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1. I 131 Liothyronine
[A radioconjugate of synthetic active thyroid hormone, liothyronine (T3), labeled with Iodine 131. Liothyronine involves many important metabolism and is essential to proper development and differentiation of all cells. I131 liothyronine may be used in radiotherapy in thyroid cancers. ( NCI )] (UMLS (NCI) C0338103) =Organic Chemical; Indicator, Reagent, or Diagnostic Aid
51. IL11
[This gene plays a role in the regulation of cell proliferation and differentiation. ( NCI )] (UMLS (NCI) C1334100) IL11 Gene;
Interleukin 11 Gene =Gene or Genome
2. IL
[A state in the central midwest United States. Its capital is Springfield. ( NCI )] (UMLS (NCI) C0020898) =Geographic Area ;
◊ [Middle Eastern country bordering on the Mediterranean, republic established 1948, capital city is Jerusalem. ( CSP )] (UMLS (NCI) C0022271) Geographic Area ; Middle East;
52. IL11RA
[This gene is involved in interleukin 11 receptor mediation and signal transduction. ( NCI )] (UMLS (NCI) C1334099) IL11RA Gene;
Interleukin 11 Receptor, Alpha Gene =Gene or Genome ◊ [This protein is the alpha subunit of the high-affinity receptor for interleukin-11. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. (LocusLink) ( NCI )] (UMLS (NCI) C1334200) Interleukin 11 Receptor Alpha; Amino Acid, Peptide, or Protein; Receptor ;
3. IL-10C
[Interleukin-19, encoded by the IL19 gene, is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. (From LocusLink) ( NCI )] (UMLS (NCI) C0964553) IL19;
IL19 Protein;
Interleukin 19;
Interleukin 19 Precursor;
Interleukin-19 Precursor;
Melanoma Differentiation Associated Protein-Like Protein;
ZMDA1 =Amino Acid, Peptide, or Protein; Immunologic Factor ;
53. IL12A
[This gene plays a role in immunity/defense via the stimulation of both T cells and natural killer cells. It is also involved in cell differentiation. ( NCI )] (UMLS (NCI) C1334101) IL12A Gene;
Interleukin 12A (Natural Killer Cell Stimulatory Factor 1, Cytotoxic Lymphocyte Maturation Factor 1, P35) Gene =Gene or Genome
4. IL-12 gene
[The DNA sequence that encodes the protein cytokine interleukin-12 (IL-12). When introduced as the complementary DNA (cDNA) form into tumor cells by, for example, a genetically engineered adenovirus vector, the transfected IL-12 cDNA expresses IL-12 which activates antitumoral natural killer (NK) cells and CD8+ T-cells and stimulates the secretion of interferon-gamma (IFN-gamma), potentially inhibiting tumor cell metastasis. This gene therapy may also result in IL-12-mediated inhibition of vascular endothelial growth factor (VEGF) and enhancement of matrix metalloproteinases (MMPs). (NCI04) ( NCI )] (UMLS (NCI) C0879338) Interleukin-12 Gene;
Plasmid DNA Encoding Human Interleukin-12;
Plasmid IL-12;
=Gene or Genome
54. IL12B
[This gene is involved in immunity/defense via the stimulation of both T cells and natural killer cells. It also plays a role in cell differentiation. ( NCI )] (UMLS (NCI) C1334102) IL12B Gene;
Interleukin 12B (Natural Killer Cell Stimulatory Factor 2, Cytotoxic Lymphocyte Maturation Factor 2, P40) Gene =Gene or Genome
5. IL-1A/IL-2
(UMLS (NCI) C0281139) =Therapeutic or Preventive Procedure
55. IL12RB1
[This gene plays a role in cellular signaling and is involved in immunity/defense. ( NCI )] (UMLS (NCI) C1416383) IL12RB1 Gene;
Interleukin 12 Receptor, Beta 1 Gene =Gene or Genome
6. IL-1A/indomethacin
(UMLS (NCI) C0279092) =Therapeutic or Preventive Procedure
56. IL12RB2
[This gene is involved in cellular signaling. It is also involved in the immune response and host defense in Leprosy. ( NCI )] (UMLS (NCI) C1416384) IL12RB2 Gene;
