A A A+ A- A0 A1 A2 A3 A4 A5 A6 A7 A8 A9 AA AB AC AD AE AF AG AH AI AJ AK AL AM AN AO AP AQ AR AS AT AU AV AW AX AY AZ
Axil
[Encoded by human AXIN2 Gene, ubiquitous cytoplasmic Conductin may inhibit the WNT pathway by regulating beta-catenin stability. AXIN2 contains DIX, RGS-signaling, GSK-binding, beta-catenin-binding, and DSH domains. Mouse conductin organizes an APC/beta-catenin/GSK3B complex that promotes beta-catenin degradation. Conductin may facilitate phosphorylation of APC and beta-catenin by GSK3B. Armadillo repeats mediate interaction with beta-catenin. GSK3B may phosphorylate AXIN2, likely dephosphorylated by PP2A. Colorectal cancer associated with MMR gene alterations result in AXIN2 mutations, stabilization of beta-catenin, and activation of beta-catenin/TCF signaling. (from SWISS-PROT, OMIM, Proteome, and NCI) ( NCI )]
UMLS (NCI) C1332360Axin 2
AXIN2
Axis Inhibitor 2
Conductin
AXIN2
Axis Inhibitor 2
Conductin
- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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