- 1. 2-CdA/CLB
- (UMLS (NCI) C0281307) =Therapeutic or Preventive Procedure ;
| - 51. CD209
- [This gene plays a role in the regulation of host defense responses and mediates pathogen-binding properties. ( NCI )] (UMLS (NCI) C1332707) CD209 Antigen Gene;
CD209 Gene;
=Gene or Genome |
- 2. 2-CdA/CTX/PRED
- (UMLS (NCI) C0678010) =Therapeutic or Preventive Procedure
| - 52. CD21
- [Molecular sites on or in B-lymphocytes, follicular dendritic cells, lymphoid cells, and epithelial cells that recognize and combine with COMPLEMENT C3D. Human complement receptor 2 (CR2) serves as a receptor for both C3dg and the gp350/220 glycoprotein of HERPESVIRUS 4, HUMAN, and binds the monoclonal antibody OKB7, which blocks binding of both ligands to the receptor. ( MSH )] (UMLS (CSP) C0056184) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor
|
- 3. 2-CdA/IDA
- (UMLS (NCI) C0677832) =Therapeutic or Preventive Procedure ;
| - 53. CD22
- [This gene is involved in mediating the adhesion between B cells and is a molecular marker for B-cell precursor acute lymphocytic leukemia. ( NCI )] (UMLS (NCI) C1332708) CD22 Antigen Gene;
CD22 Gene;
=Gene or Genome |
- 4. 2-CdA/VP-16
- (UMLS (NCI) C0392926) =Therapeutic or Preventive Procedure ;
| - 54. CD235A
- [Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are resulted from gene recombinations between GYPA and GYPB. (from RefSeq) ( NCI )] (UMLS (NCI) C0017955) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 5. 2CDA
- [An anticancer drug that belongs to the family of drugs called antimetabolites. ( NCI )] (UMLS (NCI) C0092801) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance =2-Chloroadenosine;
[AN300] ANTINEOPLASTICS, ANTIMETABOLITES;
[AN000] ANTINEOPLASTICS;
Deoxyadenosines;
[IM600] IMMUNE SUPPRESSANTS;
deoxyadenosine =CLADRIBINE 1 MG/ML;
| - 55. CD25
- [The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolysis. (LocusLink) ( NCI )] (UMLS (NCI) C1101536) IL-2 Receptor;
IL2R;
IL-2R;
IL2RA;
Interleukin 2 Receptor;
Interleukin 2 Receptor Alpha;
Interleukin 2 Receptor, Alpha;
Low Affinity Interleukin 2 Receptor =Amino Acid, Peptide, or Protein; Receptor ;
|
- 6. C.Difficile Colitis
- (UMLS (NCI) C0238106) =Disease or Syndrome ;
| - 56. CD26
- [Cell-surface glycoproteins and serine protease, also known as dipeptidyl-peptidase IV, that play a role in T-lymphocyte activation. CD26 binds to adenosine deaminase on the T-cell surface. EC 3.4.14.5 ( MSH )] (UMLS (CSP) C0081937) =Amino Acid, Peptide, or Protein; Enzyme; Immunologic Factor
|
- 7. C3 Deficiency
- (UMLS (NCI) C1332655) =Disease or Syndrome ;
| - 57. CD271
- (UMLS (NCI) C0081935) =Organic Chemical; Pharmacologic Substance ;
|
- 8. C5 Deficiency
- (UMLS (NCI) C1332657) =Disease or Syndrome ;
| - 58. CD28
- [T lymphocyte surface molecule; involved in T cell activation and IL2 production. ( CSP )] (UMLS (NCI) C0075747) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor =CD antigen;
|
- 9. CD
- [A country in Central Africa, south of Libya. (NCI) ( NCI )] (UMLS (NCI) C0007928) =Geographic Area
| - 59. CD28
- [This gene plays several roles in cellular functions specific to the T-cell. ( NCI )] (UMLS (NCI) C1332709) CD28 Antigen (Tp44) Gene;
CD28 Gene;
=Gene or Genome |
- 10. CD
- [A country in Central Africa, northeast of Angola. (NCI) ( NCI )] (UMLS (NCI) C0043444) =Geographic Area ◊ (UMLS (NCI) C0056447) Therapeutic or Preventive Procedure
| - 60. CD3
- [T-lymphocyte marker that functions as a molecular bridge holding the T-cell antigen receptor to the cell surface, and coupling antigen- TCR binding to T-cell activation events. ( CSP )] (UMLS (NCI) C0108779) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
=CD antigen;
|
- 11. CD antigen
- [differentiation antigens (markers) of lymphocyte subsets on cell membrane which are defined by monoclonal antibodies. ( CSP )] (UMLS (CSP) C0003322) =Immunologic Factor
| - 61. CD30 Antigen
- [Expressed in activated T- and B-cells by human TNFRSF8 Gene (TNFR Superfamily) as distinct serine and tyrosine phosphorylated Long (595-aa, 64-kDa precursor type I membrane protein) and Short (cytoplasmic) isoforms, TNF Receptor 8 contains 6 TNFR-Cys repeats. A positive regulator of apoptosis and receptor for TNFSF8/CD30L, TNFRSF8 interacts with the TRAF1, TRAF2, TRAF3, and TRAF5 mediators of signal transduction and regulates gene expression through NF-Kappa-B activation. A Hodgkin's disease associated antigen, TNFRSF8 limits the proliferative potential of autoreactive CD8 effector T cells and protects against autoimmunity. (NCI) ( NCI )] (UMLS (NCI) C0054950) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor
|
- 12. CD molecule
- [ ] (UMLS (CSP) C0872129) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
| - 62. CD31 Antigen
