- 1. (2S-cis)-Benzoic Acid[1-[4-[3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3-naphthacenyl]ethylidene]hydrazide
- [A benzoyl-hydrazone derivative of the anthracycline antineoplastic antibiotic daunorubicin. Zorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39590&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39590&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1458" NCI Thesaurus) ( PDQ )] (UMLS (NCI) C0206788) =Organic Chemical; Antibiotic ;
| - 13. Science
- [The intellectual and practical activity encompassing the systematic study of the structure and behaviour of the physical and natural world through observation and experiment. ( NCI )] (UMLS (NCI) C0036397) =Occupation or Discipline ;
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- 2. (8S-cis)-10-((3-Amino-2,3,6-trideoxy-beta-L-arabino-hexopyranosyl)oxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
- [A 4'-epi-isomer of the anthracycline antineoplastic antibiotic doxorubicin. Epirubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation. ( NCI )] (UMLS (NCI) C0014582) =Organic Chemical; Pharmacologic Substance =antineoplastic antibiotics;
(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroacetyl)-1-methoxy-5,12-naphthacenedione =(8S-cis)-10-((3-Amino-2,3,6-trideoxy-beta-L-arabino-hexopyranosyl)oxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione Hydrochloride | - 14. science education
- [instruction in any of the natural scientific disciplines; i.e. physics, chemistry, mathematics, biology, astronomy, earth science, and their subdisciplines and hybrid disciplines (e.g. biochemistry). ( CSP )] (UMLS (CSP) C0597424) =Educational Activity =education;
|
- 3. (8S-cis)-10-((3-Amino-2,3,6-trideoxy-beta-L-arabino-hexopyranosyl)oxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione Hydrochloride
- [The hydrochloride salt of the 4'-epi-isomer of the anthracycline antineoplastic antibiotic doxorubicin. Epirubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation. ( NCI )] (UMLS (NCI) C0700582) =Organic Chemical; Pharmacologic Substance =(8S-cis)-10-((3-Amino-2,3,6-trideoxy-beta-L-arabino-hexopyranosyl)oxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione;
=EPIRUBICIN HCL 2 MG/ML | - 15. scientific organization
- [ ] (UMLS (CSP) C0920650) =Health Care Related Organization ;
|
- 4. (8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroacetyl)-1-methoxy-5,12-naphthacenedione
- [antineoplastic antibiotic obtained from Streptomyces peucetius; a hydroxy derivative of daunorubicin. ( CSP )] (UMLS (NCI) C0013089) =Organic Chemical; Antibiotic ;
=Anthracycline Antibiotic;
antineoplastic antibiotics;
(8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione;
=(8S-cis)-10-((3-Amino-2,3,6-trideoxy-beta-L-arabino-hexopyranosyl)oxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione;
N-trifluoroacetyladriamycin 14-valerate;
14-Hydroxydaunorubicin Hydrochloride;
(8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-tri-hydroxy-1-methoxy-5,12-naphthacenedione Hydrochloride;
14-Hydroxydaunorubicin Hydrochloride;
(8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-tri-hydroxy-1-methoxy-5,12-naphthacenedione Hydrochloride;
| - 16. scientist
- [A person who has studied science, especially one who is active in a particular field of investigation. ( NCI )] (UMLS (NCI) C0402112) =Professional or Occupational Group
|
- 5. (8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-tri-hydroxy-1-methoxy-5,12-naphthacenedione Hydrochloride
- [A liposome-encapsulated form of the hydrochloride salt of the anthracycline antineoplastic antibiotic doxorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids. Liposomal delivery of doxorubicin HCL improves drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic drug effects; a liposomal formulation of doxorubicin also modulates toxicity, specifically the cardiac effects commonly seen with anthracycline antitumor drugs. ( NCI )] (UMLS (NCI) C1445757) Doxorubicin HCl Liposome;
