5-(((2R,3S)-2-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)-4-morpholinyl)methyl)-1,2-dihydro-3H-1,2,4-Triazol-3-one
[A small molecule, high-affinity substance P antagonist (SPA) with antiemetic activity. Crossing the blood brain barrier, aprepitant binds selectively to the human substance P/neurokinin receptor in the central nervous system (CNS), thereby inhibiting receptor binding of endogenous substance P and substance P-induced emesis. This agent has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors. ( NCI )]
UMLS (NCI) C1176306APREPITANT
APREPITANT UNIDENTIFIED
APREPITANT PREPARATION
APREPITANT UNIDENTIFIED
APREPITANT UNIDENTIFIED
APREPITANT PREPARATION
APREPITANT UNIDENTIFIED
- Organic Chemical
- Pharmacologic Substance
Relation/PAR: [GA700] ANTIEMETICS
Unclassified Ingredients
Unclassified Ingredients
Relation/CHD: APREPITANT 125 MG
APREPITANT 80 MG
APREPITANT 125MG X1/80MG X2 CAP,PKT,3
APREPITANT 80 MG
APREPITANT 125MG X1/80MG X2 CAP,PKT,3
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