- 1. MPZL1
- [This gene plays a role in cell migration. ( NCI )] (UMLS (NCI) C1334528) MPZL1 Gene;
Myelin Protein Zero-Like 1 Gene =Gene or Genome ;
◊ [Widely expressed (highest in heart, placenta, kidney, and pancreas) by human MPZL1 Gene (Ig Superfamily), 269-aa 43-kD hyperphosphorylated cell surface membrane glycoprotein Myelin Protein Zero-Like 1 Protein contains an N-terminal signal sequence, an extracellular Ig-like domain with potential N-linked glycosylation sites, a single membrane-spanning segment, and an intracellular pair of consensus immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Specifically binding through its ITIMs to tyrosine phosphatase PTPN11, a positive transducer of growth factor signal transduction, MPZL1 is dephosphorylated by PTPN11, but not by PTPN6, which has a negative role in hematopoietic cell proliferation. Having 45.8% identity with Myelin Protein Zero, MPZL1 may have a role in cell signaling via c-Src. (NCI) ( NCI )] (UMLS (NCI) C1334837) Myelin Protein Zero-Like 1; Protein Zero-Related; PZR; Amino Acid, Peptide, or Protein; Biologically Active Substance | |
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