- 201. B Cell Lymphoma Stage IV
- [Stage IV NHL means disseminated (multifocal) involvement of one or more extralymphatic sites with or without associated lymph node involvement or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (PDQ) ( NCI )] (UMLS (NCI) C0855094) B-Cell Lymphoma Stage IV;
Stage IV B Cell Lymphoma;
Stage IV B-Cell Lymphoma;
Stage IV B-Cell Non-Hodgkin Lymphoma;
Stage IV B-Cell Non-Hodgkin's Lymphoma =Neoplastic Process | - 251. B-TFIID
- [The RNA polymerase III initiation factor TFIIIB is assembled onto DNA through interactions involving the Tfc4 subunit of the assembly factor TFIIIC and two subunits of TFIIIB, Brf1 and Bdp1. ( NCI )] (UMLS (NCI) C0076922) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 202. B Cell Proliferation
- [Growth and reproduction of B-lymphocytes. ( NCI )] (UMLS (NCI) C1155008) =Cell Function
| - 252. B-TFIID Subunit Gene
- [Initiation of transcription by RNA polymerase II requires the assistance of TATA box-binding protein (TBP) and TBP-associated factors, or TAFs, in 2 distinct complexes, TFIID and B-TFIID. The majority of TBP is present in the B-TFIID complex, which is composed of TBP and BTAF1. Stable association of TBP and BTAF1 requires the presence of DNA. BTAF1 inhibits TBP-driven RNA polymerase II and III transcription by driving the dissociation of TBP from DNA and freeing the TBP to associate with other TATA boxes or TATA-less promoters. (from OMIM 605191, LocusID 9044) ( NCI )] (UMLS (NCI) C1332364) =Gene or Genome ;
|
- 203. B cell receptor
- [membrane bound version of the specific antibody immunoglobulins produced by B lymphocytes; when BCR is occupied by antigen and the B cell is stimulated with interleukin 2, the B cell becomes activated to produce antibodies. ( CSP )] (UMLS (CSP) C0034789) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor =antigen receptor;
| - 253. B01, B02
- (UMLS (HL7) C1549851) =Intellectual Product =Message structure;
|
- 204. B Cell-Associated Molecule CD40
- [50 kD glycoprotein expressed on all B cells; plays an important role in B cell development and activation. ( CSP )] (UMLS (NCI) C0054959) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor =CD antigen;
| - 254. B03
- (UMLS (HL7) C1549852) =Intellectual Product =Message structure;
|
- 205. B Double Prime
- [Encoded by human PR48 Gene (PP2A Regulatory Subunit B Family), 414-aa nuclear Protein Phosphatase 2A 48kDa Regulatory Subunit is a B regulatory subunit of PP2A. PR48 specifically interacts with the N-terminal region of and dephosphorylates CDC6, modulating initiation of DNA replication and cell cycle control. A major heterotrimeric Ser/Thr phosphatase implicated in negative control of many cellular processes including cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Combinations of different subunit isoforms can generate many forms of PP2A that may differ in substrate specificity, subcellular location, or tissue specific expression. (NCI) ( NCI )] (UMLS (NCI) C1335537) NY-REN-8;
NY-REN-8 Antigen;
PP2A B Double Prime Subunit PR48;
PP2A Subunit B PR48 Isoform;
PR48;
Protein Phosphatase-2A-48kDa Regulatory Subunit;
Serine/Threonine Protein Phosphatase 2A 48kDa Regulatory Subunit;
Serine/Threonine Protein Phosphatase 2A 48kDa Regulatory Subunit B =Amino Acid, Peptide, or Protein; Enzyme ;
| - 255. B04, B05, B06
- (UMLS (HL7) C1549853) =Intellectual Product =Message structure;
|
- 206. B Double Prime 1, Subunit of RNA Polymerase III Transcription Initiation Factor IIIB Gene
- [This gene plays a role in transcriptional initiation. ( NCI )] (UMLS (NCI) C1332409) BDP1;
BDP1 Gene;
=Gene or Genome ;
| - 256. B07
- (UMLS (HL7) C1549854) =Intellectual Product =Message structure;
|
- 207. B lymphocyte depletion therapy
- [ ] (UMLS (CSP) C1171324) =Therapeutic or Preventive Procedure
| - 257. B08
- (UMLS (HL7) C1549855) =Intellectual Product =Message structure;
|
- 208. B Lymphocyte Kinase
- [Encoded by the BLK gene, p55-BLK is a non-receptor protein tyrosine kinase member of the SRC protooncogene family and, on the basis of its preferential expression in B-lymphoid cells, it may function in a signal transductory pathway specific to this lineage. Expression of BLK in immature T-cells suggests that it may play an important role in thymopoiesis. The protein has SH3, SH2, and catalytic domains that contain SRC tyrosine kinase family consensus sequences. (from OMIM 191305 and NCI) ( NCI )] (UMLS (NCI) C0218989) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 258. B1
