UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
P P- P0 P1 P2 P3 P4 P5 P6 P7 P8 P9 PA PB PC PD PE PF PG PH PI PK PL PM PN PO PP PQ PR PS PT PU PV PW PX PY
PBE PBI PBL PBM PBP PBR PBU PBX

3-(p-(bis(2-chloroethyl)amino)phenyl)-L-Alanine, Hydrochloride

[A bifunctional alkylating agent and phenylalanine derivative of nitrogen mustard. Melphalan hydrochloride is converted into highly reactive ethylenimmonium intermediates that induce covalent guanine N7-N7 intra- and inter-crosslinks and alkylation of adenine N3 of DNA. This agent also alkylates RNA and protein structures. As a result RNA transcription and protein synthesis are inhibited, ultimately leading to cell growth arrest and/or death. ( NCI )]
UMLS (NCI) C0771055
Melphalan Hydrochloride
MELPHALAN HYDROCHLORIDE PREPARATION
 
Organic Chemical
Pharmacologic Substance
Relation/PAR: 4-[bis(2-chloroethyl)amino]-L-phenylalanine
Relation/CHD: MELPHALAN HYDROCHLORIDE 50 MG

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