- 1. (+)-(4S)-4,11-diethyl-4-hydroxy-9-[(4-piperidino-piperidino)carbonyloxy]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinol-3,14,(4H,12H)-dione
- [DNA topoisomerase I inhibitor. ( CSP )] (UMLS (NCI) C0123931) =Organic Chemical; Pharmacologic Substance ;
=[AN000] ANTINEOPLASTICS;
(+)-Camptothecin;
enzyme inhibitor;
=Irinotecan Hydrochloride | - 6. SD
- [A measure of the range of values in a set of numbers. Standard deviation is a statistic used as a measure of the dispersion or variation in a distribution, equal to the square root of the arithmetic mean of the squares of the deviations from the arithmetic mean. ( NCI )] (UMLS (NCI) C0871420) Standard Deviation;
=Quantitative Concept ;
|
- 2. (s)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]-quinoline-3,14(4H,12H)-dione
- [antineoplastic drug which acts as a DNA topoisomerase inhibitor. ( CSP )] (UMLS (NCI) C0146224) =Organic Chemical; Pharmacologic Substance ;
=[AN000] ANTINEOPLASTICS;
(+)-Camptothecin =(S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4'
6,7] indolizino[1,2-b] quinoline-3,14-(4H,12H)-dione monohydrochloride | - 7. SDAV (sialodacryoadenitis virus)
- [ ] (UMLS (CSP) C0598232) =Virus ;
|
- 3. (S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4'
6,7] indolizino[1,2-b] quinoline-3,14-(4H,12H)-dione monohydrochloride - [An oral formulation of hydrochloride salt of topotecan, a semisynthetic derivative of camptothecin, a quinoline alkaloid extracted from the Asian tree Camptotheca acuminate, with potential antineoplastic activity. Topotecan selectively inhibits topoisomerase I activity by stabilizing the topoisomerase I-DNA covalent complexes during S phase of cell cycle, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. Compared to intravenously administered topotecan, the oral formulation is a more convenient way of administering this agent. ( NCI )] (UMLS (NCI) C0886549) Hycamptamine;
Oral Topotecan Hydrochloride;
Topotecan HCl;
Topotecan hydrochloride;
topotecan hydrochloride (oral);
TOPOTECAN HYDROCHLORIDE PREPARATION =Organic Chemical; Pharmacologic Substance ;
=(s)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]-quinoline-3,14(4H,12H)-dione;
=TOPOTECAN HYDROCHLORIDE 4 MG | - 8. SDS PAGE
- [electrophoretic technique for estimating molecular weights of polypeptides by reducing all disulfide bonds, saturating with the anionic detergent sodium dodecylsulfate (SDS), and electrophoresing on polyacrylamide gels. ( CSP )] (UMLS (CSP) C0600209) =Laboratory Procedure; Research Activity ;
=gel electrophoresis;
|
- 4. (S)-dihydroorotate:oxygen oxidoreductase
- [A flavoprotein (FAD, FMN). Catalyzes the reaction of S-dihydroorotate and oxygen into orotate and hydrogen peroxide. Ferricyanide can act as acceptor. [EC 1.3.3.1 created 1961] (from IUBMB) ( NCI )] (UMLS (NCI) C0058099) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 9. SDZ 280-446
- [A novel semi-synthetic derivative of cyclosporin and a cyclodepsipeptide with chemo-sensitizing activity. SDZ 280-446 is one of the drug resistance-modifying agents that inhibit P-glycoprotein, the multidrug resistance efflux pump, thereby restoring the retention and activities of some drugs in drug-resistant tumor cells. ( NCI )] (UMLS (NCI) C0141820) =Amino Acid, Peptide, or Protein; Pharmacologic Substance
|
- 5. SD
- [A state in the northern midwest United States. Its capital is Pierre. ( NCI )] (UMLS (NCI) C0037717) =Geographic Area ;
◊ [A country in Northern Africa, bordering the Red Sea, between Egypt and Eritrea. (NCI) ( NCI )] (UMLS (NCI) C0038642) Geographic Area ; | |
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