15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 3-((1E)-2-((1R,3R,4S)-4-chloro-3-methoxycyclohexyl)-1-methylethenyl)-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,1
[A 33-epi-chloro-derivative of the ascomycin macrolactam with immunosuppressant property. Pimecrolimus binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineurin. Via dephosphorylation, calcineurin is the enzyme responsible for activating nuclear factor of activated T-cells (NF-AT), a T cell transcriptional regulatory factor. As a consequence, the synthesis and release of Th1- (T helper 1) and Th2- (T helper 2) type cytokines, and other inflammatory mediators from T-cells and mast cells are blocked and the expression of signals essential for the activation of inflammatory T-lymphocytes is inhibited. However, pimecrolimus mode of action is cell-selective and does not affect Langerhans' cells/dendritic cells and primary fibroblasts. ( NCI )]
UMLS (NCI) C109941433-epi-Chloro-33-desoxyascomycin
PIMECROLIMUS
PIMECROLIMUS UNIDENTIFIED
PIMECROLIMUS PREPARATION
PIMECROLIMUS UNIDENTIFIED
PIMECROLIMUS
PIMECROLIMUS UNIDENTIFIED
PIMECROLIMUS PREPARATION
PIMECROLIMUS UNIDENTIFIED
- Organic Chemical
- Pharmacologic Substance
Relation/PAR: [DE900] DERMATOLOGICALS, TOPICAL OTHER
Unclassified Ingredients
Unclassified Ingredients
Relation/CHD: PIMECROLIMUS 1 %
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