- 1. 5'-Inosinic Acid, Homopolymer Complex with 5'-Cytidylic Acid Homopolymer
- [interferon inducer consisting of a synthetic, mismatched double-stranded RNA; the polymer is made of one strand each of polyinosinic acid and polycytidylic acid. ( CSP )] (UMLS (NCI) C0032414) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance =interferon inducer;
polynucleotide | - 9. Inosine Mono[4-(acetylamino)benzoate] Salt Compd with 1-(dimethylamino)-2-propanol(1:3)
- [An alkylamino-alcohol complex of inosine used in the treatment of a variety of viral infections. Unlike other antiviral agents, it acts by modifying or stimulating cell-mediated immune processes rather than acting on the virus directly. ( MSH )] (UMLS (NCI) C0022230) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
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- 2. INO-1001
- [A isoindolinone derivative and potent inhibitor of the nuclear enzyme poly (ADP-ribose) polymerase (PARP) with chemosensitization and radiosensitization properties. INO-1001 inhibits PARP, which may result in inhibition of tumor cell DNA repair mechanisms and, so, tumor cell resistance to chemotherapy and radiation therapy. PARP enzymes are activated by DNA breaks and have been implicated in the repair of DNA single-strand breaks (SSB). ( NCI )] (UMLS (NCI) C1504945) =Organic Chemical; Pharmacologic Substance ;
| - 10. Inositol 1,4,5-Triphosphate Receptor Type 1
- [Widely expressed by human ITPR1 Gene (InsP3R Family) as 8 potential alternative isoforms, 2758-aa 314-kDa integral endoplasmic reticulum membrane protein Inositol 1,4,5-Triphosphate Receptor Type 1 mediates release of intracellular calcium in response to second messenger inositol 1,4,5-trisphosphate. A likely homotetramer, the receptor contains 5 MIR domains, a large N-terminal ligand-binding cytoplasmic region, and central modulatory sites immediately upstream of the C-terminal calcium channel. Calcium appears to inhibit ligand binding to the receptor, perhaps by interaction with an inhibitory calcium-binding protein. Phosphorylation may prevent ligand-induced opening of the calcium channel. ITPR1 interacts with TRPC4 and is phosphorylated by c-AMP kinase. (NCI) ( NCI )] (UMLS (NCI) C0626645) =Amino Acid, Peptide, or Protein; Receptor ;
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- 3. Inomax
- (UMLS (NCI) C1330345) =Pharmacologic Substance; Inorganic Chemical ;
| - 11. Inositol 1,4,5-Triphosphate Receptor, Type 1 Gene
- [This gene plays a role in intracellular calcium level regulation in cells. ( NCI )] (UMLS (NCI) C1334148) ITPR1;
ITPR1 Gene;
=Gene or Genome ;
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- 4. Inoperable
- [Not suitable for surgery. ( NCI )] (UMLS (NCI) C0205187) =Qualitative Concept
| - 12. Inositol 1,4,5-triphosphate-associated cGMP Kinase Substrate
- [The gene encoding this protein is similar to a mouse putative tumor suppressor gene that is frequently disrupted by mouse AIDS-related virus (MRV). The protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is downregulated during myeloid differentiation. Therefore, this gene may be a myeloid leukemia tumor suppressor gene. This protein is an inositol 1,4,5-triphosphate-associated cGMP kinase substrate. Calcium release from the endoplasmic reticulum controls a number of cellular processes, including proliferation and contraction of smooth muscle and other cells and contributes to the antiproliferative and proapoptotic effects of nitric oxide and cGMP. (from LocusLink and OMIM) ( NCI )] (UMLS (NCI) C0767190) JAW1-Related Protein;
MRVI1;
=Amino Acid, Peptide, or Protein; Biologically Active Substance ;
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- 5. INORG DUST PNEUMOCON NEC
- (UMLS (ICD9CM) C0032274) =Disease or Syndrome
| - 13. Inositol 1,4,5-Trisphosphate
- [Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin. ( MSH )] (UMLS (NCI) C0021549) =Carbohydrate; Biologically Active Substance ;
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- 6. Inorganic Chemical
- [A broad class of substances, principally from mineral sources of non-biological origin, encompassing all those that do not include carbon and its derivatives as their principal elements. ( NCI )] (UMLS (NCI) C0021521) =Inorganic Chemical =active ingredient;
=acid;
Alkalies;
Arsenic Compound;
Boron Compounds;
electrolyte;
Element;
Gas;
metal;
Mineral;
Nitrogen Compounds;
sulfur compound;
Technetium Compounds;
Aluminum Compounds;
Chromium Compounds;
Barium Compounds;
Calcium Compounds;
Fluorine Compounds;
Iodine Compounds;
Iron Compounds;
Magnesium Compounds;
Silicon Compounds;
Mercury Compounds;
Sodium Compounds;
Platinum Agents;
Potassium Compounds;
Manganese Compounds;
Zinc Compounds;
Tin Compounds;
Lithium Compounds;
Silver Compounds;
Selenium Compound;
Phosphorus Compounds;
Carbon Compounds, Inorganic;
Oxygen Compounds;
Chlorine Compounds | - 14. Inositol Metabolism
- [The chemical reactions and pathways involving myo-inositol, 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms. [ISBN:0198547684] ( GO )] (UMLS (NCI) C1156470) Inositol Metabolism Pathway;
=Molecular Function |
- 7. Inorganic Chemistry
- [A field of chemistry which pertains to chemical compounds or ions that do not contain the element carbon (with the exception of carbon dioxide and compounds containing a carbonate radical, e.g., calcium carbonate). ( MSH )] (UMLS (NCI) C0008001) =Occupation or Discipline ;
| - 15. inositol phosphate
- [phosphoric acid esters of inositol. ( CSP )] (UMLS (CSP) C0021554) =Carbohydrate =cis-1,2,3,5-trans-4,6-Cyclohexanehexol;
sugar phosphate =Phytic Acid |
- 8. inosine
- [purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose; an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage; also occurs in the anticodon of certain transfer RNA molecules. ( CSP )] (UMLS (CSP) C0021528) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance; Biologically Active Substance =purine nucleoside;
ribonucleoside =2',3'-Dideoxyinosine | - 16. Inoviridae
- [A family of rod-shaped or filamentous bacteriophages consisting of single-stranded DNA. There are two genera: INOVIRUS and PLECTROVIRUS. ( MSH )] (UMLS (CSP) C0206393) =Virus
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