- 1. (6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione
- [A carboline-based compound with vasodilatory properties. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP)-specific type 5 phosphodiesterase- (PDE-5)-mediated degradation of cGMP, which is found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. Inhibition of cGMP degradation by tadalafil results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, thereby prolonged penile erection. ( NCI )] (UMLS (NCI) C1176316) TADALAFIL;
TADALAFIL UNIDENTIFIED =Organic Chemical; Pharmacologic Substance | - 8. RARB
- [This gene is involved in the regulation of embryonic morphogenesis and related processes. ( NCI )] (UMLS (NCI) C1335591) RARB Gene;
Retinoic Acid Receptor, Beta Gene;
=Gene or Genome ;
|
- 2. RAR
- (UMLS (HL7) C1549879) =Idea or Concept =Message structure;
| - 9. Rare Cancer-Associated Syndrome
- (UMLS (NCI) C1335664) =Disease or Syndrome ;
|
- 3. RAR
- [Retinoid receptors (RARA, RARB, RARG) require co-regulators to increase selective binding to DNA response elements in target genes and enhance transcriptional activity. ( NCI )] (UMLS (NCI) C0140278) =Amino Acid, Peptide, or Protein; Receptor ;
| - 10. Rare Disease
- [A non-malignant disease that affects fewer than 200,000 people in the United States. (from National Organization for Rare Disorders) ( NCI )] (UMLS (NCI) C0678236) =Disease or Syndrome ;
|
- 4. RAR - Pharmacy/treatment administration information
- (UMLS (HL7) C1549325) =Health Care Activity =Event Type;
| - 11. RARG
- [This gene plays a role in transcriptional regulation and is involved in morphogenesis. ( NCI )] (UMLS (NCI) C1419272) RARG Gene;
Retinoic Acid Receptor, Gamma Gene =Gene or Genome |
- 5. RAR-Related Orphan Receptor A Gene
- [This gene plays a role in transcriptional regulation and circadian clock regulation. ( NCI )] (UMLS (NCI) C1335634) RORA;
RORA Gene =Gene or Genome ;
| - 12. RARRES3
- [Expressed in many tissues, human RARRES3 Gene (H-REV107 Family) at 11q23 encodes 164-aa 18-kDa Retinoic Acid Receptor Responder Protein 3 thought act as a regulator that mediates some of the growth inhibitory and cell differentiation activities of retinoids. RARRES1, RARRES2, and RARRES3 genes are upregulated by the synthetic retinoid tazarotene. (NCI) ( NCI )] (UMLS (NCI) C1098323) RAR-Responsive Protein TIG3;
Retinoic Acid Receptor Responder Protein 3;
Retinoid Inducible Gene 1 Protein;
Tazarotene-Induced Gene 3 Protein =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 6. RARA
- [A protein that binds retinoic acid with high affinity, RAR alpha is homologous to the steroid receptor superfamily and a retinoic acid-inducible transacting enhancer factor. There are at least two retinoic acid receptors, RAR alpha and RAR beta. Binding of ligand to receptors attracts co-activator proteins containing a NR box. NCOR1 and SMRT contain CoRNR box sequences, similar to the NR box, in receptor interaction domains and mediate inhibition of gene transcription by RARs. Sequences flanking the CoRNR box determine receptor specificity. Differential recognition of receptors by co-activators and co-repressors is due to subtle differences between CoRNR and NR boxes. The association of SMRT with receptors is destabilized by ligand, triggering the activation process. The repressor function of SMRT may promote interaction with transcription factor TFIIB. (from OMIM 180240 and NCI) ( NCI )] (UMLS (NCI) C0140279) =Amino Acid, Peptide, or Protein; Receptor ;
| - 13. RARRES3
- [This gene plays a putative role in the inhibition of cell proliferation. ( NCI )] (UMLS (NCI) C1419275) RARRES3 Gene;
Retinoic Acid Receptor Responder (Tazarotene Induced) 3 Gene =Gene or Genome |
- 7. RARA
- [This gene plays a role in transcription and retinoic acid receptor signal transduction. ( NCI )] (UMLS (NCI) C1366536) RARA Gene;
Retinoic Acid Receptor Alpha Gene =Gene or Genome | |
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