A A A+ A- A0 A1 A2 A3 A4 A5 A6 A7 A8 A9 AA AB AC AD AE AF AG AH AI AJ AK AL AM AN AO AP AQ AR AS AT AU AV AW AX AY AZ
AFBP
[IGFBP1 belongs to the IGFBP family. IGFs, IGFRs, and IGFBPs regulate cell proliferation and apoptosis and the primary effect of IGFBPs appears to be modulation of IGF activity and control of IGF-mediated cell growth and metabolism. IGF-I and IGF-II circulate in plasma tightly bound to IGFBPs. Secreted IGFBPs prolong the half-life of IGFs (somatomedins) and either inhibit or stimulate the growth promoting effects of IGFs. They alter the interaction of IGFs with cell surface receptors. IGFBP1 is synthesized in liver, secretory endometrium and decidua. It binds IGF-I and IGF-II with equal affinity and phosphorylation alters its affinity for IGFs. IGFBP1 potentiates IGF-I action and its C-terminal RGD sequence may account for its ability to attach to cells and potentiate IGF-I action. IGFBP1 may act as a paracrine regulator of cell growth. (from OMIM, SWISS-PROT and NCI) ( NCI )]
UMLS (NCI) C0123256- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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