Interleukin 12 Receptor, Beta 2 Gene;
=Gene or Genome
7. IL-1A/Indomethacin/VP-16
(UMLS (NCI) C0281172) =Therapeutic or Preventive Procedure ;
57. IL13
[T lymphocyte derived cytokine that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B lymphocytes; it appears to play a role in regulating inflammatory and immune responses. ( CSP )] (UMLS (NCI) C0214743) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
8. IL-1A/MTX
(UMLS (NCI) C0281540) =Therapeutic or Preventive Procedure
58. IL13
[This gene is involved in inflammatory processes and has been identified as a therapeutic target in persons with asthma. ( NCI )] (UMLS (NCI) C1334103) IL13 Gene;
Interleukin 13 Gene =Gene or Genome
9. IL-1B/IL-2
(UMLS (NCI) C0281166) =Therapeutic or Preventive Procedure ;
59. IL13RA1
[This gene plays a role in the modulation of cellular proliferation and signal transduction. ( NCI )] (UMLS (NCI) C1416385) IL13RA1 Gene;
Interleukin 13 Receptor, Alpha 1 Gene;
=Gene or Genome
10. IL-2/IL-4
(UMLS (NCI) C0279200) =Therapeutic or Preventive Procedure
60. IL15
[cytokine that stimulates the proliferation of T lymphocytes and shares biological activities with interleukin 2; it also can induce B lymphocyte proliferation and differentiation. ( CSP )] (UMLS (NCI) C0254610) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
11. IL-2/IL-4/TIL
(UMLS (NCI) C0281236) =Therapeutic or Preventive Procedure ;
61. IL15
[This gene is involved in the regulation of memory T cells and cytokine production. ( NCI )] (UMLS (NCI) C1334105) IL15 Gene;
Interleukin 15 Gene;
=Gene or Genome
12. IL-2/IL-6
(UMLS (NCI) C0281029) =Therapeutic or Preventive Procedure
62. IL16
[Interleukin-16, encoded by the IL16 gene, is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. As a ligand for CD4, the signaling process of this cytokine is mediated by CD4. It stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils as well as induces T-lymphocyte expression of interleukin 2 receptor. The product of this gene undergoes proteolytic processing, which yields two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is involved in the proteolytic processing of this protein. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. (From LocusLink, Swiss-Prot and NCI) ( NCI )] (UMLS (NCI) C0065337) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
13. IL-2/Indomethacin/LAK
(UMLS (NCI) C0281495) =Therapeutic or Preventive Procedure
63. IL16
[This gene is involved in chemotaxis and is a pro-inflammatory factor. ( NCI )] (UMLS (NCI) C1334106) IL16 Gene;
Interleukin 16 (Lymphocyte Chemoattractant Factor) Gene;
=Gene or Genome
14. IL-2/LAK/MOAB R24
(UMLS (NCI) C0280737) =Therapeutic or Preventive Procedure ;
64. IL17C
[This gene plays a role in inflammatory processes and modulates cytokine activity. ( NCI )] (UMLS (NCI) C1334107) IL17C Gene;
Interleukin 17C Gene;
=Gene or Genome
15. IL-2/LEV
(UMLS (NCI) C0281000) =Therapeutic or Preventive Procedure
65. IL18
[This gene is involved in the induction and regulation of pro-inflammatory cytokines. ( NCI )] (UMLS (NCI) C1334109) IL18 Gene;
Interleukin 18 (Interferon-Gamma-Inducing Factor) Gene;
=Gene or Genome
16. IL-2/M-CSF
(UMLS (NCI) C0281350) =Therapeutic or Preventive Procedure
66. IL19
[This gene is involved in the induction and regulation of inflammatory cytokines. ( NCI )] (UMLS (NCI) C1334110) IL19 Gene;
Interleukin 19 Gene;
=Gene or Genome
17. IL-2/MART-1
(UMLS (NCI) C0281721) =Therapeutic or Preventive Procedure
67. IL1A
[This gene plays a role in the mediation of inflammation and immunity. ( NCI )] (UMLS (NCI) C1334111) IL1A Gene;
Interleukin 1, Alpha Gene;
=Gene or Genome
18. IL-2/MLT
(UMLS (NCI) C0338262) =Therapeutic or Preventive Procedure
