- 1. (+/-)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide
- [An anticancer drug that belongs to the family of drugs called antiandrogens. ( NCI )] (UMLS (NCI) C0285590) =Organic Chemical; Pharmacologic Substance ;
=Anilides;
[AN000] ANTINEOPLASTICS =BICALUTAMIDE 50 MG | - 2. N-[1-(2-Cyano-2-deoxy-beta-D-arabinofuranosyl]-2-oxo-1,2-dihydropyrimidin-4-yl}hexadecanamide
- [An orally bioavailable pyrimidine analog with potential antineoplastic activity. Sapacitabine is hydrolyzed by amidases to the deoxycytosine analog CNDAC (2'-Cyano-2'-deoxyarabinofuranosylcytosine), which is then phosphorylated into its active triphosphate form. As an analog of deoxycytidine triphosphate, CNDAC triphosphate molecules get incorporated into DNA strands during replication, thereby leading to single-stranded DNA breaks caused by beta-elimination in fidelity check point. As a result, this agent induces cell cycle arrest in the G2 phase and subsequently triggers apoptosis. ( NCI )] (UMLS (NCI) C0764827) Sapacitabine;
=Organic Chemical |
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