UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
K K+ K1 K2 KA KB KC KD KE KF KG KH KI KK KL KM KN KO KP KR KS KT KU KV KW KY
KDA KDH KDL KDM KDN KDO KDR KDT

150 kD Oxygen-Regulated Protein

[Highly expressed in secretory tissues (liver and pancreas) by human HYOU1 Gene (HSP70 Family), hypoxia-induced 999-aa (precursor) 150 kD Hypoxia Up-Regulated 1 Protein is an endoplasmic reticulum cytoprotectant in oxygen deprivation that may act as a chaperone with GRPs and participate in protein folding and secretion. ORP150 contains a C-terminal KNDEL sequence and N-terminal similarity to HSP70 ATPase domain. ORP150 suppression is associated with accelerated apoptosis. ORP150 expression in neurons suppresses caspase-3-like activity and enhances BDNF under hypoxia signaling. Elimination of the signal peptide through an alternative translation site may generate a cytosolic housekeeping protein. (NCI) ( NCI )]
UMLS (NCI) C0377954
 
Amino Acid, Peptide, or Protein
Biologically Active Substance

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