[A hydrazine derivative of dopa. Carbidopa is a peripheral dopa decarboxylase inhibitor that is used as an adjunct to levodopa administration to prevent peripheral biosynthesis of levodopa to dopamine, thereby reducing peripheral side effects. Carbidopa does not penetrate the blood brain barrier so that levodopa, after it reaches the brain, can be metabolized to dopamine by dopa decarboxylase where it exerts its effect on dopamine receptors. ( NCI )] (UMLS (NCI) C0006982) =Organic Chemical; Pharmacologic Substance =[CN500] ANTIPARKINSON AGENTS;;hydrazine;;3-Hydroxy-alpha-methyl-L-tyrosine;; =CARBIDOPA 25 MG;;CARBIDOPA 50 MG;;CARBIDOPA 10 MG;;Carbidopa 12.5 MG / entacapone 200 MG / Levodopa 50 MG Oral Tablet;;CARBIDOPA 37.5 MG;;
[A laboratory-made colony-stimulating factor that stimulates the production of blood cells, especially platelets, during chemotherapy. It is a cytokine that belongs to the family of drugs called hematopoietic (blood-forming) agents. Also called interleukin-2 or IL-2. ( NCI )] (UMLS (NCI) C0218986) =Amino Acid, Peptide, or Protein; Pharmacologic Substance ;; =[IM700] IMMUNE STIMULANTS;;Recombinant Protein =ALDESLEUKIN 22 MILLION UNT/VIL
[Encoded by human ALOX15 Gene, a putative mutator gene regulated by tumor-suppressor TP53, 661-amino acid 74.7 kD cytoplasmic Arachidonate 15-Lipoxygenase (Lipoxygenase Family) acts in leukotriene biosynthesis and is implicated in anti-inflammation, membrane remodeling, and cancer development or metastasis. It converts arachidonic acid to 15s-hydroperoxyeicosatetraenoic acid. (OMIM, Swiss-Prot, and NCI) ( NCI )] (UMLS (NCI) C0003692) =Amino Acid, Peptide, or Protein; Enzyme
[A radioimmunoconjugate of the humanized monoclonal antibody (MoAB) CC49 labeled with lutetium 131 (Lu-177). MoAb CC49 binds to the pancarcinoma tumor-associated glycoprotein (TAG)-72 with high affinity. Lu-177 MoAb CC49 delivers gamma radiation emitting Lu-177 nuclide directly to tumor cells that express TAG-72, thereby may be used in radioimmunotherapeutic treatment of cancers. ( NCI )] (UMLS (NCI) C0935675) Lutetium Lu 177 Monoclonal Antibody CC49;; =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Immunologic Factor
[An enzyme that catalyzes the hydrolysis of a single fatty acid ester bond in lysoglycerophosphatidates with the formation of glyceryl phosphatidates and a fatty acid. EC 3.1.1.5. ( MSH )] (UMLS (CSP) C0024361) =Amino Acid, Peptide, or Protein; Enzyme ;; =carboxylesterase;;
[A colony-stimulating factor that stimulates the production of white blood cells, especially granulocytes and macrophages, and cells (in the bone marrow) that are precursors of platelets. It is a cytokine that belongs to the family of drugs called hematopoietic (blood-forming) agents. Also called granulocyte-macrophage colony-stimulating factor (GM-CSF). ( NCI )] (UMLS (NCI) C0216231) =Amino Acid, Peptide, or Protein; Pharmacologic Substance ;; =Colony-Stimulating Factor, Granulocyte-Macrophage;;[BL400] BLOOD FORMATION PRODUCTS =sargramostim 0.5 MG/ML;;SARGRAMOSTIM 500 MCG;;SARGRAMOSTIM 250 MCG
[A synthetic peptide consisting of amino acids 27 through 35 of the melanoma differentiation antigen MART-1. 27-35(27L) MART-1 has a leucine substitution at amino acid position 27 to improve binding to HLA-A*0201. Vaccination with this agent may stimulate the host immune response to mount a cytotoxic T-lymphocyte response against melanoma cells expressing MART-1. ( NCI )] (UMLS (NCI) C1710929) 27-35(27L):MART-1 Peptide =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Immunologic Factor
[The acetate salt form of sermorelin, a synthetic, amidated 29-amino acid peptide that corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone (GHRH). Sermorelin acetate directly stimulates the pituitary gland, resulting in release of growth hormone leading to increased plasma growth hormone, which is responsible for many biological processes and counteracts growth hormone deficiency. ( NCI )] (UMLS (NCI) C0162725) =Amino Acid, Peptide, or Protein; Pharmacologic Substance ;; =GHRH;; =SERMORELIN ACETATE 50 MCG;;SERMORELIN ACETATE 1 MG;;SERMORELIN ACETATE 0.5 MG
