used for gastrointestinal studies, angiography, and urography. ( MSH )] (UMLS (NCI) C0012004) =Organic Chemical; Indicator, Reagent, or Diagnostic Aid ;
=[DX102] IONIC CONTRAST MEDIA;
=1-Deoxy-1-(methylamino)-D-glucitol 3,5-diacetamido-2,4,6-triiodobenzoate (salt);
3,5-Diacetamido-2,4,6-triiodobenzoic Acid, Sodium Salt | - 38. Bismuth Subsalicylate
- [A bismuth salt of salicylic acid. Little absorbed from the gastrointestinal tract, bismuth subsalicylate exerts a local effect on the gastric mucosa, coating it and protecting it from the corrosive effects of acid and pepsin. This agent also has local antimicrobial properties. (NCI04) ( NCI )] (UMLS (NCI) C0053792) =Organic Chemical; Pharmacologic Substance ;
=Bi element;
Organometallic Compound;
Salicylates;
=BISMUTH RESORCIN COMPOUND;
CODEINE 16MG/BI SUBSALICYLATE/KAOLIN/PECTIN/15ML SUSP;
BISMUTH SUBSALICYLATE 262 MG;
BISMUTH SUBSALICYLATE 300 MG;
bismuth subsalicylate 35 MG/ML;
BISMUTH SUBSALICYLATE 260 MG/30ML;
bismuth subsalicylate 15.3 MG/ML;
BISMUTH SUBSALICYLATE 102 MG;
BISMUTH SUBSALICYLATE 112 X 262.4 MG;
BISMUTH SUBSALICYLATE 262 MG/15ML |
- 14. 3,6-bis-(2-piperidinoethoxyl)acridine trihydrochloride
- (UMLS (NCI) C0055843) =Organic Chemical; Pharmacologic Substance ;
| - 39. Bisodium Sulfate
- [A white, inorganic crystalline compound with various industrial uses. Sodium sulfate is found in many common electrolyte solutions used in clinical diagnostic purpose. Since this agent is poorly absorbed in the body, and could draw water out of the cells, sometimes it is used as a cathartic or diuretic. ( NCI )] (UMLS (NCI) C0074769) =Pharmacologic Substance; Inorganic Chemical ;
=SULFATE;
Inactive Ingredient Preparations =PEDI-BATH SALTS;
SODIUM SULFATE 22.74 GM;
SODIUM SULFATE 5.7 GM;
|
- 15. 4,4'-Bis(dimethylamino)diphenylmethane
- [A yellow colored, combustible leaflet material that emits toxic fumes of nitrogen oxides when heated to decomposition. Michler's base is used as a chemical intermediate in the manufacture of dyes and for its hydrochloric salt and is also used as an analytical reagent in the determination of lead. Exposure to Michler's base irritates the skin and eyes and can lead to methemoglobinemia and respiratory tract distress. Michler's base is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0067320) =Organic Chemical; Pharmacologic Substance ;
| - 40. BISOPROLOL
- [A selective beta-1 adrenergic receptor antagonist with antihypertensive activity and devoid of intrinsic sympathomimetic activity. Bisoprolol selectively and competitively binds to and blocks beta-1 adrenergic receptors in the heart, thereby decreasing cardiac contractility and rate. This leads to a reduction in cardiac output and lowers blood pressure. In addition, bisoprolol prevent the release of renin, a hormone secreted by the kidneys that causes constriction of blood vessels. ( NCI )] (UMLS (NCI) C0053799) =Organic Chemical; Pharmacologic Substance ;
=Propanolamines;
[CV100] BETA-BLOCKERS/RELATED =BISOPROLOL FUMARATE;
|
- 16. 4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide Monohydrochloride
- [The hydrochloride salt form of minocycline, a broad-spectrum, semi-synthetic tetracycline antibiotic with antimicrobial properties. Minocycline hydrochloride exerts its bacteriostatic effect by binding to bacterial 30S ribosomal subunit and prevents binding of aminoacyl-tRNA to mRNA on the ribosomes during elongation step of protein translation. This leads to an inhibition of bacterial protein synthesis and consequently cell growth. ( NCI )] (UMLS (NCI) C0026186) =Organic Chemical; Antibiotic =MINOCYCLINE;
=MINOCYCLINE HYDROCHLORIDE 50 MG;
MINOCYCLINE HYDROCHLORIDE 100 MG;
MINOCYCLINE HYDROCHLORIDE 75 MG;
MINOCYCLINE HYDROCHLORIDE 50 MG/5ML;
MINOCYCLINE HYDROCHLORIDE 1 MG | - 41. Bisoprolol Fumarate/Hydrochlorothiazide
- [A combination of a synthetic antihypertensive phenoxy-2-propanol derivative and a diuretic thiazide used for hypertension, Bisoprolol Fumarate Hydrochlorothiazide acts as a selective beta-1 (cardio) adrenergic antagonist, without membrane stabilizing activity or intrinsic sympathomimetic activity. Hydrochlorothiazide affects renal tubular electrolyte reabsorption, increasing excretion of sodium and chloride. (NCI04) ( NCI )] (UMLS (NCI) C1302079) =Organic Chemical; Pharmacologic Substance
|
- 17. 4-[bis(2-chloroethyl)amino]-L-phenylalanine
- [4-bis-(2-chloroethyl)amino-L-phenylalanine; a bifunctional alkylating agent used as a DNA strand crosslinker and antineoplastic. ( CSP )] (UMLS (NCI) C0025241) =Amino Acid, Peptide, or Protein; Pharmacologic Substance ;
=[AN000] ANTINEOPLASTICS;
Bis(2-chloroethyl)methylamine;
Nitrogen Mustard Compound;
phenylalanine;
Antineoplastic Alkylating Agent;
=3-(p-(bis(2-chloroethyl)amino)phenyl)-L-Alanine, Hydrochloride;
MELPHALAN 2 MG;
| - 42. Bispecific Antibodies
