Becaplermin
[Expressed as 2 alternative isoforms in platelets by human PDGFB Gene (PDGF/VEGF Family), 241-aa 27-kDa (precursor) Platelet-Derived Growth Factor-Beta Chain is a potent mitogenic factor for mesenchymal cells characterized by a motif of eight cysteines and released by platelets upon wounding to stimulate adjacent cell growth. PDGFB can exist as either antiparallel disulfide-linked homodimers or heterodimers with Platelet-Derived Growth Factor Alpha. A-A, B-B, and A-B, dimers can bind to PDGF receptor and elicit a variety of cellular responses. A and B homodimers are implicated in transformation processes. PDGFB mutations are associated with meningioma. Reciprocal t(17;22)(q22;q13) translocations with COL1A1 result in unregulated growth factor expression and are associated with DFSP. (NCI) ( NCI )]
UMLS (NCI) C0072480- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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