UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
I I- I0 I1 I2 I3 I4 I5 I6 I7 I8 I9 IA IB IC ID IE IF IG IH II IK IL IM IN IO IP IQ IR IS IT IU IV IX
IKA IKK
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1. I Kappa B
[Interacting with p65 (RELA), widely expressed 36-38kDa unphosphorylated cytoplasmic ANK-repeat human I Kappa B Proteins A/B/E (NFKBI Family) inhibit NF-Kappa-B, trapping it in the cytoplasm. By complexing with NFKB, IKBs regulate NFKB transcription in cell adhesion, immune and proinflammatory responses, apoptosis, differentiation, and growth. Cytokine-activated serine phosphorylation of IKBs by IKBKA/IKBKB disables the NFKB inhibition by dissociation; promotes polyubiquitinated proteasome-dependent IKB degradation; and allows NFKB nuclear translocation, binding at kappa-B DNA motifs, and target gene transcription. (NCI) ( NCI )] (UMLS (NCI) C0167954) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
3. I kappa B beta
[ubiquitous inducible nuclear transcription factor that binds enhancer elements in many different cell types; is activated by pathogenic stimuli. ( CSP )] (UMLS (CSP) C0166033) =Amino Acid, Peptide, or Protein; Biologically Active Substance =transcription factor;
2. I Kappa B A
[One of a number of ankyrin-rich proteins known as IkappaB that interact with and regulate members of the Rel/NF-kappaB family of transcription factors. IkappaB-alpha is the inhibitory subunit of NF-kappaB. ( NCI )] (UMLS (NCI) C0126732) =Amino Acid, Peptide, or Protein; Biologically Active Substance
4. I-Kappa-B-Epsilon
[Expressed in spleen, testis, lung, kidney, pancreas, heart, placenta, brain, granulocytes, and macrophages by human NFKBIE Gene (NFKBI), 361-aa 38-kDa cytoplasmic I-Kappa-B-Epsilon contains 6 ANK repeats and preferentially interacts with p65 RELA homodimers and with p65-cRel heterodimers. By complexing with and trapping NF-Kappa-B in the cytoplasm, NFKBIE inhibits and likely regulates NFKB. Serine phosphorylation of NFKBIE results in proteasome-dependent degradation. (NCI) ( NCI )] (UMLS (NCI) C1449065) IKBE;
IKB-Epsilon;
NF-Kappa B Inhibitor Epsilon;
NF-Kappa-B IE;
NFKBIE;
Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor Epsilon =Amino Acid, Peptide, or Protein; Biologically Active Substance

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