- 1. 2PP2A
- [Expressed by human SET Gene (NAP Family) in all tissues and responsive to serum factors, contact inhibition, or differentiation, 277-aa 32-kDa nuclear Phosphatase 2A Inhibitor I2PP2A is a specific inhibitor of PP2A that may be involved in intracellular signaling after ligand activation of HLA class II molecules. Serine phosphorylated SET has a long acidic C-terminus and SET domain. Located in an ER-associated complex containing pp32, HMG2, and APE1, SET is a specific inhibitor of GZMA-activated DNase/nucleoside diphosphate kinase (GAAD/NM23H1), which mediates GZMA-induced caspase-independent apoptosis characterized by single-stranded DNA nicks. GZMA cleavage of SET releases NM23H1 from bound inhibition to SET and results in SET degradation, NM23H1 translocation to the nucleus, and NM23H1 nicking of DNA. (NCI) ( NCI )] (UMLS (NCI) C1137947) HLA-DR Associated Protein II;
I2PP2A;
IGAAD;
Inhibitor of GZMA-Activated DNase;
PHAPII;
Phosphatase 2A Inhibitor I2PP2A;
SET;
SET Protein;
SET Translocation Inhibitor-2 of Protein Phosphatase-2A;
TAF-IBeta;
Template Activating Factor I Beta =Amino Acid, Peptide, or Protein; Biologically Active Substance | - 6. PP2A Subunit A PR65-Beta
- [Encoded by human PPP2R1B Gene (PP2A Subunit A Family), 601-aa 66-kDa Protein Phosphatase 2 Regulatory Subunit A Beta contains 15 HEAT repeats that form a rod-like structure consisting of alpha helices joined by a hydrophilic loop. PPP2R1B is a constant regulatory/scaffolding subunit of PP2 that coordinates assembly of the phosphatase catalytic subunit and various regulatory subunits or cell signaling molecules. A major Ser/Thr phosphatase in cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. PPP2R1B interacts with IPO9. (NCI) ( NCI )] (UMLS (NCI) C1448071) PP2A Subunit A R1-Beta;
PPP2R1B;
Protein Phosphatase 2 Regulatory Subunit A Beta;
Protein Phosphatase 2 Structural/Regulatory Subunit A Beta;
Serine/Threonine Protein Phosphatase 2A 65 kDa Regulatory Subunit A Beta;
=Amino Acid, Peptide, or Protein; Biologically Active Substance ;
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- 2. PP2A B Subunit B Prime Alpha
- [Ubiquitously expressed (heart and skeletal muscle highest) by human PPP2R5A Gene (PP2A Subunit B Family), serine phosphorylated 486-aa 56-kDa cytoplasmic Protein Phosphatase 2 Regulatory Subunit B Alpha is a subunit of PP2A. A major Ser/Thr phosphatase implicated in negative control of cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Combinations of different subunit isoforms can generate many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. (NCI) ( NCI )] (UMLS (NCI) C1335542) PP2A B Subunit B56 Alpha;
PP2A B Subunit PR61 Alpha;
PP2A B Subunit R5 Alpha;
PPP2R5A;
Protein Phosphatase 2 Regulatory Subunit B Alpha;
Protein Phosphatase 2A Regulatory Subunit B56 Alpha;
Serine/Threonine Protein Phosphatase 2A 56 kDa Regulatory Subunit Alpha;
=Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 7. PP2A-Alpha
- [Encoded by human PPP2CA Gene (PP1 Family), 309-aa 36-kDa cytoplasmic Protein Phosphatase 2 Catalytic Subunit Alpha forms alpha complexes with a structural PR65/A subunit and beta complexes with an alpha4 protein; association with a regulatory subunit that controls substrate selectivity and activity forms as a specific trimeric holoenzyme. PPP2CA is regulated by inactivating threonine or tyrosine phosphorylation, carboxy methylation, ceramide, and protein inhibitors. Carboxyl methylation may play a role in holoenzyme assembly; it varies during the cell cycle. PP2A can dephosphorylate p53, and modulate phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP2 kinase activity. Core PP2A enzyme consists of the catalytic subunit and a common 65-kDa regulatory subunit; additional regulatory subunits or signaling molecules further modify function. (NCI) ( NCI )] (UMLS (NCI) C1335539) PP2CA;
PPP2CA;
Protein Phosphatase 2 Catalytic Subunit Alpha;
Replication Protein C;
RP-C;
Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Alpha =Amino Acid, Peptide, or Protein; Enzyme ;
