- 1. CD94
- [Preferentially expressed in NK lymphocytes, CD94 Antigen (179-amino acid, 20.5-kD CD94-A and 148-amino acid CD94 ALT) is encoded by KLRD1 Gene (C-Lectin Family) and may regulate NK cell function. A type II membrane protein (external C-terminus), CD94 contains a 147-amino acid extracellular domain with C-type lectin motifs, a 26-amino acid transmembrane domain, and a 7-amino acid cytoplasmic domain (absent in CD94 ALT). CD94 forms disulfide-bonded heterodimers with NKG2A, NKG2C, and NKG2E. Nonclassical MHC HLA-E protein ligand binds to CD94/NKG2A, CD94/NKG2B, and CD94/NKG2C NK cell receptors. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C0382839) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
| - 3. CD97
- [This gene plays a role in cellular adhesion and signal transduction. ( NCI )] (UMLS (NCI) C1332718) CD97 Antigen Gene;
CD97 Gene;
=Gene or Genome ;
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- 2. CD97
- [CD97 Antigen, encoded by the CD97 gene, is a founding member of the EGF-TM7 family of class II seven-span transmembrane (7-TM) molecules. CD97 Antigen is a glycoprotein present on the surface of most activated leukocytes and is a G protein-coupled receptor. This protein has an extended extracellular region with several N-terminal epidermal growth factor (EGF)-like domains, which mediate binding to its cellular ligand, decay accelerating factor (DAF, CD55), a regulatory protein of the complement cascade. The presence of structural features characteristic of extracellular matrix proteins and transmembrane proteins suggests that this protein is a receptor involved in both cell adhesion and signaling processes early after leukocyte activation. Alternative splicing generates two variants. CD97 Antigen has large N-terminal domain with five epidermal growth factor-like sequences which are differentially spliced. (From LocusLink and NCI) ( NCI )] (UMLS (NCI) C0300533) =Amino Acid, Peptide, or Protein; Immunologic Factor
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