- [A cell adhesion molecule present on virtually all monocytes, platelets, and granulocytes, CD31 is highly expressed on endothelial cells and concentrated at the junctions between them. An integral membrane glycoprotein that contains six extracellular Ig-like domains, one transmembrane domain, and a cytoplasmic domain, CD31 is most similar to the CAM subgroup of the Ig superfamily. PECAM1 is implicated in several functions, including transendothelial migration of leukocytes, angiogenesis, and integrin activation. Ig superfamily members mediate cell adhesion, or antigen recognition, T-cell receptors, and MHC molecules. A subgroup contains one or more cytoplasmic ITIM motifs. PECAM1 has six ITIMs and may serve as a negative regulator of platelet-collagen interactions that may limit growth of platelet thrombi on collagen surfaces. (from OMIM 173445 and NCI) ( NCI )] (UMLS (NCI) C0081939) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
|
- 13. CD ROM
- [An optical disk storage system for computers on which data can be read or from which data can be retrieved but not entered or modified. ( NCI )] (UMLS (CSP) C0079090) =Manufactured Object; Intellectual Product ;
| - 63. CD32
- [ ] (UMLS (CSP) C0054951) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor
|
- 14. CD(P)TH
- (UMLS (NCI) C0279323) =Therapeutic or Preventive Procedure
| - 64. CD32
- [Expressed as 4 alternative isoforms in monocytes, macrophages, polymorphonuclear cells, and natural killer cells (Isoform 1) by human FCGR2C Gene, IgG Fc Receptor IIC is a type I cell surface protein with 2 IgC2 domains and a low affinity receptor for aggregated IgG Fc region. FCGR2C binding to IgG initiates essential effector and regulatory cellular responses against foreign pathogens and soluble antigens that induce phagocytosis of antigen-antibody complexes, removing them from circulation, and modulate B-cell antibody production. FCGR2C contains two cytoplasmic ITAM activator motifs involved in cell activation upon receptor aggregation. Isoform 4 may be soluble. (NCI) ( NCI )] (UMLS (NCI) C0215037) =Amino Acid, Peptide, or Protein; Receptor ;
|
- 15. CD1 antigen
- [antigen presenting molecule encoded outside of the major histocompatibility complex. ( CSP )] (UMLS (CSP) C0054941) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
=CD antigen;
| - 65. CD32
- [Expressed as 3 alternative isoforms in monocytes, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B cells, platelets, and placental endothelial by human FCGR2B Gene, IgG Fc Receptor IIB is a type I cell surface protein with 2 IgC2 domains and the most broadly distributed low affinity receptor for aggregated IgG Fc region. FCGR2B binding to IgG initiates essential effector and regulatory cellular responses against foreign pathogens and soluble antigens that induce phagocytosis of antigen-antibody complexes, removing them from circulation, and modulate B-cell antibody production. FCGR2B contains a cytoplasmic ITIM motif involved in down modulation of previous cell activation by BCR, TCR or another Fc receptor; phosphorylated ITIM binds to PTPN6/SHP-1 SH2 domain. Chromosome translocation t(1;22)(q22;q11) leads to FCGR2B hyperexpression in a follicular lymphoma. (NCI) ( NCI )] (UMLS (NCI) C1452607) CD32 Antigen;
FCG2;
Fc-Gamma RIIB;
Fc-Gamma-RIIB;
FCGR2;
FCGR2B;
FcRIIB;
IGFR2;
IgG Fc Receptor IIB;
Low Affinity IgG Fc Fragment Receptor IIB;
Low Affinity Immunoglobulin Gamma Fc Region Receptor IIB;
=Amino Acid, Peptide, or Protein; Receptor |
- 16. CD100 Receptor
- [Expression of CD72 is restricted to B-lineage cells and is turned off in differentiated antibody-secreting plasma cells. CD72 may participate in signals for B-cell proliferation and differentiation. In the immune system, CD72 appears to be a receptor for leukocyte activation antigen, CD100. CD72 may also be the ligand for CD5, a receptor that regulates T-cell proliferation. (from OMIM 107272, SWISS-PROT P21854, and NCI) ( NCI )] (UMLS (NCI) C0081944) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
| - 66. CD32 Antigen
- [Expressed in monocytes, macrophages, neutrophils, eosinophils, platelets, NK cells, and T- and B-lymphocytes by human FCGR2A Gene, 281-aa (mature) IgG Fc Receptor IIA is a type I cell surface membrane protein with 2 extracellular IgC2 domains and a low affinity receptor for aggregated IgG Fc region. FCGR2A binding to IgG initiates essential effector and regulatory cellular responses against foreign pathogens and soluble antigens that induce phagocytosis of antigen-antibody complexes, removing them from circulation, and modulate B-cell antibody production. An Arg167His polymorphism affects efficiency of IgG2 recognition. (NCI) ( NCI )] (UMLS (NCI) C1448238) Fc-Gamma-RIIA;
CD32;
FCG2;
Fc-Gamma RIIA;
FcGR;
FCGR2;
FCGR2A;
FCGR2A1;
FcRIIA;
IGFR2;
IgG Fc Receptor IIA;
