[A broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with antibacterial property. Sulfamethizole competes with PABA for the bacterial enzyme dihydropteroate synthase, thereby preventing the incorporation of PABA into dihydrofolic acid, the immediate precursor of folic acid. This leads to an inhibition of bacterial folic acid synthesis and de novo synthesis of purines and pyrimidines, ultimately resulting in cell growth arrest and cell death. ( NCI )] (UMLS (NCI) C0038687) =Organic Chemical; Pharmacologic Substance =Sulfathiazoles; [AM650] SULFONAMIDE/RELATED ANTIMICROBIALS =SULFAMETHIZOLE 250 MG; SULFAMETHIZOLE 500 MG; SULFAMETHIZOLE 0.5 GM; SULFAMETHIZOLE 400 MG; SULFAMETHIZOLE 800 MG;