[A water-soluble phosphate prodrug of N-acetylcolchinol with potential antineoplastic activity. ZD-6126 binds to and destabilizes the tubulin cytoskeleton of endothelial cells, thereby inhibiting angiogenesis which may result in tumor necrosis. (NCI04) ( NCI )] (UMLS (NCI) C1122629) ZD-6126 =Organic Chemical; Pharmacologic Substance ;