- [Expressed during B-cell ontogeny (early pre-B-cell to plasma cell) by human CD20 Gene (MS4A Family), 297-aa 33-kDa CD20 Antigen is a phosphorylated cell surface integral membrane protein shown to participate in B-cell proliferation, development, and differentiation into plasma cells. MS4A family proteins share structural similarity, sequence homology, and unique expression patterns among hematopoietic cells and nonlymphoid tissues. MS4A proteins contain 4 highly conserved transmembrane domains, flanked by N- and C-terminal cytoplasmic regions. CD20 may be involved in regulation of B-cell activation and may be regulated by protein kinases. (NCI) ( NCI )] (UMLS (NCI) C0054946) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
|
- 209. B Lymphoid Tyrosine Kinase Gene
- [This gene is involved in signal transduction in B lymphocytes. ( NCI )] (UMLS (NCI) C1332419) BLK;
BLK Gene;
=Gene or Genome | - 259. B12 DEFIC ANEMIA NEC
- [ ] (UMLS (ICD9CM) C0154289) =Disease or Syndrome
|
- 210. B Melanoma Antigen
- [The BAGE gene family encodes CT antigens, recognized by cytotoxic T-lymphocytes. BAGE is expressed in normal adult testis and in some melanomas, infiltrating bladder carcinomas, mammary carcinomas, head and neck squamous cell carcinomas, and non-small cell lung carcinomas. The function of BAGE protein is unknown. ( NCI )] (UMLS (NCI) C1447354) BAGE;
BAGE Tumor Antigen =Amino Acid, Peptide, or Protein; Immunologic Factor | - 260. B16 Malignant Melanoma
- (UMLS (NCI) C0004565) =Experimental Model of Disease; Neoplastic Process
|
- 211. B Prime Alpha Regulatory Subunit
- [Ubiquitously expressed as 3 isoforms by human PPP2R5C Gene (PP2A Subunit B Family), Protein Phosphatase 2 Regulatory Subunit B Gamma is a regulatory subunit of PP2A. Nuclear Gamma-3 is serine phosphorylated, while nuclear Gamma-1 is not. A major Ser/Thr phosphatase implicated in negative control of cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Different subunit isoforms can generate many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. (NCI) ( NCI )] (UMLS (NCI) C1335546) B56G;
PP2A B Subunit B Prime Gamma;
PP2A B Subunit B56 Gamma;
PP2A B Subunit PR61 Gamma;
PP2A B Subunit R5 Gamma;
PPP2R5C;
Protein Phosphatase 2 Regulatory Subunit B Gamma;
Protein Phosphatase 2A Regulatory Subunit B56 Gamma;
Serine/Threonine Protein Phosphatase 2A 56 kDa Regulatory Subunit Gamma =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 261. B19 virus
- [The type species of ERYTHROVIRUS and the etiological agent of ERYTHEMA INFECTIOSUM, a disease most commonly seen in school-age children. ( MSH )] (UMLS (CSP) C0085274) =Virus ;
|
- 212. B Prolymphocytic Leukemia
- [A malignant B-cell lymphoproliferative process affecting the blood, bone marrow, and spleen. The B-prolymphocytes are medium-sized, round lymphoid cells with prominent nucleoli. The B-prolymphocytes must exceed 55% of lymphoid cells in the blood. Cases of transformed chronic lymphocytic leukemia (CLL) and CLL with increased prolymphocytes are excluded. The prognosis is poor. (WHO, 2001) ( NCI )] (UMLS (NCI) C0475801) =Neoplastic Process
| - 262. B2036-PEG
- [ ] (UMLS (CSP) C0768710) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Hormone
|
- 213. B virus
- [virus which naturally infects Asiatic monkeys; causes vesicular lesions of the tongue and lips, acute encephalitis, and almost always death in humans. ( CSP )] (UMLS (CSP) C0019378) =Virus =Alphaherpesvirinae;
| - 263. B23 Nuclear Matrix Protein
- [Nucleophosmin is a nucleolar phosphoprotein that is more abundant in tumor cells than in normal resting cells. Stimulation of the growth of normal cells, e.g., mitogen activation of B lymphocytes, is accompanied by an increase in nucleophosmin protein level. Although the function of nucleophosmin has not been defined precisely, ample evidence suggests that it is involved in the assembly of ribosomal proteins into ribosomes. Electron microscopic study indicates that nucleophosmin is concentrated in the granular region of the nucleolus, where ribosome assembly occurs. (from OMIM) ( NCI )] (UMLS (NCI) C0069141) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 214. B-Cell Activation
