[A synthetic amino acid derivative of cyclopentanecarboxylic acid, Cycloleucine displays immunosuppressive, antineoplastic, and cytostatic properties. Believed to act in vivo as a valine antagonist and an NMDA receptor antagonist acting at the glycine site, Cycloleucine is a competitive inhibitor of many enzymes, such as methionine adenosyltransferase (S-adenosylmethionine biosynthesis). Toxicity is correlated with a block of nucleic acid methylation; cell cycle progression; and DNA, RNA and protein biosynthesis. (NCI04) ( NCI )]
UMLS (NCI) C0010575 - Amino Acid, Peptide, or Protein
- Pharmacologic Substance