4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol
[A phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties. Perphenazine blocks postsynaptic dopamine 2(D2) receptors in the mesolimbic and medullary chemoreceptor trigger zone (CTZ), thereby preventing the excess of dopamine in the brain. This leads to reduction in psychotic symptoms, such as hallucinations and delusions. Perphenazine appears to exert its antiemetic activity by blocking the dopamine and histamine-1 receptor in the CTZ thereby relieving nausea and vomiting in the brain. In addition, perphenazine binds to alpha-adrenergic receptors. ( NCI )]
UMLS (NCI) C0031184- Organic Chemical
- Pharmacologic Substance
Relation/PAR: Phenothiazine
[CN701] PHENOTHIAZINES/RELATED, ANTIPSYCHOTICS
[CN701] PHENOTHIAZINES/RELATED, ANTIPSYCHOTICS
Relation/CHD: PERPHENAZINE 16 MG
PERPHENAZINE 2 MG
PERPHENAZINE 16 MG/5ML
PERPHENAZINE 8 MG
PERPHENAZINE 4 MG
PERPHENAZINE 2 MG
PERPHENAZINE 16 MG/5ML
PERPHENAZINE 8 MG
PERPHENAZINE 4 MG
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