- 1. Werdnig Hoffmann paralysis
- [ ] (UMLS (CSP) C0599201) =Disease or Syndrome ;
| - 3. Werner Syndrome Protein
- [The WS gene encodes WRN, a 1,432-amino acid polypeptide. WRN is a member of the RecQ family of DNA helicases that unwind duplex DNA. It can also digest DNA exonucleolytically with 3'-5' polarity. WRN may facilitate pol d-mediated DNA replication and/or DNA repair and disruption of WRN-DNA polymerase delta interaction in WS cells may contribute to the S-phase defects and/or the unusual sensitivity to a limited number of DNA damaging agents. (Proc Natl Acad Sci U S A 2000 Apr 25;97(9):4603-8) ( NCI )] (UMLS (NCI) C0388246) =Amino Acid, Peptide, or Protein; Enzyme ;
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