6-Chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxyacridine Dihydrochloride
[The dihydrochloride salt of quinacrine, a 9-aminoacridine derivative, with potential antineoplastic property in addition to its antiparasitic activity. Quinacrine may exert its antineoplastic activity by inhibiting the transcription and activity of both basal and inducible nuclear factor-kappaB (NF-kappaB). Continuous NF-kappaB signaling, as present in many tumors as well as during chronic inflammation, promotes the expression of anti-apoptotic proteins and cytokines while suppressing the expression of pro-apoptotic proteins, such as p53, thereby inhibiting apoptosis and inducing proliferation. The repression of NF-kappaB by quinacrine leads to an induction of the transcription of the tumor suppressor p53. The activation of p53 restores p-53-dependent apoptotic pathways and potentially leads to an inhibition of tumor cell growth. ( NCI )]
UMLS (NCI) C0949411Atabrine Dihydrochloride
Mepacrine Dihydrochloride
Quinacrine Dihydrochloride
Quinacrine Hydrochloride
SN 390
Mepacrine Dihydrochloride
Quinacrine Dihydrochloride
Quinacrine Hydrochloride
SN 390
- Organic Chemical
- Pharmacologic Substance
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