Doxorubicin Hydrochloride Liposomal;
Doxorubicin Hydrochloride Liposome;
DOXORUBICIN HYDROCHLORIDE LIPOSOME PREPARATION;
Liposomal Doxorubicin Hydrochloride;
=Organic Chemical; Antibiotic =(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroacetyl)-1-methoxy-5,12-naphthacenedione;
=DOXORUBICIN HYDROCHLORIDE LIPOSOME 2 MG/ML;
| - 17. Scientology
- (UMLS (HL7) C1552061) =Idea or Concept =Religious Affiliation;
|
- 6. (8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione
- [anthracycline antibiotic produced by Streptomyces coeruleorubidus or Streptomyces peucetius and used as an antineoplastic. ( CSP )] (UMLS (NCI) C0011015) =Organic Chemical; Pharmacologic Substance =Anthracycline Antibiotic;
antineoplastic antibiotics;
Anthracyclines;
=(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroacetyl)-1-methoxy-5,12-naphthacenedione;
(1S,3S)-3-Acetyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-6,11-dioxo-1-naphthacenyl-3-amino-2,3,6-trideoxy-alpha-L-hexopyranoside;
5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S-cis)-, hydrochloride;
DAUNORUBICIN CITRATE LIPOSOME;
5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S-cis)-, hydrochloride;
DAUNORUBICIN CITRATE LIPOSOME | - 18. scintillation counter
- [instrument for detection and counting of scintillations produced in a fluorescent material by ionizing radiation. ( CSP )] (UMLS (CSP) C0036405) =Medical Device ;
=radiation detector;
|
- 7. Sciatia
- [syndrome characterized by pain radiating from the back into the buttock and into the lower extremity along its posterior or lateral aspect, and most commonly caused by protrusion of a low lumbar intervertebral disk; also used to refer to pain anywhere along the course of the sciatic nerve. ( CSP )] (UMLS (ICD9CM) C0036396) =Sign or Symptom ;
=Neuralgia;
DISORDERS OF THE PERIPHERAL NERVOUS SYSTEM;
DORSOPATHIES;
Sciatic Neuropathy | - 19. scintillation spectrometry
- [ ] (UMLS (CSP) C0597425) =Diagnostic Procedure =dosimetry;
spectrometry |
- 8. Sciatic Artery
- (UMLS (NCI) C0226373) =Body Part, Organ, or Organ Component
| - 20. Scirrhous Hepatocellular Carcinoma
- [An uncommon type of hepatocelluar carcinoma, morphologically characterized by significant fibrosis around the sinusoid-like spaces and atrophy of the tumor trabeculae. ( NCI )] (UMLS (NCI) C1266018) Sclerosing Hepatic Carcinoma;
Sclerosing Hepatocellular Carcinoma;
=Neoplastic Process |
- 9. sciatic nerve
- [largest peripheral nerve in human body, consisting of 13 branches; controls leg movements. ( CSP )] (UMLS (CSP) C0036394) =Body Part, Organ, or Organ Component ;
=spinal nerve;
| - 21. Scirrhous Pattern
- (UMLS (NCI) C1335930) =Finding
|
- 10. SCID hu mouse
- [ ] (UMLS (CSP) C0086962) =Mammal
| - 22. Sciuridae
- [A family of the order Rodentia which contains 49 genera. Some of the more common genera are MARMOTA, which includes the marmot and woodchuck; Sciurus, the gray squirrel, S. carolinensis, and the fox squirrel, S. niger; Tamias, the eastern and western chipmunk; and Tamiasciurus, the red squirrel. The flying squirrels, except the scaly-tailed Anomaluridae, also belong to this family. ( MSH )] (UMLS (CSP) C0036409) =Mammal ;
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- 11. SCID interview
- [ ] (UMLS (CSP) C1537054) =Diagnostic Procedure ;
| - 23. Sciuromorpha
- [ ] (UMLS (CSP) C1271401) =Mammal
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- 12. SCID mouse
- [genetically immunodeficient mouse strain used to model human severe combined immunodeficiency syndrome and to construct experimental immunologic chimeras; the most notable artificial chimera is the SCID- hu mouse, which has a virtual human immune system. ( CSP )] (UMLS (CSP) C0085112) =Mammal ;
=laboratory mouse;
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