2,4-Oxazolidinedione, 3,5,5-trimethyl-
[A dione-type anticonvulsant with antiepileptic activity. Trimethadione reduces T-type calcium currents in thalamic neurons, thereby stabilizing neuronal membranes, raising the threshold for repetitive activities in the thalamus and inhibiting corticothalamic transmission. This decreases the abnormal thalamocortical rhythmicity, which is thought to underlie the paroxysmal three-cycle-per-second spike-and-wave pattern seen with absence (petit mal) seizures. ( NCI )]
UMLS (NCI) C0041038- Organic Chemical
- Pharmacologic Substance
Relation/PAR: [CN400] ANTICONVULSANTS
oxazole
oxazole
Relation/CHD: TRIMETHADIONE 150 MG
TRIMETHADIONE 300 MG
TRIMETHADIONE 40 MG/ML
TRIMETHADIONE 300 MG
TRIMETHADIONE 40 MG/ML
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