UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
B B B0 B1 B4 B7 B8 BA BB BC BD BE BF BG BH BI BK BL BM BN BO BP BR BS BT BU BV BW BX BY BZ
BE BE+ BEA BEB BEC BED BEE BEF BEG BEH BEI BEK BEL BEM BEN BEP BER BES BET BEU BEV BEX

1,2-Benzisoxazole-3-methanesulfonamide

[A sulfonamide derivative with an anticonvulsant property. The exact mechanism of action remains to be elucidated. Zonisamide appears to block sodium and calcium channels, thereby stabilizing neuronal membranes and suppressing neuronal hypersynchronization. Although zonisamide shows affinity for the gamma-aminobutyric acid (GABA) /benzodiazepine receptor ionophore complex, it does not potentiate the synaptic activity of GABA. In addition, this agent also facilitates both dopaminergic and serotonergic neurotransmission. ( NCI )]
UMLS (NCI) C0078844
 
Organic Chemical
Pharmacologic Substance
Relation/PAR: [CN400] ANTICONVULSANTS
isoxazole
Relation/CHD: ZONISAMIDE 100 MG

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