[A toluidine derivative and intermediate-acting amino amide with local anesthetic property. Prilocaine stabilizes the neuronal membrane by preferential binding to and inhibiting depolarization of the voltage-gated sodium channel. This results in a decrease in membrane permeability and subsequent inhibition of the ionic sodium influx required for the initiation and conduction of impulses. ( NCI )]
UMLS (NCI) C0033124 - Organic Chemical
- Pharmacologic Substance
Relation/PAR: Anilides
[CN204] LOCAL ANESTHETICS, INJECTION
Relation/CHD: 2-(Propylamino)-o-propionotoluidide Hydrochloride
PRILOCAINE 2.5 %