Low Affinity IgG Fc Fragment Receptor IIA;
Low Affinity Immunoglobulin Gamma Fc Region Receptor IIA;
=Amino Acid, Peptide, or Protein; Receptor ;
|
- 17. CD102
- [CD102. Intracellular Adhesion Molecule-2. ( NCI )] (UMLS (NCI) C1317964) CD102 Antigen;
ICAM2;
ICAM-2;
Intercellular Adhesion Molecule 2 =Amino Acid, Peptide, or Protein; Immunologic Factor | - 67. CD34
- [A protein found on the surface of some bone marrow and blood cells. ( NCI )] (UMLS (NCI) C0054953) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
=CD antigen;
|
- 18. CD105
- [Endoglin is a Transforming Growth Factor Receptor present on tumor vasculature. It is a marker of angiogenesis and a target for cancer therapy. ( NCI )] (UMLS (NCI) C0082420) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
| - 68. CD34
- [This gene is involved in hematopoiesis; however, a specific physiological function has yet to be identified. ( NCI )] (UMLS (NCI) C1332710) CD34 Antigen Gene;
CD34 Gene;
=Gene or Genome |
- 19. CD106
- [cytokine induced cell adhesion molecule present on activated endothelial cells, tissue macrophages, dendritic cells, bone marrow fibroblasts, myoblasts and myotubes; important for the recruitment of leukocytes to sites of inflammation. ( CSP )] (UMLS (CSP) C0078056) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
=Adhesion Molecule;
| - 69. CD36
- [This gene is involved in the regulation of cellular transport and adhesion. ( NCI )] (UMLS (NCI) C1366645) CD36 Antigen (Collagen Type I Receptor, Thrombospondin Receptor) Gene;
CD36 Gene =Gene or Genome |
- 20. CD11
- [A group of three different alpha chains (CD11a, CD11b, CD11c) that are associated with an invariant CD18 beta chain (ANTIGENS, CD18). The three resulting leukocyte-adhesion molecules (RECEPTORS, LEUKOCYTE ADHESION) are LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MACROPHAGE-1 ANTIGEN; and ANTIGEN, P150,95. ( MSH )] (UMLS (CSP) C0054942) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor
| - 70. CD38 molecule
- [membrane associated enzymes; converts NAD to cyclic ADP ribose; CD (2+) activates second messenger and ADP ribose. ( CSP )] (UMLS (CSP) C0075742) =Amino Acid, Peptide, or Protein; Enzyme; Immunologic Factor =CD antigen;
|
- 21. CD110
- [MPL encodes the Thrombopoietin Receptor, a member of the cytokine receptor superfamily. The mechanism by which TPO activates the TPOR appears similar to that of other hematopoietic cytokines that bind and induce receptor homodimerization. TPO regulates the production of multipotent hematopoietic progenitor cells and platelets. Lymphoid progenitors express IL7R and not MPL, whereas myeloid progenitors express MPL and not IL7R. The receptor for thrombopoietin may also represent a regulatory molecule specific for TPOR-dependent immune responses. TPOR contains two fibronectin type III-like domains and is a type I membrane protein. Two isoforms, MPL-K and MPL-P, are produced by alternative splicing and are co-expressed. (from OMIM 159530, SWISS-PROT P40238, and NCI) ( NCI )] (UMLS (NCI) C0218227) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor
| - 71. CD38-Negative Kinase
- [Expressed in prostate, testis, ovary, small intestine, and colon by human TNK1 Gene, 666-aa 72-kDa Non-Receptor Tyrosine Kinase 1 contains a putative N-terminal phosphotyrosine-binding domain, a tyrosine kinase domain, a putative SH3 domain, and a Pro-rich C-terminus containing SH3-binding motifs. The kinase domain includes an ATP-binding site and many conserved tyrosine kinase features. TNK1 shares highest homology with ACK, especially in the kinase and putative SH3 domains. Like SRC and JAK family kinases, TNK1 mediates intracellular signaling downstream of receptor activation. (NCI) ( NCI )] (UMLS (NCI) C0387990) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 22. CD114 Antigen
- [Colony Stimulating Factor 3, encoded by the CSF3 gene, is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Three transcript variants encoding three different protein isoforms have been found for this gene. (From LocusLink) ( NCI )] (UMLS (NCI) C0080090) =Amino Acid, Peptide, or Protein; Receptor
| - 72. CD3AP protein
- [ ] (UMLS (CSP) C0287353) =Amino Acid, Peptide, or Protein; Receptor ;
|
- 23. CD115
- [Colony stimulating factor-1 receptor protein (972 aa, ~108 kDa) is encoded by the c-fms proto-oncogene (CSF1R Gene). The protein is a transmember receptor for colony-stimulating factor and has tyrosine kinase activity. ( NCI )] (UMLS (NCI) C0080092) =Amino Acid, Peptide, or Protein; Enzyme; Immunologic Factor; Receptor
| - 73. CD3D
- [This gene is involved in immunity/defense via the activation of T cells. ( NCI )] (UMLS (NCI) C1413222) CD3D Antigen, Delta Polypeptide (TiT3 Complex) Gene;
CD3D Gene =Gene or Genome |
- 24. CD119