68. IL1B
[This gene is involved in the mediation of acute phase inflammatory responses. ( NCI )] (UMLS (NCI) C1334112) IL1B Gene;
Interleukin 1, Beta Gene;
=Gene or Genome
19. IL-2/MOAB 14G2A
(UMLS (NCI) C0280841) =Therapeutic or Preventive Procedure
69. IL1R1
[This gene is involved in a variety of cytokine induced immune and inflammatory responses. ( NCI )] (UMLS (NCI) C1416395) IL1R1 Gene;
Interleukin 1 Receptor, Type I Gene;
=Gene or Genome
20. IL-2/MOAB 3622W94
(UMLS (NCI) C0677998) =Therapeutic or Preventive Procedure
70. IL1R2
[This gene plays a role in the modulation of ligand interactions and cytokine regulation. ( NCI )] (UMLS (NCI) C1416396) IL1R2 Gene;
Interleukin 1 Receptor, Type II Gene;
=Gene or Genome
21. IL-2/MOAB Ch14.18/MOAB R24
(UMLS (NCI) C0281691) =Therapeutic or Preventive Procedure
71. IL2
[This gene is involved in growth and lymphokine regulation. ( NCI )] (UMLS (NCI) C0879590) IL2 Gene;
IL-2 Gene;
Interleukin 2 Gene;
Interleukin-2 Gene =Gene or Genome
22. IL-2/MOAB HuM195
(UMLS (NCI) C0281728) =Therapeutic or Preventive Procedure
72. IL2-Inducible T-Cell Kinase Gene
[This gene is involved in the differentiation and proliferation of T cells. ( NCI )] (UMLS (NCI) C1367389) ITK;
ITK Gene =Gene or Genome
(UMLS (NCI) C0678099) =Therapeutic or Preventive Procedure
73. IL2/LAK
(UMLS (NCI) C0280508) =Therapeutic or Preventive Procedure ;
24. IL-2/MOAB Lym-1
(UMLS (NCI) C0280732) =Therapeutic or Preventive Procedure ;
74. IL23A
[This gene plays a role in transcriptional regulation and in the production of interferon-gamma. ( NCI )] (UMLS (NCI) C1423526) IL23A Gene;
Interleukin 23, Alpha Subunit p19 Gene =Gene or Genome
25. IL-2/MOAB OKT3
(UMLS (NCI) C0338198) =Therapeutic or Preventive Procedure ;
75. IL24
[Encoded by human IL24 Gene, secreted Interleukin 24 Protein (IL10 Family) consists of 206 amino acids with a predicted size of 23.8 kD (precursor). IL24 appears to represent a differentiation-, growth-, and apoptosis-associated protein. It is growth inhibitory toward diverse tumor cells and may contribute to terminal cell differentiation. The protein selectively induces p53-independent apoptosis in breast carcinoma cells and inhibits tumor growth in nude mice. IL24 is a negative regulator of progression in human melanoma cells induced to terminally differentiate. (from SWISS-PROT, OMIM, and NCI) ( NCI )] (UMLS (NCI) C0385569) =Amino Acid, Peptide, or Protein; Pharmacologic Substance ;
(UMLS (NCI) C0338201) =Therapeutic or Preventive Procedure
76. IL24
[This gene is involved in cellular growth, differentiation, and apoptosis. ( NCI )] (UMLS (NCI) C1366521) IL24 Gene;
Interleukin 24 Gene =Gene or Genome
(UMLS (NCI) C0338199) =Therapeutic or Preventive Procedure ;
77. IL27RA
[This gene is involved in cell-mediated immunity and differentiation. ( NCI )] (UMLS (NCI) C1424880) IL27RA Gene;
Interleukin 27 Receptor, Alpha Gene =Gene or Genome
28. IL-2/MOAB R24
(UMLS (NCI) C0280888) =Therapeutic or Preventive Procedure
78. IL2RA
[This gene plays a role in clathrin-independent endocytosis and immune functions. ( NCI )] (UMLS (NCI) C1334114) IL2RA Gene;
Interleukin 2 Receptor, Alpha Gene;
=Gene or Genome
29. IL-2/NMA
(UMLS (NCI) C0281762) =Therapeutic or Preventive Procedure
79. IL2RB
[This gene is involved in the regulation of myeloid cell development. ( NCI )] (UMLS (NCI) C1334115) IL2RB Gene;
Interleukin 2 Receptor, Beta Gene;
=Gene or Genome
30. IL-2/PEG-IL-2
(UMLS (NCI) C0280911) =Therapeutic or Preventive Procedure
80. IL2RG
[This gene plays a role in immune function and mediates T-cell responses. ( NCI )] (UMLS (NCI) C1334116) IL2RG Gene;
Interleukin 2 Receptor, Gamma (Severe Combined Immunodeficiency) Gene;
