- 1. CDK
- [nonEC. ( CSP )] (UMLS (CSP) C0243045) =Amino Acid, Peptide, or Protein; Enzyme =EC 2.7.1.37;
| - 14. CDK4B Inhibitor
- [Induced by TGF-beta, cyclin-dependent kinase 4 inhibitor B interacts with CDK4 and CDK6, and may mediate TGF-Beta induced cell cycle arrest. CDK4IB contains two ankyrin repeats and belongs to the CDKN2/p16(INK4) family. (from SWISS-PROT P42772, OMIM 600431, and NCI) ( NCI )] (UMLS (NCI) C0249219) =Amino Acid, Peptide, or Protein; Enzyme ;
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- 2. CDK Inhibitor Gene
- [The CDK Inhibitor Genes encode the CDK Inhibitor Proteins, a group of low molecular weight proteins that associate with cyclin-CDK complexes or CDKs alone and inhibit their activity. (From OMIM and NCI) ( NCI )] (UMLS (NCI) C0919539) Cyclin-Dependent Kinase Inhibitor Gene =Gene or Genome ;
| - 15. CDK5
- [A hetero-dimeric (catalytic/regulatory subunits) serine/threonine protein kinase involved in cell cycle control. Predominantly neuronal, Cdk5 belongs to the CDC2/CDKX subfamily, interacts with D1- and D3-type G1 Cyclins, and phosphorylates histone H1, Tau, Map2, NF-H, and NF-M. (from SWISS-PROT Q00535, OMIM 123831, and NCI) ( NCI )] (UMLS (NCI) C0249586) =Amino Acid, Peptide, or Protein; Enzyme ;
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- 3. CDK Inhibitor Protein
- [Encoded by Cyclin-Dependent Kinase Inhibitor Genes, Cyclin-Dependent Kinase Inhibitor Proteins are a group of low molecular weight proteins that associate with Cyclin/CDK complexes or CDKs alone, inhibiting their activity and regulating the cell cycle. (From OMIM and NCI) ( NCI )] (UMLS (NCI) C0919418) CDKI Protein;
Cyclin Kinase Inhibitor;
Cyclin-Dependent Kinase Inhibitor;
Cyclin-Dependent Kinase Inhibitors =Amino Acid, Peptide, or Protein; Biologically Active Substance | - 16. CDK5
- [This gene is involved in neuronal regulation and is involved in the development of the mammalian central nervous system. ( NCI )] (UMLS (NCI) C1332735) CDK5 Gene;
Cyclin-Dependent Kinase 5 Gene;
=Gene or Genome ;
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- 4. CDK-Interacting Protein 1
- [cyclin dependent kinase inhibitor which prevents cells from progressing into S phase of the cell cycle; also, causes a G1 block to cell cycle progression in response to antimitogenic stimuli or other environmental cues. ( CSP )] (UMLS (NCI) C0288472) =Amino Acid, Peptide, or Protein; Biologically Active Substance =enzyme inhibitor;
EC 2.7.1.37;
Cell Cycle Protein;
| - 17. CDK6 Inhibitor p18
- [Cyclin-Dependent Kinase Inhibitor 2C, encoded by the CDKN2C gene, is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with monomeric CDK4 or CDK6, and prevent the activation of the CDK kinases, thus control cell cycle G1 progression. It inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein Rb. Two alternatively spliced transcript variants of this gene encode an identical protein. This protein contains 4 ANK repeats and is found in pancreas and heart, with the highest levels in skeletal muscle. Inactivation of CDKN2C by point mutations may contribute to deregulated growth control in certain cell lines and/or tumors. (From LocusLink, Swiss-Prot and NCI) ( NCI )] (UMLS (NCI) C0292198) =Amino Acid, Peptide, or Protein; Biologically Active Substance
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- 5. CDK10
- [This gene is involved in G2/M cell cycle regulation. ( NCI )] (UMLS (NCI) C1332730) CDK10 Gene;