- [Expressed in monocytes, lymphocytes, and placenta by human IFNGR1 Gene (Type II Cytokine Receptor Family), monomeric 489-aa 90-kDa type I membrane protein Interferon Gamma Receptor Alpha Chain is a subunit of Ser/Thr phosphorylated heteromeric Interferon Gamma Receptor Complex, composed of IFNGR1 and IFNGR2, that activates macrophages in host defenses. Containing an N-terminal signal peptide, 7 potential N-linked glycosylation sites, several potential Ser- and Thr-rich O-linked glycosylation sites, 2 fibronectin type III domains, 2 Ig-like C2-type domains, a transmembrane domain, and a cytoplasmic portion, IFNGR1 acts as the receptor ligand-binding subunit. IFNGR2 constitutes an integral receptor accessory factor required for signal transduction. Defects in IFNGR1 are a cause of FDAMI. (NCI) ( NCI )] (UMLS (NCI) C1334195) CD119 Antigen;
CDw119;
IFN-Gamma-R1;
Immune Interferon Receptor;
Interferon Gamma Receptor Alpha Chain;
Interferon Gamma Receptor-1 =Amino Acid, Peptide, or Protein; Receptor ;
| - 74. CD3E
- [The CD3 complex mediates signal transduction. The TCR/CD3 complex of T lymphocytes consists of either a TCR Alpha/Beta or TCR Gamma/Delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled Gamma, Delta, Epsilon, Zeta, and Eta. CD3E Antigen, Epsilon Polypeptide (Tit3 Complex) is encoded by the CD3E gene. Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. (From LocusLink, Swiss-Prot and NCI) ( NCI )] (UMLS (NCI) C0759310) CD3E Antigen Epsilon Polypeptide;
CD3E Antigen, Epsilon Polypeptide (Tit3 Complex);
CD3E Protein;
CD3-Epsilon;
T3E;
T-Cell Antigen Receptor Complex, Epsilon Subunit of T3;
T-Cell Surface Antigen T3/LEU-4 Epsilon Chain;
T-Cell Surface Glycoprotein CD3 Epsilon Chain;
TCRE =Amino Acid, Peptide, or Protein; Immunologic Factor ;
|
- 25. CD11b
- [Part of the integrin CR3, aka Complement Receptor 3, the CD11b/CD18 heterodimer. (Fundamental Immunology, 3rd ed., William Paul, ed., Raven Press, NY 1993, pg 927) ( NCI )] (UMLS (NCI) C1136310) Complement Receptor Type 3, Alpha Subunit;
Integrin Alpha-M;
ITGAM;
MAC1 Alpha;
MO1 Alpha =Amino Acid, Peptide, or Protein; Immunologic Factor ;
| - 75. CD3E
- [This gene plays a role in immunity/defense and the positive regulation of cell proliferation. ( NCI )] (UMLS (NCI) C1332711) CD3E Antigen, Epsilon Polypeptide (TiT3 Complex) Gene;
CD3E Gene;
=Gene or Genome |
- 26. CD122
- [This protein is the beta subunit of the interleukin 2 receptor and is a type I membrane protein. It is involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. It plays a role in the T cell mediated immune response and is a member of the cytokine receptor family. (from LocusLink) ( NCI )] (UMLS (NCI) C1173313) IL2RB;
Interleukin 2 Receptor Beta;
Intermediate Affinity Interleukin 2 Receptor;
Medium Affinity Interleukin 2 Receptor;
P70-75;
=Amino Acid, Peptide, or Protein; Receptor ;
| - 76. CD3G
- [This gene is involved in development and immunity/defense. ( NCI )] (UMLS (NCI) C1413223) CD3G Antigen, Gamma Polypeptide (TiT3 Complex) Gene;
CD3G Gene =Gene or Genome |
- 27. CD123
- [Encoded by human IL3RA Gene (Type I Cytokine Receptor 5 Family), 378-aa 43-kDa (precursor) Interleukin 3 Receptor Alpha is a type I membrane protein with a box 1 motif for JAK interaction/activation; a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding; and the ligand-binding alpha subunit of a heterodimeric cytokine receptor for Interleukin 3. Receptor binding to IL3 depends on the signal transducing beta subunit, shared by IL3-, IL5-, and CSF2/GM-CSF receptors. (NCI) ( NCI )] (UMLS (NCI) C0758637) CD123 Antigen;
IL3R;
IL3RA;
IL3R-Alpha;
IL3RX;
Interleukin 3 Receptor;
Interleukin 3 Receptor Alpha;
Interleukin 3 Receptor Alpha Chain;
Low Affinity Interleukin 3 Receptor Alpha =Amino Acid, Peptide, or Protein; Receptor ;
| - 77. CD4
- [helper T-lymphocyte marker that functions as a receptor for MHC class II antigen; also acts as the receptor for HIV. ( CSP )] (UMLS (NCI) C0003323) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor
|
- 28. CD124
- [IL4R when complexed with the common gamma chain (IL2RG) serves as the high-affinity interleukin 4 (IL4) receptor. It plays a major role in immunoglobulin E (IgE) production. ( NCI )] (UMLS (NCI) C0123771) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor
| - 78. CD4
- [This gene is involved in the initiation of T-cell activation. ( NCI )] (UMLS (NCI) C1332714) CD4 Antigen (P55) Gene;
CD4 Gene;
=Gene or Genome ;
|
- 29. CD127
- [This protein is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor common gamma chain (IL2RG). It has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). (from LocusLink) ( NCI )] (UMLS (NCI) C0083032) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor
| - 79. CD4 lymphocyte