- [A set of events occurring in B lymphocytes following stimulation with cognate antigen. Crosslinking the B cell antigen receptor (surface immunoglobulin) leads to increased expression of MHC class II molecules, exit from the resting state (G0) into the G1 phase of the cell cycle, and in the case of a strong antigenic stimulus, proliferation. ( NCI )] (UMLS (NCI) C1155003) =Cell Function
| - 264. B2M
- [This gene plays a role in immune responses. ( NCI )] (UMLS (NCI) C1412709) B2M Gene;
Beta-2-Microglobulin Gene =Gene or Genome ;
|
- 215. B-Cell Activation Protein BL34
- [Induced in response to several activation signals and encoded by B-cell specific immediate early human RGS1 Gene (RGS Family), 196-aa 22.5-kDa Regulator of G-Protein Signaling 1, containing 1 RGS domain, is likely involved in regulation of B-cell activation and proliferation. Potentially regulated by protein kinase(s), RGS1 inhibits signal transduction by increasing GTPase activity of G protein alpha subunits, driving them into the inactive GDP-bound form. ( NCI )] (UMLS (NCI) C1448758) Early Response Protein 1R20;
Regulator of G-Protein Signaling 1;
RGS1;
=Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 265. B2R
- [Bradykinin Receptor B2, encoded by the BDKRB2 gene, is a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. (from LocusLink) ( NCI )] (UMLS (NCI) C0914912) BDKRB2;
BK2;
BK-2;
BKR2;
Bradykinin Receptor B2;
BRB2 =Amino Acid, Peptide, or Protein; Receptor ;
|
- 216. B-Cell Chronic Lymphocytic Leukemia Tumor Suppressor LEU5
- [Encoded by human RFP2 Gene (TRIM Family), 407-aa 47-kDa RET Finger Protein 2, of unknown function, is localized to cytoplasmic bodies near the nucleus and contains a TRIM motif: 3 zinc-binding domains, a RING, type 1 and type 2 B-boxes, and a coiled-coil region. RFP2 may act as a tumor suppressor and may be involved in 13q14 deletion B-CLL. (NCI) ( NCI )] (UMLS (NCI) C1308524) CLL-Associated RING Finger;
Leukemia Associated Protein 5;
Putative Tumor Suppressor RFP2;
RET Finger Protein 2;
Tripartite Motif Protein 13 =Amino Acid, Peptide, or Protein; Biologically Active Substance | - 266. B3 (dsFv)-PE38
- [A toxic substance linked to an antibody that attaches to tumor cells and kills them. ( NCI )] (UMLS (NCI) C0678023) =Pharmacologic Substance; Immunologic Factor
|
- 217. B-Cell CLL Protein
- [Expressed in thymus, prostate, testis, ovary, small intestine, spleen, colon, and blood, 85-kb human BCL9 Gene at 1q21 encodes 1426-aa 150-kD nuclear B-Cell Lymphoma 9 Protein, containing an HD1 domain that interacts with the conserved PHD finger of PYGO1 and PYGO2. BCL9 (Lgs homolog, Drosophila) also binds to beta-Catenin, involved in WNT signal transduction pathway control of many fundamental developmental processes. BCL9 recruitment of PYGO to beta-Catenin may permit association with DNA-binding TCF to transcriptionally activate WNT target genes. BCL9 translocation that leaves the coding region intact is associated with B-cell acute lymphoblastic leukemia. ( NCI )] (UMLS (NCI) C0672585) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 267. B3 antigen
- [B cell specific adhesion molecule; active in adhesion to monocytes and T cells. ( CSP )] (UMLS (CSP) C0054947) =Amino Acid, Peptide, or Protein; Receptor ;
=CD antigen;
Adhesion Molecule |
- 218. B-Cell CLL Protein
- [Encoded by widely expressed human BCL7A Gene, 231-aa 25-kD serine-rich BCL7A Protein has 90% sequence identity (N-terminal 51-aa) with BCL7B and BCL7C; possible members of an evolutionarily conserved family. BCL7A exhibits no recognizable motifs but shows homology with actin-binding Caldesmon. Recurrent three-way translocations of BCL7A with MYC and IGH occur in a high-grade B cell non-Hodgkin (Burkitt) lymphoma; the N-terminal BCL7A region is disrupted. ( NCI )] (UMLS (NCI) C1307696) BCL7A;
BCL7A Protein;
Lymphoma 7A Protein;
=Amino Acid, Peptide, or Protein; Biologically Active Substance | - 268. B3(Fv)-PE38
- [A toxic substance linked to an antibody that attaches to tumor cells and kills them. ( NCI )] (UMLS (NCI) C0296314) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Immunologic Factor
|
- 219. B-Cell CLL/Lymphoma 10
