[Involved in transcriptional repression, BMI1 heritably modifies chromatin, changing its expressibility. BMI1 may repress HOX genes as part of the Polycomb Complex to regulate segmental identity. BMI1 contains a ring-type, putative zinc finger and Polycomb-Group homology domain. BMI1 may complex with RING1. (from SWISS-PROT P35226, OMIM 164831, and NCI) ( NCI )]
UMLS (NCI) C0106701 - Amino Acid, Peptide, or Protein
- Biologically Active Substance