=Gene or Genome
31. IL-2/Poly ICLC
(UMLS (NCI) C0278658) =Therapeutic or Preventive Procedure
81. IL3
[This gene plays a role in hematopoiesis and has neurotrophic activity. ( NCI )] (UMLS (NCI) C1334117) IL3 Gene;
Interleukin 3 (Colony-Stimulating Factor, Multiple) Gene;
=Gene or Genome
32. IL-2/ras pep vac
(UMLS (NCI) C0796495) Interleukin-2/Ras Peptide Cancer Vaccine;
=Therapeutic or Preventive Procedure ;
82. IL3RA
[This gene is involved in signal transduction and several diverse biological processes. ( NCI )] (UMLS (NCI) C1416408) IL3RA Gene;
Interleukin 3 Receptor, Alpha (Low Affinity) Gene;
=Gene or Genome
33. IL-2/TIL
(UMLS (NCI) C0280618) =Therapeutic or Preventive Procedure
83. IL4
[This gene is involved in the regulation of the proliferation and differentiation of B-cells. ( NCI )] (UMLS (NCI) C1334119) IL4 Gene;
Interleukin 4 Gene;
=Gene or Genome
34. IL-2/TNF
(UMLS (NCI) C0280613) =Therapeutic or Preventive Procedure
84. IL4R
[This gene plays a prominent role in immunoglobulin E production and cellular signal transduction. ( NCI )] (UMLS (NCI) C1334118) IL4R Gene;
Interleukin 4 Receptor Gene;
=Gene or Genome
35. IL-2/TNFR:Fc
(UMLS (NCI) C0281501) =Therapeutic or Preventive Procedure
85. IL5
[This gene plays a role in eosinophil differentiation. ( NCI )] (UMLS (NCI) C1334121) IL5 Gene;
Interleukin 5 (Colony-Stimulating Factor, Eosinophil) Gene =Gene or Genome
36. IL-2/TSPA
(UMLS (NCI) C0279274) =Therapeutic or Preventive Procedure ;
86. IL5RA
[This gene plays a role in interleukin 5 regulation and receptor signal transduction. ( NCI )] (UMLS (NCI) C1334120) IL5RA Gene;
Interleukin 5 Receptor, Alpha Gene;
=Gene or Genome
37. IL-2/VBL
(UMLS (NCI) C0281738) =Therapeutic or Preventive Procedure
87. IL6
[This gene is involved in immunoregulation processes by activating a cell-surface signaling assembly of proteins. ( NCI )] (UMLS (NCI) C1334122) IL6 Gene;
Interleukin 6 (Interferon, Beta 2) Gene =Gene or Genome
38. IL-2/ZDV
(UMLS (NCI) C0278673) =Therapeutic or Preventive Procedure
88. IL6R Gene
[This gene in involved in the regulation of cellular responses; such as the immune response, hematopoiesis, and acute-phase inflammatory reactions. ( NCI )] (UMLS (NCI) C1416409) IL6R1;
Interleukin 6 Receptor Gene;
=Gene or Genome
39. IL-2/ZnO
(UMLS (NCI) C0338215) =Therapeutic or Preventive Procedure
89. IL6ST
[This gene plays a role in signal transduction and is putatively involved in embryonic development. ( NCI )] (UMLS (NCI) C1325331) IL6ST Gene;
Interleukin 6 Signal Transducer (GP130, Oncostatin M Receptor) Gene =Gene or Genome ;
40. IL-3 Receptor
[Heterodimeric human Interleukin 3 Receptor is composed of 378-aa 43-kDa (precursor) Interleukin 3 Receptor Alpha and GM-CSF/IL-3/IL-5 Receptor Common Beta-Chain. IL3RA is a type I membrane protein with a box 1 motif for JAK interaction/activation and a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding. Receptor binding to IL3 depends on the signal transducing beta subunit, common to the high affinity IL3-, IL5- and GM-CSF receptors. (NCI) ( NCI )] (UMLS (NCI) C0080096) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor ;
90. IL7
[produced by epithelial and mesangial stromal cells; serves as a differentiation factor for B cell early development; also supports growth of some thymocytes and T lymphocytes. ( CSP )] (UMLS (NCI) C0021761) =Amino Acid, Peptide, or Protein; Immunologic Factor =Cytokine;
hematopoietic growth factor
41. IL-3/IL-6
(UMLS (NCI) C0281445) =Therapeutic or Preventive Procedure
91. IL7
[This gene is involved in regulating immune responses in the intestinal mucosa. ( NCI )] (UMLS (NCI) C1334124) IL7 Gene;