- [The gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. (LocusLink) ( NCI )] (UMLS (NCI) C0766164) BCL10;
CARD-Containing Proapoptotic Protein;
CARD-Like Apoptotic Protein;
Caspase-Recruiting Domain-Containing Protein;
=Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 269. B3-NLysPE38
- [A toxic substance linked to an antibody that attaches to tumor cells and kills them. ( NCI )] (UMLS (NCI) C0796420) Immunotoxin LMB-1;
LMB-1;
LMB-1 Immunotoxin =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Immunologic Factor |
- 220. B-Cell CLL/Lymphoma 10 Gene
- [This gene is involved in the promotion of apoptosis. ( NCI )] (UMLS (NCI) C1367449) BCL10;
BCL10 Gene =Gene or Genome | - 270. B4
- [CD antigen expressed on B cell surface; forms signal transduction complex with CD21 (CR2) and CD81 (TAPA-1). ( CSP )] (UMLS (NCI) C0108748) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
=CD antigen;
|
- 221. B-Cell CLL/lymphoma 2
- [A mitochondrial membrane protein, BCL-2 protein is responsible for blocking apoptosis in normal cells. Growth factor-stimulated phosphorylation by PKC promotes anti-apoptotic activity of BCL-2 during G2/M. BCL-2 regulates cell death by controlling mitochondrial membrane permeability. Cleavage by caspases during apoptosis yields a pro-apoptotic BCL-2 product that causes release of cytochrome C into the cytosol, promoting further caspase activity. Over expression from translocation t(14;18) of BCL-2 with the immunoglobulin gene region is involved in B-cell lymphomas. (from OMIM 151430 and NCI) ( NCI )] (UMLS (NCI) C0597712) =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 271. B4 antigen
- [ ] (UMLS (CSP) C0483254) =Amino Acid, Peptide, or Protein; Immunologic Factor
|
- 222. B-Cell CLL/Lymphoma 2 Gene
- [This gene is involved in apoptotic regulation. Overexpression of this gene promotes the pathogenesis of B-Cell lymphomas, due to anti-apoptotic activity. ( NCI )] (UMLS (NCI) C0376515) =Gene or Genome
| - 272. B43-Genistein Immunoconjugate
- [An immunoconjugate comprised of an anti-CD19 monoclonal antibody conjugated with Genistein selectively targeting B-lineage progenitor cells and inhibiting protein tyrosine kinase, causing apoptosis. ( NCI )] (UMLS (NCI) C0879422) =Organic Chemical; Pharmacologic Substance; Immunologic Factor
|
- 223. B-Cell CLL/Lymphoma 3
- [A possible transcriptional activating factor, BCL3 is activated by phosphorylation and functions as an IKB specific for the p50 subunit of NFKB, inhibiting its translocation to the nucleus. BCL3 confers a survival advantage to T-cells, possibly by promoting the expression of genes repressed by NFKB members. Translocation t(14;19)(q32;q13.1), involving BCL3 and immunoglobulin gene regions, is associated with B-CLL. (from OMIM 109560 and NCI) ( NCI )] (UMLS (NCI) C0640485) =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 273. B43-PAP
- [An immunotoxin comprised of a ribosome inhibitory plant toxin, Pokeweed Antiviral Protein (PAP), conjugated with a murine IgG1 anti-CD19 monoclonal antibody selectively targeting B-lineage progenitor cells, causing apoptosis. ( NCI )] (UMLS (NCI) C0796424) B43-PAP Immunotoxin;
B43-Pokeweed Antiviral Protein Immunotoxin;
=Amino Acid, Peptide, or Protein; Pharmacologic Substance; Immunologic Factor |
- 224. B-Cell CLL/Lymphoma 3 Gene
- [This gene is involved in transcriptional co-activation and signal transduction. ( NCI )] (UMLS (NCI) C0812238) BCL3;
BCL3 Gene =Gene or Genome | - 274. B43.13
- [A murine monoclonal antibody that attaches to the tumor-associated antigen CA125. Vaccination with monoclonal antibody B43.13 may stimulate a host cytotoxic immune response against tumor cells that express CA125. (NCI04) ( NCI )] (UMLS (NCI) C0664207) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Immunologic Factor
|
- 225. B-Cell CLL/Lymphoma 6 (Zinc Finger Protein 51) Gene
- [This gene is involved in transcriptional repression and plays a role in the modulation of B-cell responses. ( NCI )] (UMLS (NCI) C1332399) B-Cell CLL/Lymphoma-6 Gene;
BCL5;
BCL6;
BCL6 Gene;
Cys-His2 Zinc Finger Transcription Factor Gene;
LAZ3;
LAZ-3 Gene;
Lymphoma-Associated Zinc Finger Gene on Chromosome 3;
Zinc Finger Protein 51 Gene;
ZNF51;
ZNF51 Gene =Gene or Genome ;
| - 275. B4B Protein
