2-Fluoro-alpha-methyl-4-diphenylacetic Acid Sodium Salt
[The sodium salt form of flurbiprofen, a propionic acid derivative and a member of the phenylalkanoic acid group of non-steroidal antiinflammatory drugs (NSAIDs) with analgesic, antiinflammatory and antipyretic effects. Flurbiprofen non-selectively binds to and inhibits cyclooxygenase (COX). This results in a reduction of arachidonic acid conversion into prostaglandins that are involved in the regulation of pain, inflammation and fever. This NSAID also inhibits carbonic anhydrase, thereby reducing the production of hydrogen and bicarbonate ions. Upon ocular administration, flurbiprofen may reduce bicarbonate ion concentrations leading to a decrease in the production of aqueous humor, thereby lowering intraocular pressure. ( NCI )]
UMLS (NCI) C0304658- Organic Chemical
- Pharmacologic Substance
Relation/PAR: 2-Fluoro-alpha-methyl[1,1'-biphenyl]-4-acetic Acid
[OP900] OPHTHALMICS, OTHER
[OP900] OPHTHALMICS, OTHER
Relation/CHD: FLURBIPROFEN SODIUM 0.03 %
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