UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
K K+ K1 K2 KA KB KC KD KE KF KG KH KI KK KL KM KN KO KP KR KS KT KU KV KW KY
KDA KDH KDL KDM KDN KDO KDR KDT

95 kDa Melanocyte-Specific Secreted Glycoprotein

[Expressed in melanocytes and melanomas by human SILV Gene (PMEL17/NMB Family), 661-aa 70-kDa (precursor) Melanocyte Lineage-Specific Antigen gp100is a probable type I membrane protein containing a putative leader sequence, a potential membrane anchor segment, 5 potential N-glycosylation sites, high levels of serine and threonine, a PKD domain, and amino acid similarity to tyrosinase and CAS2 protein. PMEL17 cross reacts with antityrosinase antibodies and expression correlates with melanin content. The soluble ME20-S form is a probable proteolytic cleavage product. CD8 T lymphocytes recognize a noncontiguous spliced nonameric sequence of gp100 on melanoma cells. Splicing appears to occur by transpeptidation involving an acyl-enzyme intermediate. (NCI) ( NCI )]
UMLS (NCI) C0257766
 
Amino Acid, Peptide, or Protein
Biologically Active Substance

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