- [epithelial membrane protein-1. Thought to be involved in cell-cell interactions and the control of cell proliferation. Found to be highly expressed in brain tumor cells but not in normal brain. ( NCI )] (UMLS (NCI) C0384479) =Amino Acid, Peptide, or Protein; Receptor ;
|
- 226. B-Cell CLL/Lymphoma 7A Gene
- (UMLS (NCI) C1332400) BCL7A;
BCL7A Gene;
=Gene or Genome ;
| - 276. B5T Overexpressed Gene Protein
- [Widely expressed as two alternative transcript variants by human RBBP9 Gene, 186-aa 21-kDa nuclear/cytoplasmic Retinoblastoma Binding Protein 9 confers resistance to TGF-Beta 1 growth inhibition through interaction with Rb and subsequent displacement of E2F-1 and may play a role in regulation of cell proliferation and differentiation. (NCI) ( NCI )] (UMLS (NCI) C1313695) BOG Protein;
RBBP10;
RBBP9;
Retinoblastoma Binding Protein 9;
Retinoblastoma-Binding Protein 10;
=Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 227. B-Cell CLL/Lymphoma 9 Gene
- [This gene plays a role in signal transduction and is involved in development. ( NCI )] (UMLS (NCI) C1332402) BCL9;
BCL9 Gene;
=Gene or Genome ;
| - 277. B7
- [A member of the immunoglobulin gene super family. Co-regulator of T cell activation with CD86. Plays a critical role in autoimmune, humoral, and transplant responses. Expressed on activated T and B cells and on macrophages. (from PROW) ( NCI )] (UMLS (NCI) C0104998) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
|
- 228. B-cell CLL/Lymphoma-6
- [B-Cell Lymphoma 6 Protein is a zinc finger transcription factor containing an N-terminal POZ domain. It acts as a sequence-specific repressor of transcription and its activity is dependent upon DNA-binding and on the N-terminal region containing the POZ motif. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. Target genes have roles in B-cell activation, B-cell differentiation, inflammation, and cell cycle control. Expression of BCL6 in some B-cells early in the antigen response may skew them toward a germinal center fate, away from a plasma cell fate. The BCL6 gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. (from OMIM, LocusLink and NCI) ( NCI )] (UMLS (NCI) C0248007) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 278. B8509-035
- (UMLS (NCI) C0285635) =Organic Chemical; Pharmacologic Substance ;
|
- 229. B-Cell Deficiency
- (UMLS (NCI) C0522274) =Disease or Syndrome
| - 279. BA
- [An archipelago in the Persian Gulf, east of Saudi Arabia. (NCI) ( NCI )] (UMLS (NCI) C0004684) =Geographic Area ;
◊ [The artery formed by the union of the right and left vertebral arteries; it runs from the lower to the upper border of the pons, where it bifurcates into the two posterior cerebral arteries. ( MSH )] (UMLS (NCI) C0004811) Body Part, Organ, or Organ Component ◊ [A country in Southeastern Europe, bordering the Adriatic Sea and Croatia. (NCI) ( NCI )] (UMLS (NCI) C0006036) Geographic Area ; Europe; |
- 230. B-Cell Diffuse Large Cell Lymphoma of Mediastinum
- [A large B-cell non-Hodgkin lymphoma arising in the mediastinum. Morphologically it is characterized by a massive diffuse lymphocytic proliferation associated with compartmentalizing fibrosis. Response to intensive chemotherapy, with or without radiotherapy, is usually good. (WHO, 2001) ( NCI )] (UMLS (NCI) C0855152) B-Cell Diffuse Large Cell Lymphoma of the Mediastinum;
Mediastinal (Thymic) Large B-Cell Lymphoma;
Mediastinal B-Cell Diffuse Large Cell Lymphoma;
Primary Mediastinal Large B-Cell Lymphoma =Neoplastic Process | - 280. Ba
- [alkaline earth element, atomic symbol Ba, atomic number 56, and atomic weight 138; all of its acid-soluble salts are poisonous. ( CSP )] (UMLS (NCI) C0004749) =Element, Ion, or Isotope ;
|
- 231. B-Cell Lineage Specific Activator Protein
- [Paired Box 5, encoded by the PAX5 gene, is a member of the paired box (PAX) family of transcription factors. Paired Box 5 is expressed at early stages of B-cell differentiation. Its expression is also detected in developing CNS and testis. Paired Box 5 may not only play an important role in B-cell differentiation, but also in neural development and spermatogenesis. This gene is located in chromosome 9p13 region, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoters. Deregulation of PAX5 gene transcription may contribute to the pathogenesis of these lymphomas. (from LocusLink) ( NCI )] (UMLS (NCI) C0167636) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 281. Ba++ element