- [A type of white blood cell that helps stimulate immune system reactions. Helper T cells help activate cytotoxic T cells and macrophages by secreting cytokines. They also stimulate B cells to make antibodies. ( NCI )] (UMLS (CSP) C0039215) =Cell
|
- 30. CD130 Antigen
- [Widely expressed (not restricted to IL6 responsive cells) by human IL6ST Gene (Type I Cytokine Receptor 2 Family), heterodimeric type I membrane protein (isoform 1) and secreted (isoform 2) Interleukin 6 Signal Transducer contains 5 fibronectin type III domains, an Ig-like C2-type domain, a BOX 1 motif required for JAK interaction/activation, and a WSXWS motif necessary for protein folding, intracellular transport, and cell-surface receptor binding. Part of cytokine receptor complexes, IL6ST is a signal transducer dependent on receptor binding for activation by many cytokines (IL6, CNTF, LIF, IL11, CT1, and OSM) that can utilize gp130 in signal transmission. IL6ST may regulate myocyte apoptosis and have a role in embryonic development. Isoform 2 is an autoantigen in rheumatoid arthritis but it is not specific to RA. (NCI) ( NCI )] (UMLS (NCI) C1366325) gp130 Transducer Chain;
IL6ST;
Interleukin 6 Signal Transducer;
Interleukin Receptor Beta Chain;
Membrane Glycoprotein gp130 =Amino Acid, Peptide, or Protein; Receptor | - 80. CD40-Ligand/flt3 Ligand
- (UMLS (NCI) C0935847) =Therapeutic or Preventive Procedure
|
- 31. CD132
- [The interleukin 2 (IL2) receptor gamma chain (IL2RG) is an important signalling component of many interleukin receptors (e.g., IL2,IL4,IL7,IL9, and IL15) and is thus referred to as the common gamma chain. It is necessary for normal growth and differentiation of T cells, B cells, natural killer cells, glioma cells, and cells of the monocyte lineage. Mutations in this X-chromosome-linked gene cause X-linked severe combined immunodeficiency (XSCID). (from LocusLink and OMIM) ( NCI )] (UMLS (NCI) C1334204) Common Cytokine Receptor Gamma Chain;
Common Gamma Chain;
IL2RG;
Interleukin 2 Receptor Gamma;
Interleukin 2 Receptor, Gamma;
Interleukin 2 Receptor, Gamma Chain =Amino Acid, Peptide, or Protein; Receptor ;
| - 81. CD43 molecule
- [integral membrane sialoglycoprotein expressed on the surface of virtually all cells of hematopoietc origin; involved in signal transduction and adhesion. ( CSP )] (UMLS (CSP) C0074479) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
=CD antigen;
|
- 32. CD134 Ligand
- [OX40 ligand is a type II membrane protein and member of the tumor necrosis factor family. OX40L interaction with its receptor OX40 may induce T-cell activation. Treatment with an antibody against OX40 ligand (OX40L) prevents rheumatoid arthritis in a murine model of the disease. (from Eur J Immunol 2000. 30:2815, OMIM 603594, and NCI) ( NCI )] (UMLS (NCI) C0258911) =Amino Acid, Peptide, or Protein; Receptor
| - 82. CD44
- [transmembrane hyaluronate receptor family of molecules; mediates immune cell adhesion, motility, and immune cell cytokine release. ( CSP )] (UMLS (NCI) C0243982) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor =CD antigen;
|
- 33. CD14
- [CD antigen expressed on surface of monocytes, macrophages, eosinophils, neutrophils; lipopolysaccharide receptor; signals production of tumor necrosis factor. ( CSP )] (UMLS (NCI) C0108768) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor =CD antigen;
| - 83. CD44
- [This gene plays a role in cellular matrix adhesion and in lymphocyte activation. ( NCI )] (UMLS (NCI) C1332712) CD44 Antigen (Homing Function and Indian Blood Group System) Gene;
CD44 Gene;
=Gene or Genome ;
|
- 34. CD14
- [This gene plays a role in apoptosis and in ligand-binding interactions. ( NCI )] (UMLS (NCI) C1367477) CD14 Antigen Gene;
CD14 Gene =Gene or Genome | - 84. CD45
- [This protein is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. It is specifically expressed in hematopoietic cells. It has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. It also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. (RefSeq) ( NCI )] (UMLS (NCI) C0054961) =Amino Acid, Peptide, or Protein; Enzyme; Immunologic Factor
|
- 35. CD142 Antigen
- [coagulation factor important in the formation of extrinsic prothrombin converting principle in the extrinsic pathway of blood coagulation; derived from several sources in the body including brain and lungs. ( CSP )] (UMLS (NCI) C0040048) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
=Blood Coagulation Factor;
| - 85. CD46
- [A ubiquitously expressed complement receptor that binds COMPLEMENT C3B and COMPLEMENT C4B and serves as a cofactor for their inactivation. CD46 also interacts with a wide variety of pathogens and mediates immune response. ( MSH )] (UMLS (CSP) C0285488) =Amino Acid, Peptide, or Protein; Immunologic Factor
|
- 36. CD148