[Human RPSA wild-type allele is located in the vicinity of 3p22.2 and is approximately 6 kb in length. This allele, which encodes 40S ribosomal protein SA, plays a role in a variety of biological processes that are mediated by interactions with cell surface receptors. ( NCI )] (UMLS (NCI) C1705231) 67LR;;LAMBR;;LAMR1;;LAMR1 Gene;;LRP;;p40;;Ribosomal Protein SA wt Allele;;RPSA wt Allele;; =Gene or Genome
[An anticancer drug that belongs to the family of drugs called enzyme inhibitors. It may inhibit the transformation of normal cells into cancer cells. ( NCI )] (UMLS (NCI) C0796327) L-778,123;;L-778123 =Organic Chemical; Pharmacologic Substance ;;
[cells from c3h mouse fibroblasts grown in tissue culture that can support replication of many types of viruses. ( CSP )] (UMLS (CSP) C0022827) =Cell ;; =cell line;;neoplastic cell
[An alcohol oxidoreductase which catalyzes the oxidation of L-iditol to L-sorbose in the presence of NAD. It also acts on D-glucitol to form D-fructose. It also acts on other closely related sugar alcohols to form the corresponding sugar. EC 1.1.1.14 ( MSH )] (UMLS (CSP) C0020809) =Amino Acid, Peptide, or Protein; Enzyme ;; =alcohol oxidoreductase;;
[An amino acid derivative used to counteract high blood pressure caused by interleukin-2. ( NCI )] (UMLS (CSP) C0069477) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;;
[L-Selectin is a cell surface glycoprotein adhesion molecule that serves as a homing receptor for lymphocytes to lymph node high endothelial venules. The molecule is composed of multiple domains: one homologous to lectins, one to epidermal growth factor, and two to C3/C4 binding protein consensus repeat units. L-Selectin may also play a role in neutrophil adhesion to endothelium at sites of inflammation. A tissue-specific mucin-like endothelial glycoprotein appears to function as ligand for L-selectin, in the role of scaffold that presents carbohydrates to the L-selectin lectin domain. PLAUR is directly associated with the carbohydrate-binding domain of L-selectin in the membrane of neutrophils, an association analogous to that between PLAUR and beta-2 integrins. (from OMIM 153240 and NCI) ( NCI )] (UMLS (CSP) C0125090) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor
[The hydrochloride salt form of methyldopa, a phenylalanine derivate and aromatic amino acid decarboxylase inhibitor with antihypertensive activity. Methyldopa is a prodrug and is metabolized in the central nervous system. The antihypertensive action of methyldopa seems to be attributable to its conversion into alpha-methylnorepinephrine, which is a potent alpha-2 adrenergic agonist that binds to and stimulates potent central inhibitory alpha-2 adrenergic receptors. This results in a decrease in sympathetic outflow and decreased blood pressure. ( NCI )] (UMLS (NCI) C0304527) =Organic Chemical; Pharmacologic Substance =METHYLDOPATE;; =METHYLDOPATE HYDROCHLORIDE 50 MG/ML
[A synthetic triarylimidazole with potential antineoplastic activity. As a Raf kinase inhibitor, L-779450 competes with ATP for binding to the Raf-1 and A-Raf catalytic sites, thus inhibiting their enzymatic activities and blocking various signal transduction pathways that depend on Raf-1 kinase (particularly the Ras-Raf-MEK-ERK cascade which is often up-regulated in neoplasms). (NCI04) ( NCI )] (UMLS (NCI) C1517681) L-779450;; =Organic Chemical; Pharmacologic Substance
[A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual, 1994, p385) The compound without isomeric designation is Deprenyl. ( MSH )] (UMLS (NCI) C0036579) =Organic Chemical; Pharmacologic Substance ;; =[CN500] ANTIPARKINSON AGENTS;;Phenethylamines =(-)-Phenylisopropylmethylpropynylamine;;
[A synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS), which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. ( NCI )] (UMLS (NCI) C0210657) =Organic Chemical; Pharmacologic Substance ;;
[The l-enantiomer of an orally-active polyphenolic aldehyde with potential antineoplastic activity. Derived primarily from unrefined cottonseed oil, l-gossypol inhibits the Bcl-2 family of proteins, resulting in induction of tumor cell apoptosis and inhibition of tumor cell proliferation. In vitro, this agent appears to be more potent than racemic gossypol or d-gossypol. ( NCI )] (UMLS (NCI) C1831823) =Organic Chemical; Pharmacologic Substance ;;