- [ ] (UMLS (CSP) C0920767) =Element, Ion, or Isotope
|
- 232. B-Cell Linker Gene
- [This gene plays a role in signal transduction and B-cell development. ( NCI )] (UMLS (NCI) C1332420) BLNK;
BLNK Gene;
=Gene or Genome | - 282. BA-163
- (UMLS (NCI) C0878534) =Organic Chemical; Antibiotic
|
- 233. B-Cell Lymphocytic Neoplasm
- (UMLS (NCI) C1332362) B-Cell Neoplasm;
=Neoplastic Process ;
| - 283. BA34647
- (UMLS (NCI) C0729183) =Amino Acid, Peptide, or Protein; Pharmacologic Substance
|
- 234. B-Cell Lymphoma Recurrent
- [The reemergence of B-cell non-Hodgkin lymphoma after a period of remission ( NCI )] (UMLS (NCI) C0855089) Recurrent B-Cell Lymphoma;
Recurrent B-Cell Non-Hodgkin Lymphoma;
Recurrent B-Cell Non-Hodgkin's Lymphoma =Neoplastic Process | - 284. BA445H22.2
- [Encoded by human oncogene WISP2 Gene, the 250-amino acid WNT1 Inducible Signaling Pathway Protein 2 constitutes - with WISP1 and WISP3 - one of three factors downstream in the WNT signaling pathway relevant to malignant transformation. WISP2 expression is reduced in 79% of human colon tumors; WISP1 and WISP3 are over expressed in colon tumors. (OMIM, Swiss-Prot, LocusLink, and NCI) ( NCI )] (UMLS (NCI) C0768664) Connective Tissue Growth Factor-Like Protein WISP2;
WISP2;
WISP2 Protein;
WNT1 Inducible Signaling Pathway Protein 2 =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 235. B-Cell Lymphoma Refractory
- [B-cell non-Hodgkin lymphoma that is resistant to treatment ( NCI )] (UMLS (NCI) C0855090) Refractory B-Cell Lymphoma;
Refractory B-Cell Non-Hodgkin Lymphoma;
Refractory B-Cell Non-Hodgkin's Lymphoma =Neoplastic Process | - 285. BA512J3.1
- [Predominantly expressed in neural tissues and encoded by human LGI1 Gene, a 557-amino acid 64-kD precursor yields mature 60-kD putative tumor suppressor Leucine-Rich Glioma-Inactivated Protein, containing a putative extracellular N-terminus and hydrophobic transmembrane segment, as well as leucine-rich repeats (LRR) with conserved cysteine-rich flanking sequences. LGI1 shows high similarity in the LRR domain with transmembrane and extracellular receptors and adhesion proteins. Translocation rearrangements of LGI1 reduce or abrogate expression in several glioblastomas and brain tumors. LGI1 mutations appear responsible for autosomal dominant partial epilepsy with auditory features. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C0761756) Epitempin 1;
Leucine-Rich Glioma-Inactivated 1;
Leucine-Rich Glioma-Inactivated Protein;
Leucine-Rich Glioma-Inactivated Protein 1;
LGI1;
LGI1 Protein;
=Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 236. B-Cell Proliferation of Uncertain Malignant Potential
- (UMLS (NCI) C1332363) =Neoplastic Process ;
| - 286. Babanki virus
- [ ] (UMLS (CSP) C0597804) =Virus ;
|
- 237. B-Cell Small Lymphocytic Lymphoma
- [A non-Hodgkin lymphoma composed of monomorphic small, round B-lymphocytes in the lymph nodes. When the lymphoid process involves predominantly the bone marrow and the peripheral blood it is called chronic lymphocytic leukemia. (WHO, 2001) ( NCI )] (UMLS (NCI) C0855095) Diffuse Well Differentiated Lymphocytic Lymphoma;
Lymphoma, Small Lymphocytic;
SLL;
Small B-Cell Lymphocytic Lymphoma;
Small Lymphocytic Lymphoma =Neoplastic Process =Lymphoma, Small-Cell;
Lymphoma, Diffuse;
Low Grade Lymphoma;
| - 287. Babesia
- [genus of tick borne protozoan parasites that infests the red blood cells of mammals, including humans; there are many recognized species, and the distribution is world wide. ( CSP )] (UMLS (CSP) C0004572) =Invertebrate ;
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- 238. B-Cell Small Lymphocytic Lymphoma Refractory
- [B-cell small lymphocytic lymphoma that is resistant to treatment ( NCI )] (UMLS (NCI) C0855097) Refractory B-Cell Small Lymphocytic Lymphoma;
Refractory Small Lymphocytic Lymphoma;
=Neoplastic Process | - 288. babesiasis
- [tickborne disease caused by infection with protozoa; occurs in wild and domestic animals; in humans causes malaria-like symptoms, myalgia, nausea and splenomegaly; classic zoonotic disease. ( CSP )] (UMLS (CSP) C0004576) =Disease or Syndrome ;