- [Expressed in all hematopoietic lineages by human PTPRJ Gene (PTP Family), 1337-aa 146-kDa (precursor) N- and O-glycosylated type I membrane Protein Tyrosine Phosphatase Receptor Type J is a receptor-type PTP with an extracellular region containing 9 fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic PTP catalytic domain. PTPRJ negatively regulates TCR signaling, possibly by interfering with phosphorylation of PLCG1 and LAT. PTPRJ also dephosphorylates the PDGF beta receptor, may be involved in UV-induced signal transduction, and may contribute to contact inhibition of cell growth. Defects in PTPRJ are found in cancers of colon, lung, and breast. (NCI) ( NCI )] (UMLS (NCI) C0289499) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 86. CD47
- [This gene is involved in the regulation of calcium levels in cellular matrix adhesion processes. ( NCI )] (UMLS (NCI) C1332713) CD47 Antigen (Rh-Related Antigen, Integrin-Associated Signal Transducer) Gene;
CD47 Gene;
=Gene or Genome ;
|
- 37. CD152
- [CTLA-4 is an inhibitory T-cell surface receptor for B7 ligands on antigen presenting cells. It contains an extracellular V-like domain, a transmembrane region, and a putative cytoplasmic domain. It shares significant homology with CD28. Both bind the same ligands, however CTLA-4 binds to B7 with a greater affinity. B7 antigen-presenting cells regulate T-cell activation by delivering antigen-independent stimulatory signals through CD28 and inhibitory signals through CTLA-4. While CD28 is on the membrane of resting T-cells, CTLA-4 is detectable only on cells activated after antigen presentation. A CTLA-4 splice variant with a deleted transmembrane segment is preferentially expressed in non-activated T-cells. Activation of lymphocytes results in the disappearance of sCTLA-4 followed by its gradual reappearance, whereas CTLA-4 increases after activation. CTLA-4 may play an inhibitory role in regulating lymphocyte expansion. (from OMIM 123890 and NCI) ( NCI )] (UMLS (NCI) C0111208) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
| - 87. CD5 molecule
- [lymphocyte marker expressed on T and the Ly-1 subset of B cells; sends accessory signals necessary for CD3-mediated T cell activation, possibly via phosphorylation of inositol phosphate; Ly-1 B cells have a propensity for autoantibody production. ( CSP )] (UMLS (CSP) C0054964) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
=CD antigen;
|
- 38. CD154
- [A cell surface marker on T-cells. A member of the TNF family. It regulates B cell function by engaging CD40 on the B cell surface. ( NCI )] (UMLS (NCI) C0167627) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
| - 88. CD5 Plus
- [ ] (UMLS (CSP) C0287022) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Immunologic Factor
|
- 39. CD16
- [expressed on natural killer cells, granulocytes, and monocytes; its gene has been mapped to chromosome 1. ( CSP )] (UMLS (NCI) C0108747) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor =CD antigen;
| - 89. CD50
- [ICAM3 is a ligand for LFA-1, a major receptor of T-cells, B-cells, and granulocytes that mediates the leukocyte adhesion reactions underlying many immune functions. The interaction of LFA-1 with ICAM provides essential accessory adhesion signals in many immune interactions, including those between T- and B-lymphocytes and cytotoxic T-cells and their targets. ICAM3 is potentially the most important ligand for LFA-1 in the initiation of the immune response. ICAM3 is closely related to ICAM1, consists of five Ig domains, and binds LFA-1 through its two N-terminal domains. (from OMIM 146631 and NCI) ( NCI )] (UMLS (NCI) C0123748) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
|
- 40. CD16
- [Expressed (as NA-1, NA-2, and SH allelic forms) specifically by neutrophils and stimulated eosinophils, human FCGR3B Gene encodes 233-aa 26-kDa (precursor) monomeric IgG Fc Receptor IIIB, a glycosylated (inhibits IgG3 interaction) low affinity receptor for monomeric or aggregated Fc region of IgG, attached to membrane by a GPI-anchor, and containing 2 IgC2 domains. FCGR3B also exists as a soluble receptor produced by proteolytic cleavage. Unlike FCGR3A, FCGR3B is not capable of mediating antibody-dependent cytotoxicity and phagocytosis; FCGR3B may serve as a trap for immune complexes in the peripheral circulation without activating neutrophils. Amino acid conservation between CD16, other Fc receptors, and related Ig suggest similar structures and modes of association. (NCI) ( NCI )] (UMLS (NCI) C0966831) CD16B;
Fc Receptor III-1;
FCG3;
Fc-Gamma RIII;
Fc-Gamma RIIIB;
Fc-Gamma RIII-Beta;
FCGR3;
FCGR3B;
FcR-10;
FcRIII;
FcRIIIB;
IgG Fc Receptor IIIB;
Low Affinity IgG Fc Receptor IIIB;
Low Affinity Immunoglobulin Gamma Fc Region Receptor III-B;
=Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor | - 90. CD54
