4H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic Acid, 8-fluoro-5,6-dihydro-5-methyl-6-oxo-, Ethyl Ester
[An imidazo-benzodiazepine derivative, effective in reversing benzodiazepine-induced activities. Flumazenil antagonizes the benzodiazepine binding site of the gamma-aminobutyric acid (GABA)/benzodiazepine receptor complex in the central nervous system (CNS), thereby preventing the chloride channel opening events and inhibiting neuronal hyperpolarization. As a result, flumazenil reverses benzodiazepine-induced effects including sedation, psychomotor deficits, amnesia, and hypoventilation in a dose-dependent manner. ( NCI )]
UMLS (NCI) C0016293- Organic Chemical
- Pharmacologic Substance
Relation/PAR: Benzodiazepinones
[AD900] ANTIDOTES/DETERRENTS, OTHER
[AD900] ANTIDOTES/DETERRENTS, OTHER
Relation/CHD: FLUMAZENIL 0.1 MG/ML
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