(6alpha,11beta,16alpha,17alpha)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic Acid, S-(Fluoromethyl) Ester

[The propionate salt form of fluticasone, a synthetic trifluorinated glucocorticoid receptor agonist with antiallergic, antiinflammatory and antipruritic effects. Binding and activation of the glucocorticoid receptor results in the activation of lipocortin that in turn inhibits cytosolic phospholipase A2, which triggers cascade of reactions involved in synthesis of inflammatory mediators, such as prostaglandins and leukotrienes. Secondly, mitogen-activated protein kinase (MAPK) phosphatase 1 is induced, thereby leads to dephosphorylation and inactivation of Jun N-terminal kinase directly inhibiting c-Jun mediated transcription. Finally, transcriptional activity of nuclear factor (NF)-kappa-B is blocked, thereby inhibits the transcription of cyclooxygenase 2, which is essential for prostaglandin production. ( NCI )]

UMLS (NCI) C0117996

Organic Chemical
Pharmacologic Substance

Relation/PAR: FLUTICASONE

Relation/CHD: FLUTICASONE PROPIONATE 50 MCG
FLUTICASONE PROPIONATE 500 MCG
FLUTICASONE PROPIONATE 50 MCG/ACTUAT
FLUTICASONE PROPIONATE 0.05 %
FLUTICASONE PROPIONATE 110 MCG/ACTUAT
FLUTICASONE PROPIONATE 44 MCG/ACTUAT
FLUTICASONE PROPIONATE 220 MCG/ACTUAT
FLUTICASONE PROPIONATE 250 MCG
FLUTICASONE PROPIONATE 100 MCG
FLUTICASONE PROPIONATE 0.005 %

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