- [LFA-1 is a receptor for ICAM1, a surface molecule constitutively expressed on some tissues and induced on others in inflammation. The interaction of LFA-1 with ICAM provides essential accessory adhesion signals in many immune interactions, including those between T- and B-lymphocytes and cytotoxic T-cells and their targets. ( NCI )] (UMLS (NCI) C0063695) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
|
- 41. CD161
- [Encoded by human KLRB1 Gene (C-Type Lectin Superfamily, NKRP1 Family) and preferentially expressed by natural killer lymphocytes and some peripheral T-cells, the type II membrane NKRP1A Protein (external C-terminus) contains a 158-amino acid extracellular domain with C-type lectin motifs, a 29-amino acid transmembrane domain, and a 38-amino acid cytoplasmic domain. C-type lectins, including NKRP1 glycoproteins, may regulate NK cell function. NKRP1A protein is 46% identical to rat and mouse NKRP1, and 26% identical to human NKG2A. (from LocusLink, OMIM, and NCI) ( NCI )] (UMLS (NCI) C0132638) =Amino Acid, Peptide, or Protein; Immunologic Factor
| - 91. CD56
- [immunoglobulin-like neuronal surface glycoprotein which binds to a variety of other cell adhesion proteins to mediate adhesion, guidance, and differentiation during neuronal growth; may contain covalent phospholipid. ( CSP )] (UMLS (NCI) C0282587) =Amino Acid, Peptide, or Protein; Neuroreactive Substance or Biogenic Amine =Adhesion Molecule;
nerve/myelin protein |
- 42. CD167A Antigen
- [Encoded by human DDR1 Gene (PTK Family, Insulin Receptor Subfamily), 913-amino acid 101 kD (precursor) Epithelial Discoidin Domain Receptor 1, a type I membrane protein homolog of mouse Ptk3, is largely expressed in epithelial cells of kidney, lung, gastrointestinal tract, and brain. DDR1 exhibits extracellular Discoidin I motifs; GLY/PRO-rich domains likely required for ligand or substrate interaction; a F5/8 type C domain; and a novel N-terminal region with homology to a factor VIII domain. The C-terminal catalytic domain has type II receptor tyrosine kinase motifs. Neurotrophin TRKs - TRKA, TRKB, and TRKC - regulate development and survival of specific neuronal lineages. Activated by type I-VI collagens, NTRK4 may be a non-neuronal receptor for a NGF or involved in cell-cell interactions or cell adhesion. (from Swiss-Prot Q08345 and NCI) ( NCI )] (UMLS (NCI) C0294276) =Amino Acid, Peptide, or Protein; Enzyme; Receptor
| - 92. CD58
- [This gene plays a role in facilitating contacts between helper T lymphocytes and antigen-presenting cells. ( NCI )] (UMLS (NCI) C1332715) CD58 Antigen, (Lymphocyte Function-Associated Antigen 3) Gene;
CD58 Gene;
=Gene or Genome ;
|
- 43. CD168 Antigen
- [Encoded by human HMMR Gene and expressed in normal breast tissue, the 724-amino acid 84 kD Hyaluronan-Mediated Motility Receptor is similar to murine Hmmr. A subunit of the HARC complex, the hyaluronan receptor is required for cell motility and may regulate ERK activity. Phosphorylation of several proteins, including pp125-FAK, occurs when Hyaluronan binds HMMR; FAK phosphorylation is necessary for disassembly of focal contacts and motility. HMMR is up regulated in response to wound healing. (from Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C0388570) =Amino Acid, Peptide, or Protein; Receptor ;
| - 93. CD6
- [ ] (UMLS (CSP) C0054967) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
|
- 44. CD184 Antigen
- [Encoded by human CXCR4 Gene (GPCR1 Family), widely expressed 39.7-kD SDF1/PBSF Receptor CXCR4 is a sulfated 352-amino acid integral membrane leukocyte-activating receptor for CXC chemokine SDF1/PBSF that signals intracellular calcium flux and contains common GPCR features; a 7-transmembrane region and putative glycosylation and phosphorylation sites. Responsible for B-cell lymphopoiesis, myelopoiesis, cardiogenesis, and GI tract vascularization, CXCR4 may be involved in CNS development and can mediate leukocyte and hematopoietic cell migration. It is a primary receptor for some HIV-2 viruses and a CD4 co-receptor for some HIV-1 viruses by promoting env-mediated fusion. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C0250501) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor
| - 94. CD62
- [P-Selectin is a cell surface adhesion molecule that mediates the interaction of activated endothelial cells or platelets with neutrophils and monocytes. The protein is detected in megakaryocytes and platelets, as well as in vascular endothelial cells, but not in other cell types. In endothelia, the protein is localized to the membranes of Weibel-Palade bodies, intracellular storage granules for von Willebrand factor. CD24 is a ligand for P-selectin. Sorting nexin-17 interacts with the cytosolic domain of P-selectin and may function in the intracellular trafficking of P-selectin. (from OMIM 173610 and NCI) ( NCI )] (UMLS (NCI) C0134835) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
