- 1. PU.1 Transcription Factor
- [Normally expressed in all hematopoietic lineages, except T-cells, the ETS-domain PU.1 Transcription Factor is essential for development of myeloid (osteoclast progenitors) and B-lymphoid cells. Graded PU.1 expression appears to specify distinct cell fates in the hematopoietic system; a low concentration induces the B-cell fate, while a high concentration promotes macrophage differentiation. PU.1 is thought to regulate transcription of FMS and CD18/11B, proteins central to the osteoclast phenotype, and is required for p47-phox promoter activity in myeloid cells. PU.1 expression is increased with the induction of osteoclastogenesis by 1, 25-dihydroxyvitamin D3. (from OMIM 165170 and NCI) ( NCI )] (UMLS (NCI) C0246120) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 4. Putorius furo
- [ ] (UMLS (CSP) C1658569) =Mammal ;
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- 2. putamen
- [largest and most lateral of the basal ganglia lying between the lateral medullary lamina of the globus pallidus and the external capsule; it is part of the neostriatum and forms part of the lentiform nucleus along with the globus pallidus; lesions of the putamen produce athetoid movements on the opposite side of the body. ( CSP )] (UMLS (CSP) C0034169) =Body Part, Organ, or Organ Component ;
=lenticular nucleus;
| - 5. putrescine
- [diamine formed by decarboxylation of arginine and ornithine; a precursor of spermidine. ( CSP )] (UMLS (CSP) C0034170) =Organic Chemical; Neuroreactive Substance or Biogenic Amine =Polyamines;
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