1,1-Dimethylbiguanide
[A biguanide with antihyperglycemic activity. Metformin hydrochloride exerts its action by improving hepatic sensitivity to insulin, thereby suppressing hepatic glucose production and increasing hepatic glycogen stores. In addition, metformin hydrochloride increases the number and/or affinity of insulin receptors on cell surface membranes in muscle and adipose tissue, thereby increasing the sensitivity to insulin at receptor and post-receptor binding sites and increasing glucose uptake peripherally. ( NCI )]
UMLS (NCI) C0025598- Organic Chemical
- Pharmacologic Substance
Relation/PAR: Biguanides
antihyperglycemic
[HS502] HYPOGLYCEMIC AGENTS, ORAL
antihyperglycemic
[HS502] HYPOGLYCEMIC AGENTS, ORAL
Relation/CHD: 1,1-Dimethylbiguanide Hydrochloride
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