BDNF/NT-3 Growth Factors Receptor
[Widely expressed (mainly neural tissue) by human NTRK2 Gene (IR Tyr Kinase Family) as alternative isoforms TRKB (822-aa 92-kDa precursor), TRKB-T1 (477-aa), and TRKB-T-SHC (537-aa), Neurotrophic Tyrosine Kinase Receptor Type 2 is a type I membrane receptor for BDNF, NTF3, and NTF4/5, but not NGF, involved in development and/or maintenance of the nervous system that contains 2 LRR repeats and 2 Ig-like C2-type domains. Monomeric (low affinity) and dimeric (high affinity) forms appear to exist in dynamic equilibrium. Known substrates for TRK receptors are SHC, PI-3 kinase, and PLC-gamma-1. NTRK2 undergoes ligand-mediated auto-phosphorylation. (NCI) ( NCI )]
UMLS (NCI) C0084873- Amino Acid, Peptide, or Protein
- Enzyme
- Receptor
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