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- 239. B-Cell Small Lymphocytic Lymphoma Stage I
- [Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).- 2003 ( NCI )] (UMLS (NCI) C0855098) Small Lymphocytic Lymphoma Stage I;
Stage I B-Cell Small Lymphocytic Lymphoma;
Stage I Small Lymphocytic Lymphoma =Neoplastic Process | - 289. Babi & Baha'I faiths
- (UMLS (HL7) C1552040) =Idea or Concept =Religious Affiliation;
|
- 240. B-Cell Small Lymphocytic Lymphoma Stage II
- [Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003 ( NCI )] (UMLS (NCI) C0855099) Small Lymphocytic Lymphoma Stage II;
Stage II B-Cell Small Lymphocytic Lymphoma;
Stage II Small Lymphocytic Lymphoma =Neoplastic Process | - 290. Babinski's Phenomenon
- [An abnormal reflex consisting of dorsiflexion of the great toe and abduction of the other toes in response to cutaneous stimulation of the plantar surface of the foot. ( MSH )] (UMLS (NCI) C0034935) =Finding ;
=ABNORMAL REFLEX;
|
- 241. B-Cell Small Lymphocytic Lymphoma Stage III
- [Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003 ( NCI )] (UMLS (NCI) C0855100) Small Lymphocytic Lymphoma Stage III;
Stage III B-Cell Small Lymphocytic Lymphoma;
Stage III Small Lymphocytic Lymphoma =Neoplastic Process | - 291. BABL
- [HMGA2 is a nuclear phosphoprotein that contains three short DNA-binding domains (AT-hooks) and a highly acidic C-terminus. The expression of the gene is cell-cycle regulated. It is likely that the HMGA2 protein acts as an architectural transcription factor, regulating the expression of one or more genes that control embryonic cell growth. Since HMGA2 binds to the minor groove of AT-rich DNA this interaction could be a target for minor groove chemotherapeutic agents in the treatment of sarcomas expressing the rearranged gene. (Int J Biochem Cell Biol 1998 Jul;30(7):761-6) ( NCI )] (UMLS (NCI) C0122111) =Amino Acid, Peptide, or Protein; Biologically Active Substance
|
- 242. B-Cell Small Lymphocytic Lymphoma Stage IV
- [Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003 ( NCI )] (UMLS (NCI) C0855101) Metastatic Small Lymphocytic Lymphoma;
Small Lymphocytic Lymphoma Stage IV;
Stage IV B-Cell Small Lymphocytic Lymphoma;
Stage IV Small Lymphocytic Lymphoma;
=Neoplastic Process | - 292. baboon
- [large terrestrial monkey found in Africa and Arabia; has long doglike muzzle, large cheek pouches, and a short tail. ( CSP )] (UMLS (CSP) C0030362) =Mammal ;
=Cercopithecidae;
|
- 243. B-Cell Translocation Gene 2 Protein
- [This protein is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This protein is involved in the regulation of the G1/S transition of the cell cycle. (LocusLink) ( NCI )] (UMLS (NCI) C1505113) BTG Family, Member 2;
BTG2;
BTG2 Protein;
NGF-Inducible Anti-Proliferative Protein PC3 =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 293. baboon herpesvirus
- [ ] (UMLS (CSP) C0598475) =Virus ;
|
- 244. B-cell/myeloid kinase
- [May serve as part of a signaling pathway coupling the FC receptor to the activation of the respiratory burst. Furthermore, it may also contribute to neutrophil migration and may regulate the degranulation process of neutrophils. p60-HCK and p59-HCK are produced by alternative initiation from the same proto-oncongene HCK. Both are expressed predominantly in cells of the myeloid and b-lymphoid lineages, thus also called B-cell/Myeloid kinase. Contains 1 sh2 domain and 1 sh3 domain. Has been mapped to chromosomal location 20q11-q12. ( NCI )] (UMLS (NCI) C0919495) Hemopoietic Cell Kinase p60;
p60-HCK;
=Amino Acid, Peptide, or Protein; Enzyme | - 294. baby
- [In an obstetric service, the baby. ( HL7V3.0 )] (UMLS (HL7) C1550504) =Idea or Concept =direct target;
|
- 245. B-CEPP
- (UMLS (NCI) C0279240) =Therapeutic or Preventive Procedure ;
| - 295. baby boom
- [ ] (UMLS (CSP) C0004578) =Human-caused Phenomenon or Process ;
|
- 246. B-COMPLEX DEFIC NEC
- [ ] (UMLS (ICD9CM) C0029523) =Disease or Syndrome ;
| - 296. baby food
- [anything which, when taken into the infant body, serves to nourish or build up the tissues or to supply body heat; typically liquids or pureed food until the baby develops teeth; includes baby formula. ( CSP )] (UMLS (CSP) C0021274) =Food =food;
|
- 247. B-DNA