Cyclin-Dependent Kinase (CDC2-like) 10 Gene;
=Gene or Genome ;
◊ [Cyclin-Dependent Kinase 10, encoded by the CDK10 gene, is a protein that belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members bind to cyclin to form active holoenzymes that play a pivotal role in the regulation of the eukaryotic cell cycle and are known to be essential for cell cycle progression. This kinase has been shown to play roles in cellular proliferation and its function is limited to cell cycle G2-M phase. A variety of different transcripts exist, resulting from cryptic splice sites, exon skipping, insertion of intronic sequences, and exon scrambling. The splicing of this gene is complex. At least three alternatively spliced variants of this gene exist, one of which contains multiple non-ATG translation initiation sites. (From LocusLink, OMIM and NCI) ( NCI )] (UMLS (NCI) C1333180) CDK10 Protein; Cell Division Protein Kinase 10; Cyclin-Dependent Kinase 10; EC 2.7.1.-; PISSLRE Protein; Serine/Threonine-Protein Kinase PISSLRE; Amino Acid, Peptide, or Protein; Enzyme | - 18. CDKL2
- [This gene plays a role in signal transduction. ( NCI )] (UMLS (NCI) C1332736) CDKL2 Gene;
Cyclin-Dependent Kinase-Like 2 (CDC2-Related Kinase) Gene;
=Gene or Genome ;
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- 6. CDK2
- [This gene is involved in G2/M cell cycle regulation. ( NCI )] (UMLS (NCI) C1332733) CDK2 Gene;
Cyclin Dependent Kinase 2 Gene;
=Gene or Genome ;
| - 19. CDKN1A
- [This gene is a regulator of cell cycle progression at the G1 phase of the cell cycle. ( NCI )] (UMLS (NCI) C0249197) =Gene or Genome
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- 7. CDK2/Cyclin A-Associated Protein p45
- [Expressed by human SKP2 Gene (F-Box Family) as 3 alternative isoforms, alpha (42-aa 48-kDa), beta (410-aa), and gamma (442-aa), S-Phase Kinase-Associated Protein 2 contains an F-box domain and 10 tandem LRR repeats. SKP2 acts as a substrate recognition component of the SCF E3 ubiquitin ligase complex, which mediates ubiquitination and proteasomal degradation of target proteins involved in cell cycle progression, signal transduction, and transcription. SKP2 interacts with CUL1, SKP1, and CKS1, and with the Cyclin A/CDK2 complex as an essential element of Cyclin A/CDK2 S-Phase Kinase. Involved in the G1/S transition, SKP2 specifically recognizes phosphorylated CDKN1B/p27KIP predominantly in S phase and interacts with S-phase p19SKP1. CDKN1B/p27KIP degradation also requires CKS1. (NCI) ( NCI )] (UMLS (NCI) C0381943) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 20. CDKN1B
- [This protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. (LocusLink) ( NCI )] (UMLS (NCI) C0169665) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
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- 8. CDK2AP1
- [CDK2-Associated Protein 1, encoded by the CDK2AP1 gene, is a specific CDK2-associated protein that negatively regulates CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein also interacts with DNA polymerase alpha/primase and promotes the phosphorylation of the large p180 subunit, which suggests the regulatory role in DNA replication during S phase of the cell cycle. Reduction of CDK2AP1 protein expression is a frequent event in oral cancers and is a negative prognostic indicator in patients with surgically resected oral squamous cell carcinoma. Loss of CDK2AP1 protein expression may contribute to the multistep nature of oral carcinogenesis. (From LocusLink, PubMed and NCI) ( NCI )] (UMLS (NCI) C1332731) CDK2-Associated Protein 1;
