- 1. WISP1
- [This gene is involved in the regulation of cell adhesion, polarity and proliferation. It also plays a role in the inhibition of apoptosis. ( NCI )] (UMLS (NCI) C1336990) WISP1 Gene;
WNT1 Inducible Signaling Pathway Protein 1 Gene =Gene or Genome ;
◊ [Associated with cell survival and expressed in fibroblasts (high), heart, kidney, lung, pancreas, placenta, ovary, small intestine, and spleen by human WISP1 Gene (WISP/CCN/CTGF Family), 367-aa 40-kDa (precursor) and 280-aa isoforms of secreted WNT1 Inducible Signaling Pathway Protein 1 contain 4 conserved Cys-rich domains: a IGFBP domain, a VWFC domain, a TSP type-1 domain, and a CTCK domain. WISP1 up-regulates anti-apoptotic BCL-X(L) protein and attenuates p53-mediated apoptosis induced by DNA damage through activation of AKT kinase. WISP1 binds to, and may prevent the anti-proliferation activity of, decorin and biglycan, small leucine-rich connective tissue extracellular matrix proteoglycans. WISP1 may act as a downstream regulator in the WNT/Frizzled signaling pathway. (NCI) ( NCI )] (UMLS (NCI) C1449212) WISP1 Protein; WNT1 Inducible Signaling Pathway Protein 1; WNT-1-Induced Secreted Protein; Amino Acid, Peptide, or Protein; Biologically Active Substance | - 3. WISP3
- [This gene plays a role in signal transduction and intercellular signaling. It is involved in postnatal skeletal growth and cartilage homeostasis ( NCI )] (UMLS (NCI) C1421509) WISP3 Gene;
WNT1 Inducible Signaling Pathway Protein 3 Gene =Gene or Genome |
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