- [Antibodies developed in the laboratory to recognize more than one protein on the surface of different cells. Examples include bispecific antibodies 2B1, 520C9xH22, mDX-H210, and MDX447. ( NCI )] (UMLS (NCI) C0206492) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Immunologic Factor
|
- 18. 5-(bis-(2-Chloroethyl) Amino) Uracil
- [Nitrogen mustard derivative of URACIL. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage. ( MSH )] (UMLS (NCI) C0041920) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
=Nitrogen Mustard Compound;
2, 4-Dioxopyrimidine;
Antineoplastic Alkylating Agent;
| - 43. Bispecific Antibody 4G7xH22
- [A bispecific antibody containing a 4G7 hybridoma secreting IgG1 antibody specific for B-lymphocytes and a monoclonal antibody targeting Fc gamma RI-expressing cells. ( NCI )] (UMLS (NCI) C0935815) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Immunologic Factor
|
- 19. 5-[3, 3-Bis(2-chloroethyl)-1-triazeno]imidazole-4-carboxamide
- [A synthetic derivative of imidazole with potent antineoplastic properties. Imidazole mustard alkylates DNA, preferentially at guanine residues, resulting in DNA interstrand crosslinks and inhibition of DNA replication and RNA and protein synthesis. (NCI04) ( NCI )] (UMLS (NCI) C0063382) =Organic Chemical; Pharmacologic Substance
| - 44. Bispecific Antibody 520C9XH22/Filgrastim
- (UMLS (NCI) C0281766) =Therapeutic or Preventive Procedure ;
|
- 20. BIS
- [Two times per week. (NCI) ( NCI )] (UMLS (NCI) C0556985) =Temporal Concept
| - 45. Bispecific Antibody 520C9XH22/Interferon Gamma
- (UMLS (NCI) C0281595) =Therapeutic or Preventive Procedure ;
|
- 21. bis hydroxycoumarin
- [ ] (UMLS (CSP) C0597794) =Organic Chemical; Pharmacologic Substance
| - 46. Bispecific Antibody MDX447
- [An antibody with potential antineoplastic activity. Specific for both the high-affinity immunoglobulin G (IgG) receptor CD64 and epidermal growth factor receptor (EGFR), bispecific antibody MDX447 may enhance cellular immune responses against EGFR positive cells, resulting in increased tumor cell lysis. (NCI04) ( NCI )] (UMLS (NCI) C0879492) BsAb MDX447;
MDX-447 =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Immunologic Factor |
- 22. Bis(1,1-dioxoperhydro-1,2,4-thiadiazinyl-4)-methane
- [A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called anti-infectives. ( NCI )] (UMLS (NCI) C0144567) =Organic Chemical; Pharmacologic Substance ;
| - 47. Bispecific Antibody MDX447/Lymphokine-Activated Killer Cells
- (UMLS (NCI) C0879493) =Therapeutic or Preventive Procedure
|
- 23. Bis(2-chloroethyl)methylamine
- [antineoplastic cytotoxic alkylating agent of the nitrogen mustard group. ( CSP )] (UMLS (NCI) C0025033) =Organic Chemical; Pharmacologic Substance; Hazardous or Poisonous Substance =Alkylating Activity;
[AN000] ANTINEOPLASTICS;
Bis(2-chloroethyl)methylamine;
mustard compound;
Nitrogen Mustard Compound;
Antineoplastic Alkylating Agent;
haloalkylamine;
=Bis(2-chloroethyl)methylamine;
4-[bis(2-chloroethyl)amino]-L-phenylalanine;
Bis(2-chloroethyl)methylamine Hydrochloride | - 48. bispecific monoclonal antibody
- [A monoclonal antibody that binds two different types of antigen. Bispecific monoclonal antibodies do not occur naturally; they must be made in the laboratory. ( NCI )] (UMLS (NCI) C0206491) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Immunologic Factor
|
- 24. Bis(2-chloroethyl)methylamine Hydrochloride
- [The hydrochloride salt form of mechlorethamine, a synthetic agent related to sulphur mustard with antineoplastic and immunosuppressive properties. Nitrogen mustard (a member of a family of chemotherapy agents including cyclophosphamide and chlorambucil) is an irritant and carcinogenic agent metabolized to a highly reactive ethylene immonium derivative; the ethylene immonium derivative alkylates DNA and inhibits DNA replication. This agent also exhibits lympholytic properties. (NCI04) ( NCI )] (UMLS (NCI) C0600266) =Organic Chemical; Pharmacologic Substance; Hazardous or Poisonous Substance =Bis(2-chloroethyl)methylamine;
=MECHLORETHAMINE HYDROCHLORIDE 10 MG | - 49. bisulfite
- [ ] (UMLS (CSP) C0063088) =Inorganic Chemical
|
- 25. Bis(diethylthiocarbamoyl) Disulfide
- [carbamate derivative used as an alcohol deterrent; it is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol; when alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome); it acts by inhibiting aldehyde dehydrogenase. ( CSP )] (UMLS (NCI) C0012772) =Organic Chemical; Pharmacologic Substance =[AD100] ALCOHOL DETERRENTS;
DDTC;
Disulfides;
thiocarbamate =DISULFIRAM 250 MG | - 50. [2,5-bis(1-aziridinyl)-3,6-dioxo-1,4-cyclohexadiene-1,4-diyl]biscarbamic acid diethyl ester
- [Diaziquone. An anticancer drug that is able to cross the blood-brain barrier and kill cancer cells in the central nervous system. ( NCI )] (UMLS (NCI) C0113600) =Organic Chemical; Pharmacologic Substance
|
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