[Widely expressed by human MLLT2 Gene (AF4 Family), 1210-aa 131-kDa AF-4 Protein is a serine- and proline-rich putative transcription factor with a glutamine-rich carboxyl terminus and high sequence homology with ENL protein. A common acute leukemia chromosomal translocation t(4;11)(q21;q23) involves a fusion of MLLT2 and MLL/HRX that form reciprocal products coding for chimeric rogue proteins. ( NCI )]