CDKAP1;
Cyclin-Dependent Kinase 2-Associated Protein 1;
Deleted in Oral Cancer 1;
Deleted In Oral Cancer-1;
DOC1;
DOC-1 =Amino Acid, Peptide, or Protein; Biologically Active Substance ◊ [This gene is involved in cell cycle regulation. ( NCI )] (UMLS (NCI) C1332732) CDK2AP1 Gene; CDK2-Associated Protein 1 Gene; Gene or Genome ; | - 21. CDKN1B
- [This gene is involved in cell cycle regulation and cyclin regulation. ( NCI )] (UMLS (NCI) C1332737) CDKN1B Gene;
Cyclin Dependent Kinase Inhibitor 1B Gene;
=Gene or Genome ;
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- 9. CDK3
- [This gene is involved in cell cycle checkpoints. ( NCI )] (UMLS (NCI) C1332734) CDK3 Gene;
Cyclin-Dependent Kinase 3 Gene;
=Gene or Genome ;
| - 22. CDKN1C
- [This gene plays a regulatory role in the cell cycle. ( NCI )] (UMLS (NCI) C1366618) CDKN1C Gene;
Cyclin-Dependent Kinase Inhibitor 1C Gene =Gene or Genome |
- 10. CDK3
- [Cyclin-Dependent Kinase 3, encoded by the CDK3 gene, belongs to the SER/THR family of protein kinases. CDK3 can phosphorylate histone H1. CDK3 is involved in the control of the cell cycle. CDK3 participates in the G1-S transition at least primarily by binding to E2F-1, E2F-2, or E2F-3 through DP-1 and by enhancing their transcriptional activities. CDK3 also interacts with cyclin E and cyclin A and Ik3-1/Cables is a novel substrate for CDK3-mediated phosphorylation by CDK3/cyclin E and CDK3/cyclin A. (From LocusLink, PubMed and NCI) ( NCI )] (UMLS (NCI) C1447440) Cell Division Protein Kinase 3;
Cyclin-Dependent Kinase 3;
Cyclin-Dependent Protein Kinase 3;
EC 2.7.1.- =Amino Acid, Peptide, or Protein; Enzyme | - 23. CDKN2A Gene Deletion
- (UMLS (NCI) C0805508) =Finding ;
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- 11. CDK4
- [Cyclin-dependent kinase 4 is a key regulator of G1 PHASE of the CELL CYCLE. It partners with CYCLIN D to phosphorylate RETINOBLASTOMA PROTEIN. CDK4 activity is inhibited by CYCLIN-DEPENDENT KINASE INHIBITOR P16. ( MSH )] (UMLS (CSP) C0246957) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 24. CDKN2B
- [This gene is involved in cell cycle regulation and arrest. ( NCI )] (UMLS (NCI) C0809183) CDKN2B Gene;
Cyclin-Dependent Kinase Inhibitor 2B Gene =Gene or Genome ;
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- 12. CDK4
- [This gene is involved in G1 stage cell cycle progression. ( NCI )] (UMLS (NCI) C0694873) =Gene or Genome
| - 25. CDKN2C
- [This gene is involved in cell cycle inhibition and regulation. ( NCI )] (UMLS (NCI) C1332738) CDKN2C Gene;
Cyclin-Dependent Kinase Inhibitor 2C (p18, Inhibits CDK4) Gene;
=Gene or Genome ;
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- 13. CDK4 Inhibitor
- [Product of the CDKN2A gene. Also called p16(INK4). A tumor suppressor and a negative regulator of progression through G1. p16(INK4) interacts with CDK4/CDK6, inhibiting their interaction with Cyclin D and the phosphorylation of RB. ( NCI )] (UMLS (NCI) C0249880) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 26. CDKN3
- [This gene plays a role in cell cycle regulation. ( NCI )] (UMLS (NCI) C1332739) CDKN3 Gene;
Cyclin-Dependent Kinase Inhibitor 3 (CDK2-Associated Dual Specificity Phosphatase) Gene;
=Gene or Genome ;
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