- 1. 13-(N,N-Dimethylglycyl)brefeldin A
- [A water soluble analogue of the antineoplastic agent brefeldin A (BFA). (NCI04) ( NCI )] (UMLS (NCI) C0760968) Breflate =Organic Chemical; Pharmacologic Substance ;
| - 5. N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide
- [A nonsteroidal arylsulfonamide with anti-inflammatory properties. Nimesulide inhibits the cyclooxygenase-mediated conversion of arachidonic acid to pro-inflammatory prostaglandins. Modestly selective for COX-2, this agent binds to the enzyme, thereby inactivating it. Nimesulide may inhibit some carcinogenic COX-2-related carcinogenic effects on xenobiotic metabolism, apoptosis, immune surveillance and angiogenesis (overexpressed COX-2 in tumor epithelial cells enhances production of vascular growth factors and the formation of capillary-like networks). (NCI04) ( NCI )] (UMLS (NCI) C0132515) =Organic Chemical; Pharmacologic Substance ;
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- 2. N,N,N',N',N"-pentamethyl-1,3,5-triazine
- [A principal metabolite of hexamethylmelamine with antineoplastic activity. Pentamethylmelamine alkylates DNA and other macromolecules and forms DNA intrastrand and DNA-protein crosslinks, thereby preventing DNA replication. (NCI04) ( NCI )] (UMLS (NCI) C0070302) =Organic Chemical; Pharmacologic Substance ;
| - 6. N-(5-[N-(3,4-Dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl)-L-glutamic Acid
- [An anticancer drug that inhibits tumor cells from multiplying by interfering with cells' ability to make DNA. ( NCI )] (UMLS (NCI) C0677667) =Organic Chemical; Pharmacologic Substance
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- 3. N,N-bis(carboxymethoxy)glycine
- [A white, crystalline solid compound. Nitrilotriacetic acid is mainly used as a chelating and eluting agent and is found in laundry detergents. Exposure to Nitrilotriacetic acid irritates the skin, eyes and respiratory tract and causes kidney and bladder damage. Nitrilotriacetic acid is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0028132) =Organic Chemical; Indicator, Reagent, or Diagnostic Aid
| - 7. N-(N-(N-(N(2)-L-Arginyl-L-Lysyl)-L-alpha-Aspartyl)-L-Valyl)-L-Tyrosine
- [A synthetic pentapeptide which is the active site of the naturally occurring hormone thymopoietin with immunomodulating properties. Thymopentin enhances the production of thymic T cells and may help restore immunocompetence in immunosuppressed subjects. This agent also augments the effects of ionizing radiation by arresting cancer cells in the G2/M phase of the cell cycle. (NCI04) ( NCI )] (UMLS (NCI) C0080225) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Biologically Active Substance
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- 4. N,N-Dibenzyl Daunomycin
- [The N-alkylated analogue of the anthracycline antineoplastic antibiotic daunomycin. N,N-Dibenzyl Daunomycin interacts with topoisomerase II, thereby inhibiting DNA replication and repair and promoting DNA fragmentation. This agent is less cardiotoxic than daunomycin. (NCI04) ( NCI )] (UMLS (NCI) C0067345) =Organic Chemical; Pharmacologic Substance
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