|
- 45. CD19
- [This gene plays a role in signal transduction and regulates the response of B cells to antigens. ( NCI )] (UMLS (NCI) C1413206) CD19 Antigen Gene;
CD19 Gene =Gene or Genome | - 95. CD62E
- [Cell adhesion molecule and CD antigen that mediates neutrophil, monocyte, and memory T-cell adhesion to cytokine-activated endothelial cells. E-selectin recognizes sialylated carbohydrate groups related to the Lewis X or Lewis A family. ( NCI )] (UMLS (NCI) C0115305) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor
|
- 46. CD19, monoclonal antibody
- [A mouse anti-human CD19 monoclonal antibody (MoAb). CD19 as well as CD22 are cell surface antigens present on majority of B lymphocytes, including early B progenitor cells. Anti-CD19 MoAb, either alone or in combination with other immunotherapeutic agents, maybe used in management of B-cell malignancies. ( NCI )] (UMLS (NCI) C0796613) MoAb CD19;
Monoclonal Antibody CD19;
=Amino Acid, Peptide, or Protein; Pharmacologic Substance; Immunologic Factor | - 96. CD7
- [Expressed in thymocytes and mature T cells by human CD7 Gene (Immunoglobulin Superfamily), 240-aa 25-kDa (precursor) T-Cell Antigen CD7 is a cell surface type I transmembrane glycoprotein that interacts with SECTM1, contains an Ig-like domain, and is essential in T-cell interactions and in T-cell/B-cell interaction during early lymphoid development. One of the earliest antigens on cells of the T-lymphocyte lineage, CD7 is the most reliable clinical marker of T-cell acute lymphocytic leukemia. (NCI) ( NCI )] (UMLS (CSP) C0054968) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
|
- 47. CD2
- [leukocyte surface antigen long known as the sheep red blood cell receptor (SRBCR); involved in helper and cytotoxic T lymphocyte activation. ( CSP )] (UMLS (NCI) C0108773) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor =CD antigen;
| - 97. CD7
- [This gene plays a role in T-cell interactions and is a clinical marker for T-cell acute lymphocytic leukemia. ( NCI )] (UMLS (NCI) C1413236) CD7 Antigen (p41) Gene;
CD7 Gene =Gene or Genome |
- 48. CD2
- [This gene is involved in T-cell activation and immune recognition. ( NCI )] (UMLS (NCI) C1367475) CD2 Antigen (p50), Sheep Red Blood Cell Receptor Gene;
CD2 Gene =Gene or Genome | - 98. CD72
- [This gene plays a role in signal transduction that leads to B-cell differentiation. ( NCI )] (UMLS (NCI) C1332716) CD72 Antigen Gene;
CD72 Gene;
=Gene or Genome ;
|
- 49. CD2 Ligand
- [Lymphocyte Function-Associated Antigen-3 (LFA-3), encoded by the CD58 gene, is a member of the Ig gene superfamily and a ligand for CD2 via heterophilic adhesion between the N-terminal domains. LFA-3 glycoproteins have a wide distribution on hematopoietic and non-hematopoietic cells and are strongly expressed on macrophages. Interaction between CD2 and its counter-receptor, LFA-3, on opposing cells optimizes immune recognition, facilitating contacts between helper T-lymphocytes and antigen-presenting cells as well as between cytolytic effectors and target cells. (from OMIM 153420 and NCI) ( NCI )] (UMLS (NCI) C0081942) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor
| - 99. CD8
- [CD8 Antigen Beta Polypeptide-1 is encoded by the CD8 Antigen Beta Polypeptide-1 gene (CD8B1) located at 2p12 and expressed as alternative membrane-associated cell surface or secreted isoforms in most suppressor and cytotoxic T lymphocytes. CD8 Antigen Beta Polypeptide 1 glycoprotein exhibits significant homology to Ig variable light chains and mediates efficient cell-cell interactions in the immune system, as an alpha/alpha or alpha/beta coreceptor with T-cell receptor. CD8B1 recognizes antigen displayed in an MHC I context by antigen presenting cells. ( NCI )] (UMLS (NCI) C1332717) CD8 Antigen, Beta Polypeptide 1;
CD8B;
CD8B1;
LYT3;
T-Cell Glycoprotein CD8b =Amino Acid, Peptide, or Protein; Immunologic Factor |
- 50. CD209
- [A dendritic cell-specific receptor for ICAM-3. It can bind to HIV gp120, thereby transporting it to internal sites and facilitating trans infection of secondary lymphoid organs rich in T cells. ( NCI )] (UMLS (NCI) C0913092) CD209 Antigen;
CDSIGN;
DC-SIGN;
DC-SIGN1;
Dendritic Cell Specific Intercellular Cell Adhesion Molecule Grabbing Non-Integrin;
Dendritic Cell-Specific ICAM3-Grabbing Nonintegrin;
HIV gp120-Binding Protein;
=Amino Acid, Peptide, or Protein; Immunologic Factor | - 100. CD8 Antigen, Beta Polypeptide 1 (p37) Gene
- [This gene is involved in the mediation of cytotoxic T cells and class I major histocompatibility interactions. ( NCI )] (UMLS (NCI) C1367471) CD8B1;
CD8B1 Gene =Gene or Genome |
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