Interleukin 7 Gene =Gene or Genome
42. IL-3/L-PAM
(UMLS (NCI) C0281245) =Therapeutic or Preventive Procedure ;
92. IL7R
[This gene is involved in the regulation of lymphopoiesis. ( NCI )] (UMLS (NCI) C1334123) IL7R Gene;
Interleukin 7 Receptor Gene =Gene or Genome
43. IL-3/TSPA
(UMLS (NCI) C0281196) =Therapeutic or Preventive Procedure
93. IL8
[This gene plays a role in the mediation of inflammatory responses and in angiogenesis. ( NCI )] (UMLS (NCI) C1366571) IL8 Gene;
Interleukin 8 Gene =Gene or Genome
44. IL-3/ZDV
(UMLS (NCI) C0281252) =Therapeutic or Preventive Procedure ;
94. IL8RA
[This gene is involved in pro-inflammatory cytokine cellular responses and neutrophil activation. ( NCI )] (UMLS (NCI) C1334125) IL8RA Gene;
Interleukin 8 Receptor, Alpha Gene =Gene or Genome
45. IL-4 Fusion Toxin
[A substance that is being studied as an anticancer drug. It belongs to the family of drugs called recombinant chimeric proteins. Also called NBI-3001. ( NCI )] (UMLS (NCI) C1313726) IL-4 PE38KDEL Immunotoxin;
Interleukin-4 Fusion Toxin;
interleukin-4 PE38KDEL cytotoxin;
interleukin-4 pe38kdel immunotoxin;
Interleukin-4 Pseudomonas Exotoxin;
=Amino Acid, Peptide, or Protein; Pharmacologic Substance; Immunologic Factor
95. IL8RB
[This gene is involved in pro-inflammatory cytokine cellular responses, neutrophil activation, and chemotaxis. ( NCI )] (UMLS (NCI) C1334126) IL8RB Gene;
Interleukin 8 Receptor, Beta wt Allele =Gene or Genome
46. IL1
[macrophage produced interleukin that induces the production of interleukin 2 by T cells that have been stimulated by antigen or mitogen; at least two types, alpha and beta, exist; interleukin 1 or a similar protein is also produced by epithelial cells and stimulates fibroblast proliferation and release of proteolytic enzymes and prostaglandins in inflammatory processes. ( CSP )] (UMLS (NCI) C0021755) =Amino Acid, Peptide, or Protein; Immunologic Factor =Cytokine;
hematopoietic growth factor
96. IL9
[This gene plays a role in inflammatory processes and has been implicated in the pathogenesis of asthma. ( NCI )] (UMLS (NCI) C1334127) IL9 Gene;
Interleukin 9 Gene =Gene or Genome
47. IL1 convertase enzyme
[ ] (UMLS (CSP) C0543491) =Amino Acid, Peptide, or Protein; Enzyme
97. Ilarvirus
[A genus of the family BROMOVIRIDAE which infects mainly woody plants. Species are divided into ten subgroups. Tobacco streak virus is the type species. ( MSH )] (UMLS (CSP) C0376456) =Virus
48. IL10
[This gene plays an anti-inflammatory role in immune processes and is involved in a variety of diseases. ( NCI )] (UMLS (NCI) C1334098) IL10 Gene;
Interleukin 10 Gene =Gene or Genome
98. ILD
[heterogeneous group of noninfectious, nonmalignant disorders of the lower respiratory tract, affecting primarily the alveolar wall structures but also often involving the small airways and blood vessels of the lung parenchyma; may lead to respiratory insufficiency and death. ( CSP )] (UMLS (CSP) C0206062) =Disease or Syndrome ;
=Lung Diseases;
pulmonary fibrosis/granuloma;
histiocytosis X;
pulmonary fibrosis;
Lung Sarcoidosis;
Wegener's granulomatosis;
radiation fibrosis;
Anti-Glomerular Basement Membrane Disease
49. IL10RB
[This protein belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. ( NCI )] (UMLS (NCI) C0217502) =Amino Acid, Peptide, or Protein; Receptor ;
99. Ileal Conduit
(UMLS (HL7) C0441253) =Acquired Abnormality =Body Part;
50. IL10RB
[This gene plays a role in cytokine regulation and signal transduction. ( NCI )] (UMLS (NCI) C1334097) IL10RB Gene;
Interleukin 10 Receptor, Beta Gene =Gene or Genome
(UMLS (ICD9CM) C0846489) =Diagnostic Procedure

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