- 1. BRF1
- [This gene plays a role in transcriptional initiation. ( NCI )] (UMLS (NCI) C1332448) BRF1 Gene;
BRF1 Homolog, Subunit of RNA Polymerase III Transcription Initiation Factor IIIB (S. Cerevisiae) Gene;
=Gene or Genome ;
| - 3. BRF2 Subunit of RNA Polymerase III Transcription Initiation Factor
- [RNA Polymerase III Transcription Initiation Factor BRF2, encoded by the BRF2 gene, is a 50-kD protein that is a subunit of RNA polymerase III transcription initiation factor. BRF2 is involved in the nucleation of a polymerase III-specific small nuclear RNA (snRNA) transcription initiation complex. BRF2 does not directly bind DNA but it interacts with the TATA-binding protein (TBP), and they then bind cooperatively to the polymerase III promoter region of snRNA. The BRF2 protein has a zinc ribbon domain and a core domain. The TBP/BRF2 complex does not have strict requirements for sequence motifs outside the TATA box. Arg235 and phe250 of TBP, and repeat 2 of the BRF2 core domain, are necessary for complex formation with DNA. BRF2 also forms a stable complex on the TATA box of the polymerase II-specific adenovirus major late promoter. (from OMIM 607013, LocusLink 55290, and NCI) ( NCI )] (UMLS (NCI) C0962150) BRF2, Subunit of RNA Polymerase III Transcription Initiation Factor, BRF1-Like;
BRFU;
FLJ11052;
RNA Polymerase III Transcription Initiation Factor BRF2;
TFIIIB50;
Transcription Factor IIB-Related Factor =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
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