- 1. GDNF
- [Glial cell derived neurotrophic factor enhances the survival and morphological differentiation of dopaminergic neurons and increases their uptake of dopamine. GDNF can rescue motor neurons from programmed cell death and death caused by axotomy. GDNF is a possible treatment for Parkinson disease because it can protect cells from the effect of the neurotoxin MPTP. GDNF is a ligand for the RET gene product and may contribute to Hirschsprung disease when mutated and combined with a mutant RET. (LocusLink) ( NCI )] (UMLS (NCI) C0207072) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 3. GDNF Family Receptor Alpha 2
- [GDNF Family Receptor Alpha 2, encoded by the human GFRA2 gene, is a member of the Glial Cell Line-Derived Neurotrophic Factor (GDNF) Receptor family. GDNF and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 is required for the development of the myenteric nerve plexus. This protein is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This receptor acts preferentially as a receptor for NTN compared to its other family member, GDNF Family Receptor Alpha 1. Two alternatively spliced transcript variants, long and short, have been described for this gene but their full length nature is not known. The short form is found in brain and placenta. This gene is a candidate gene for RET-associated diseases. (From LocusLink, OMIM, Swiss-Prot and NCI) ( NCI )] (UMLS (NCI) C1457885) GDNF Family Receptor Alpha-2;
GDNF Receptor Beta;
GDNFRB;
GDNFR-Beta;
GFRA2;
GFRA2 Protein;
GFR-Alpha 2;
Glial Cell Line Derived Neurotrophic Factor Receptor, Beta;
Glial Cell Line-Derived Neurotrophic Factor Receptor Beta;
Neurturin Receptor Alpha;
NRTNR-ALPHA;
NTNRA;
NTNR-Alpha;
PI-Linked Cell-Surface Accessory Protein;
RET Ligand 2;
RETL2;
TGF-Beta Related Neurotrophic Factor Receptor 2;
TRN Receptor, GPI-Anchored;
TRNR2;
=Amino Acid, Peptide, or Protein; Receptor |
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