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- 3. PP2A B Subunit B Prime Beta
- [Ubiquitously expressed (highest in brain) as 2 isoforms by human PPP2R5B Gene (PP2A Subunit B Family), serine phosphorylated cytoplasmic Protein Phosphatase 2 Regulatory Subunit B Beta is a regulatory subunit of PP2A. A major Ser/Thr phosphatase implicated in negative control of cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Combinations of different subunit isoforms can generate many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. (NCI) ( NCI )] (UMLS (NCI) C1335543) PP2A B Subunit B56 Beta;
PP2A B Subunit PR61 Beta;
PP2A B Subunit R5 Beta;
PPP2R5B;
Protein Phosphatase 2 Regulatory Subunit B Beta;
Protein Phosphatase 2A Regulatory Subunit B56 Beta;
Serine/Threonine Protein Phosphatase 2A 56 kDa Regulatory Subunit Beta;
=Amino Acid, Peptide, or Protein; Enzyme ;
| - 8. PP2A-Beta
- [Encoded by human PPP2CB Gene (PP1 Family), ubiquitous 309-aa 36-kDa cytoplasmic serine/threonine-specific Protein Phosphatase 2 Catalytic Subunit Beta forms a core complex with a PR65/A subunit; association with additional regulatory subunits that control substrate selectivity/activity forms as a specific PP2A trimeric holoenzyme. PPP2CB is regulated by inactivating threonine or tyrosine phosphorylation and reversible carboxy methylation. Carboxyl methylation may play a role in holoenzyme assembly; it varies during the cell cycle. PP2A can dephosphorylate p53, and modulate phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP2 kinase activity. In dephosphorylating protein kinases and transcription factors, PPP2CB regulates major metabolic pathways, translation, transcription, and G2/M transition. (NCI) ( NCI )] (UMLS (NCI) C1335540) PPP2CB;
Protein Phosphatase 2 Catalytic Subunit Beta;
Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Beta;
=Amino Acid, Peptide, or Protein; Enzyme ;
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- 4. PP2A B Subunit B Prime Delta
- [Widely expressed (high in brain) as 3 isoforms by human PPP2R5D Gene (PP2A Subunit B Family), 70-kDa Protein Phosphatase 2 Regulatory Subunit B Delta is a cytoplasmic and nuclear regulatory subunit of PP2A in interphase, but nuclear in mitosis. PPP2R5D-1 is serine phosphorylated. A major Ser/Thr phosphatase implicated in negative control of cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Combinations of different subunit isoforms can generate many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. (NCI) ( NCI )] (UMLS (NCI) C1335544) PP2A B Subunit B56 Delta;
PP2A B Subunit PR61 Delta;
PP2A B Subunit R5 Delta;
PPP2R5D;
Protein Phosphatase 2 Regulatory Subunit B Delta;
Protein Phosphatase 2A Regulatory Subunit B56 Delta;
Serine/Threonine Protein Phosphatase 2A 56 kDa Regulatory Subunit Delta =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 9. PPAR Binding Protein Gene
- [This gene plays a role in the transcriptional activation of target genes. It is involved in embryonic fibroblast differentiation and normal development of vital organs. ( NCI )] (UMLS (NCI) C1335237) PPARBP;
PPARBP Gene =Gene or Genome |
- 5. PP2A B Subunit B Prime Epsilon
- [Encoded as two isoforms by human PPP2R5E Gene (Phosphatase 2A Regulatory Subunit B Family), serine phosphorylated 55-kD Protein Phosphatase 2 Regulatory Subunit B Epsilon is a regulatory subunit of PP2A. PPP2R5E is predominantly concentrated in the perinuclear cytoplasm and excluded from the nucleus. A major Ser/Thr phosphatase implicated in negative control of cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Combinations of different subunit isoforms can generate many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. (NCI) ( NCI )] (UMLS (NCI) C1335545) PP2A B Subunit B56 Epsilon;
PP2A B Subunit PR61 Epsilon;
PP2A B Subunit R5 Epsilon;
PPP2R5E;
Protein Phosphatase 2 Regulatory Subunit B Epsilon;
Protein Phosphatase 2A Regulatory Subunit B56 Epsilon;
Serine/Threonine Protein Phosphatase 2A 56 kDa Regulatory Subunit Epsilon =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
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