- [A duplex of DNA is formed by two complementary chains that are arranged in an anti-parallel manner. B-DNA is about 20 Angstrom in diameter and a right-handed double helix with a wide major groove easily accessible to proteins and narrow minor groove. B-DNA is the most common DNA conformation in vivo and the favored conformation at high water concentrations. Base pairs are nearly perpendicular to the helix axis and sugar pucker is C2'-endo. ( NCI )] (UMLS (NCI) C0919262) B-Form DNA;
Right-Handed DNA =Nucleic Acid, Nucleoside, or Nucleotide; Biologically Active Substance ;
| - 297. baby formula
- [Liquid formulations for the nutrition of INFANTS, useful for those with special needs or MILK HYPERSENSITIVITY or those whose mothers are unable to breastfeed (BREAST FEEDING). ( MSH )] (UMLS (CSP) C0150589) =Food
|
- 248. B-Double Prime 1 Subunit of RNA Polymerase III Transcription Initiation Factor IIIB
- [Encoded by widely expressed human BDP1 Gene, 2254-aa 253-kD highly hydrophilic Transcription Factor-Like Nuclear Regulator contains several potential phosphorylation sites, two bipartite NLS, a DNA-ligase A1 ATP-dependent binding site, a MYB-like domain, and 9 copies of a 55-amino acid motif. Similar to yeast TFC5 and required for RNA polymerase III transcription, BDP1 binds promoter regions, suggesting that it is part of the initiation complex. (NCI) ( NCI )] (UMLS (NCI) C0966598) BDP1;
hB-Double Prime;
HSA238520;
KIAA1241;
KIAA1689;
Putative Transcription Factor-Like Nuclear Regulator;
Putative Transcription Regulation Nuclear Protein;
RNA Polymerase III GTF3B Subunit 1;
TAF3B1;
TATA Box Binding Protein (TBP)-Associated Factor;
TFC5;
TFIIIB150;
TFIIIB90;
TFNR;
Transcription Factor-Like Nuclear Regulator =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 298. BAC
- [Based upon the natural F plasmid of E. coli. Inserts up to 300 Kb can be cloned and stably maintained as circular molecules. ( NCI )] (UMLS (NCI) C0887889) Bacterial Artificial Chromosome =Research Device ;
|
- 249. B-Protein
- [shares 40% amino acid homology with sequence of mouse tyrosinase; has no tyrosinase activity; converts 5,6-dihydroxyindole-2-carboxylic acid to melanochrome in premelanosomes ( NCI )] (UMLS (NCI) C1455498) Catalase B;
Glycoprotein 75;
TRP-1;
Tyrosinase Related Protein-1;
Tyrosinase-Related Protein 1;
TYRP;
TYRP1;
=Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 299. BAC (bacterial artificial chromosome)
- [ ] (UMLS (CSP) C0872331) =Gene or Genome ;
|
- 250. B-Related Factor 1
- [Encoded by human BRF1 Gene (TFIIB Family), alternative isoforms 1 (677-aa, 74-kD), 2 (134-aa, altered N- and C-termini), 3 (473-aa, shorter N-terminus), and 4 (242-aa) of General Transcription Factor 3B 90-kD Subunit function at different promoters on tRNA, 5S rRNA, and other small RNA genes. Related to GTF2B (N-terminus), GTF3B contains a highly charged region and HMG2-related region. Essential for transcription initiation, GTF3B (C-terminus) binds TBP (collectively, TFIIIB) as one of three RNA polymerase III transcription factor subunits. Following GTF3A or GTF3C recognition of promoter elements, GTF3B and RNA polymerase III bind sequentially. (NCI) ( NCI )] (UMLS (NCI) C1096984) BRF;
BRF1;
BRF1 Homolog;
BRF1 Homolog Subunit of RNA Polymerase III Transcription Initiation Factor IIIB;
BRF1, S. cerevisiae, Homolog of;
BRF1: BRF1 Homolog, Subunit of RNA Polymerase III Transcription Initiation Factor IIIB (S.cerevisiae);
General Transcription Factor 3B 90-kD Subunit;
General Transcription Factor 3B, 90-kD Subunit;
General Transcription Factor IIIB 90kD Subunit;
GTF3B;
GTF3B 90-kD Subunit;
GTF3B, 90-kD Subunit;
hBRF;
TAF3B2;
TAF3C;
TAFIII90;
TATA Box Binding Protein (TBP)-Associated Factor 3C;
TATA Box Binding Protein (TBP)-Associated Factor RNA Polymerase III Subunit 2;
TATA Box-Binding Protein-Associated Factor RNA Polymerase III Subunit 2;
TATA Box-Binding Protein-Associated Factor, RNA Polymerase III, Subunit 2;
TBP-Associated Factor RNA Polymerase III 90kD;
TBP-Associated Factor, RNA Polymerase III, 90-kD;
TF3B90;
TFIIIB90;
Transcription Factor IIIB 90-kD Subunit;
Transcription Factor IIIB, 90-kD Subunit;
Transcription Initiation Factor IIIB =Amino Acid, Peptide, or Protein; Biologically Active Substance | - 300. BAC/CLOT/GM
- (UMLS (NCI) C0677793) =Therapeutic or Preventive Procedure
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